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Genomic innovations linked to infection strategies across emerging pathogenic chytrid fungi

Rhys A Farrer, An Martel UGent, Elin Verbrugghe UGent, Amr Abouelleil, Richard Ducatelle UGent, Joyce E Longcore, Timothy Y James, Frank Pasmans UGent, Matthew C Fisher and Christina A Cuomo (2017) NATURE COMMUNICATIONS. 8.
abstract
To understand the evolutionary pathways that lead to emerging infections of vertebrates, here we explore the genomic innovations that allow free-living chytrid fungi to adapt to and colonize amphibian hosts. Sequencing and comparing the genomes of two pathogenic species of Batrachochytrium to those of close saprophytic relatives reveals that pathogenicity is associated with remarkable expansions of protease and cell wall gene families, while divergent infection strategies are linked to radiations of lineage-specific gene families. By comparing the host-pathogen response to infection for both pathogens, we illuminate the traits that underpin a strikingly different immune response within a shared host species. Our results show that, despite commonalities that promote infection, specific gene-family radiations contribute to distinct infection strategies. The breadth and evolutionary novelty of candidate virulence factors that we discover underscores the urgent need to halt the advance of pathogenic chytrids and prevent incipient loss of biodiversity.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PROTEIN, CHYTRIDIOMYCOSIS, ANNOTATION, ALIGNMENT, AMPHIBIANS, EFFECTORS, HOST, TOOL, IDENTIFICATION, PREDICTION
journal title
NATURE COMMUNICATIONS
Nat. Commun.
volume
8
article number
14742
pages
11 pages
Web of Science type
Article
Web of Science id
000396856000001
ISSN
2041-1723
DOI
10.1038/ncomms14742
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8518556
handle
http://hdl.handle.net/1854/LU-8518556
date created
2017-04-25 07:05:27
date last changed
2017-05-04 14:37:02
@article{8518556,
  abstract     = {To understand the evolutionary pathways that lead to emerging infections of vertebrates, here we explore the genomic innovations that allow free-living chytrid fungi to adapt to and colonize amphibian hosts. Sequencing and comparing the genomes of two pathogenic species of Batrachochytrium to those of close saprophytic relatives reveals that pathogenicity is associated with remarkable expansions of protease and cell wall gene families, while divergent infection strategies are linked to radiations of lineage-specific gene families. By comparing the host-pathogen response to infection for both pathogens, we illuminate the traits that underpin a strikingly different immune response within a shared host species. Our results show that, despite commonalities that promote infection, specific gene-family radiations contribute to distinct infection strategies. The breadth and evolutionary novelty of candidate virulence factors that we discover underscores the urgent need to halt the advance of pathogenic chytrids and prevent incipient loss of biodiversity.},
  articleno    = {14742},
  author       = {Farrer, Rhys A and Martel, An and Verbrugghe, Elin and Abouelleil, Amr and Ducatelle, Richard and Longcore, Joyce E and James, Timothy Y and Pasmans, Frank and Fisher, Matthew C and Cuomo, Christina A},
  issn         = {2041-1723},
  journal      = {NATURE COMMUNICATIONS},
  keyword      = {PROTEIN,CHYTRIDIOMYCOSIS,ANNOTATION,ALIGNMENT,AMPHIBIANS,EFFECTORS,HOST,TOOL,IDENTIFICATION,PREDICTION},
  language     = {eng},
  pages        = {11},
  title        = {Genomic innovations linked to infection strategies across emerging pathogenic chytrid fungi},
  url          = {http://dx.doi.org/10.1038/ncomms14742},
  volume       = {8},
  year         = {2017},
}

Chicago
Farrer, Rhys A, An Martel, Elin Verbrugghe, Amr Abouelleil, Richard Ducatelle, Joyce E Longcore, Timothy Y James, Frank Pasmans, Matthew C Fisher, and Christina A Cuomo. 2017. “Genomic Innovations Linked to Infection Strategies Across Emerging Pathogenic Chytrid Fungi.” Nature Communications 8.
APA
Farrer, R. A., Martel, A., Verbrugghe, E., Abouelleil, A., Ducatelle, R., Longcore, J. E., James, T. Y., et al. (2017). Genomic innovations linked to infection strategies across emerging pathogenic chytrid fungi. NATURE COMMUNICATIONS, 8.
Vancouver
1.
Farrer RA, Martel A, Verbrugghe E, Abouelleil A, Ducatelle R, Longcore JE, et al. Genomic innovations linked to infection strategies across emerging pathogenic chytrid fungi. NATURE COMMUNICATIONS. 2017;8.
MLA
Farrer, Rhys A, An Martel, Elin Verbrugghe, et al. “Genomic Innovations Linked to Infection Strategies Across Emerging Pathogenic Chytrid Fungi.” NATURE COMMUNICATIONS 8 (2017): n. pag. Print.