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An advanced in vitro technology platform to study the mechanism of action of prebiotics and probiotics in the gastrointestinal tract

Massimo Marzorati UGent and Tom Van de Wiele UGent (2016) JOURNAL OF CLINICAL GASTROENTEROLOGY. 50(suppl. 2). p.S124-S125
abstract
The gastrointestinal tract (GIT) hosts the most complex microbial community in the human body. Given the extensive metabolic potential which is present in this community, this additional organ is of key importance to maintain a healthy status and several diseases are frequently correlated with an alteration of the composition/functionality of the gut microbiota. Consequently, there is a great interest in identifying potential approaches that could modulate the microbiota and its metabolism to bring about a positive health effect. A classical approach to reach this goal is the use of prebiotics and/or probiotics. How to study the potential effect of new prebiotics/probiotics and how to localize this effect along the full GIT? Human intervention trials are the golden standard to validate functional properties of food products. Yet, most studies on gut microbiota are based on the analysis of fecal samples because they are easily collected in a non-invasive manner. A complementary option is represented by well-designed in vitro simulation technologies. Among all the available systems, the Simulator of Human Intestinal Microbial Ecosystem has already been shown to be a useful model for nutrition studies in terms of analysis of the intestinal microbial community composition and activity. The Simulator of Human Intestinal Microbial Ecosystem is a scientifically validated platform representing the physiology and microbiology of the adult human GIT. Furthermore, recent advances in in vitro modelling also allow to combine the study of bacteria-host interactions, such as mucosal adhesion and interaction with the immune system, thereby further increasing the value of the scientific output.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
gut simulation, SHIME, microbiome, mucosal, INTESTINAL MICROBIAL ECOSYSTEM, FERMENTATION PROFILE, SIMULATOR, OLIGOSACCHARIDES, LACTOBACILLI, SHIME(R)
journal title
JOURNAL OF CLINICAL GASTROENTEROLOGY
J. Clin. Gastroenterol.
volume
50
issue
suppl. 2
pages
S124 - S125
Web of Science type
Article
Web of Science id
000388538700004
JCR category
GASTROENTEROLOGY & HEPATOLOGY
JCR impact factor
3.328 (2016)
JCR rank
30/79 (2016)
JCR quartile
2 (2016)
ISSN
0192-0790
1539-2031
DOI
10.1097/MCG.0000000000000711
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8518522
handle
http://hdl.handle.net/1854/LU-8518522
date created
2017-04-24 14:07:42
date last changed
2017-09-06 13:19:24
@article{8518522,
  abstract     = {The gastrointestinal tract (GIT) hosts the most complex microbial community in the human body. Given the extensive metabolic potential which is present in this community, this additional organ is of key importance to maintain a healthy status and several diseases are frequently correlated with an alteration of the composition/functionality of the gut microbiota. Consequently, there is a great interest in identifying potential approaches that could modulate the microbiota and its metabolism to bring about a positive health effect. A classical approach to reach this goal is the use of prebiotics and/or probiotics. How to study the potential effect of new prebiotics/probiotics and how to localize this effect along the full GIT? Human intervention trials are the golden standard to validate functional properties of food products. Yet, most studies on gut microbiota are based on the analysis of fecal samples because they are easily collected in a non-invasive manner. A complementary option is represented by well-designed in vitro simulation technologies. Among all the available systems, the Simulator of Human Intestinal Microbial Ecosystem has already been shown to be a useful model for nutrition studies in terms of analysis of the intestinal microbial community composition and activity. The Simulator of Human Intestinal Microbial Ecosystem is a scientifically validated platform representing the physiology and microbiology of the adult human GIT. Furthermore, recent advances in in vitro modelling also allow to combine the study of bacteria-host interactions, such as mucosal adhesion and interaction with the immune system, thereby further increasing the value of the scientific output.},
  author       = {Marzorati, Massimo and Van de Wiele, Tom},
  issn         = {0192-0790},
  journal      = {JOURNAL OF CLINICAL GASTROENTEROLOGY},
  keyword      = {gut simulation,SHIME,microbiome,mucosal,INTESTINAL MICROBIAL ECOSYSTEM,FERMENTATION PROFILE,SIMULATOR,OLIGOSACCHARIDES,LACTOBACILLI,SHIME(R)},
  language     = {eng},
  number       = {suppl. 2},
  pages        = {S124--S125},
  title        = {An advanced in vitro technology platform to study the mechanism of action of prebiotics and probiotics in the gastrointestinal tract},
  url          = {http://dx.doi.org/10.1097/MCG.0000000000000711},
  volume       = {50},
  year         = {2016},
}

Chicago
Marzorati, Massimo, and Tom Van de Wiele. 2016. “An Advanced in Vitro Technology Platform to Study the Mechanism of Action of Prebiotics and Probiotics in the Gastrointestinal Tract.” Journal of Clinical Gastroenterology 50 (suppl. 2): S124–S125.
APA
Marzorati, M., & Van de Wiele, T. (2016). An advanced in vitro technology platform to study the mechanism of action of prebiotics and probiotics in the gastrointestinal tract. JOURNAL OF CLINICAL GASTROENTEROLOGY, 50(suppl. 2), S124–S125.
Vancouver
1.
Marzorati M, Van de Wiele T. An advanced in vitro technology platform to study the mechanism of action of prebiotics and probiotics in the gastrointestinal tract. JOURNAL OF CLINICAL GASTROENTEROLOGY. 2016;50(suppl. 2):S124–S125.
MLA
Marzorati, Massimo, and Tom Van de Wiele. “An Advanced in Vitro Technology Platform to Study the Mechanism of Action of Prebiotics and Probiotics in the Gastrointestinal Tract.” JOURNAL OF CLINICAL GASTROENTEROLOGY 50.suppl. 2 (2016): S124–S125. Print.