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Dysbiosis by neutralizing commensal mediated inhibition of pathobionts

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Abstract
Dysbiosis in the periodontal microbiota is associated with the development of periodontal diseases. Little is known about the initiation of dysbiosis. It was hypothesized that some commensal bacteria suppress the outgrowth of pathobionts by H2O2 production. However, serum and blood components released due to inflammation can neutralize this suppressive effect, leading to the initiation of dysbiosis. Agar plate, dual-species and multi-species ecology experiments showed that H2O2 production by commensal bacteria decreases pathobiont growth and colonization. Peroxidase and blood components neutralize this inhibitory effect primarily by an exogenous peroxidase activity without stimulating growth and biofilm formation of pathobionts directly. In multi-species environments, neutralization of H2O2 resulted in 2 to 3 log increases in pathobionts, a hallmark for dysbiosis. Our data show that in oral biofilms, commensal species suppress the amounts of pathobionts by H2O2 production. Inflammation can neutralize this effect and thereby initiates dysbiosis by allowing the outgrowth of pathobionts.
Keywords
GINGIVAL CREVICULAR FLUID, STREPTOCOCCUS-SANGUINIS, PORPHYROMONAS-GINGIVALIS, PREVOTELLA-INTERMEDIA, HYDROGEN-PEROXIDE, PERIODONTITIS, HEMOGLOBIN, ACTINOMYCETEMCOMITANS, COLONIZATION, ANTAGONISM

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Citation

Please use this url to cite or link to this publication:

MLA
Herrero, Esteban Rodriguez et al. “Dysbiosis by Neutralizing Commensal Mediated Inhibition of Pathobionts.” SCIENTIFIC REPORTS 6 (2016): n. pag. Print.
APA
Herrero, Esteban Rodriguez, Slomka, V., Boon, N., Bernaerts, K., Hernandez Sanabria, E., Quirynen, M., & Teughels, W. (2016). Dysbiosis by neutralizing commensal mediated inhibition of pathobionts. SCIENTIFIC REPORTS, 6.
Chicago author-date
Herrero, Esteban Rodriguez, Vera Slomka, Nico Boon, Kristel Bernaerts, Emma Hernandez Sanabria, Marc Quirynen, and Wim Teughels. 2016. “Dysbiosis by Neutralizing Commensal Mediated Inhibition of Pathobionts.” Scientific Reports 6.
Chicago author-date (all authors)
Herrero, Esteban Rodriguez, Vera Slomka, Nico Boon, Kristel Bernaerts, Emma Hernandez Sanabria, Marc Quirynen, and Wim Teughels. 2016. “Dysbiosis by Neutralizing Commensal Mediated Inhibition of Pathobionts.” Scientific Reports 6.
Vancouver
1.
Herrero ER, Slomka V, Boon N, Bernaerts K, Hernandez Sanabria E, Quirynen M, et al. Dysbiosis by neutralizing commensal mediated inhibition of pathobionts. SCIENTIFIC REPORTS. 2016;6.
IEEE
[1]
E. R. Herrero et al., “Dysbiosis by neutralizing commensal mediated inhibition of pathobionts,” SCIENTIFIC REPORTS, vol. 6, 2016.
@article{8518525,
  abstract     = {Dysbiosis in the periodontal microbiota is associated with the development of periodontal diseases. Little is known about the initiation of dysbiosis. It was hypothesized that some commensal bacteria suppress the outgrowth of pathobionts by H2O2 production. However, serum and blood components released due to inflammation can neutralize this suppressive effect, leading to the initiation of dysbiosis. Agar plate, dual-species and multi-species ecology experiments showed that H2O2 production by commensal bacteria decreases pathobiont growth and colonization. Peroxidase and blood components neutralize this inhibitory effect primarily by an exogenous peroxidase activity without stimulating growth and biofilm formation of pathobionts directly. In multi-species environments, neutralization of H2O2 resulted in 2 to 3 log increases in pathobionts, a hallmark for dysbiosis. Our data show that in oral biofilms, commensal species suppress the amounts of pathobionts by H2O2 production. Inflammation can neutralize this effect and thereby initiates dysbiosis by allowing the outgrowth of pathobionts.},
  articleno    = {38179},
  author       = {Herrero, Esteban Rodriguez and Slomka, Vera and Boon, Nico and Bernaerts, Kristel and Hernandez Sanabria, Emma and Quirynen, Marc and Teughels, Wim},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keywords     = {GINGIVAL CREVICULAR FLUID,STREPTOCOCCUS-SANGUINIS,PORPHYROMONAS-GINGIVALIS,PREVOTELLA-INTERMEDIA,HYDROGEN-PEROXIDE,PERIODONTITIS,HEMOGLOBIN,ACTINOMYCETEMCOMITANS,COLONIZATION,ANTAGONISM},
  language     = {eng},
  pages        = {10},
  title        = {Dysbiosis by neutralizing commensal mediated inhibition of pathobionts},
  url          = {http://dx.doi.org/10.1038/srep38179},
  volume       = {6},
  year         = {2016},
}

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