Advanced search
1 file | 2.00 MB Add to list

Folates in plants : research advances and progress in crop biofortification

Author
Organization
Abstract
Folates, also known as B9 vitamins, serve as donors and acceptors in one-carbon (C1) transfer reactions. The latter are involved in synthesis of many important biomolecules, such as amino acids, nucleic acids and vitamin B5. Folates also play a central role in the methyl cycle that provides one-carbon groups for methylation reactions. The important functions fulfilled by folates make them essential in all living organisms. Plants, being able to synthesize folates de novo, serve as an excellent dietary source of folates for animals that lack the respective biosynthetic pathway. Unfortunately, the most important staple crops such as rice, potato and maize are rather poor sources of folates. Insufficient folate consumption is known to cause severe developmental disorders in humans. Two approaches are employed to fight folate deficiency: pharmacological supplementation in the form of folate pills and biofortification of staple crops. As the former approach is considered rather costly for the major part of the world population, biofortification of staple crops is viewed as a decent alternative in the struggle against folate deficiency. Therefore, strategies, challenges and recent progress of folate enhancement in plants will be addressed in this review. Apart from the ever-growing need for the enhancement of nutritional quality of crops, the world population faces climate change catastrophes or environmental stresses, such as elevated temperatures, drought, salinity that severely affect growth and productivity of crops. Due to immense diversity of their biochemical functions, folates take part in virtually every aspect of plant physiology. Any disturbance to the plant folate metabolism leads to severe growth inhibition and, as a consequence, to a lower productivity. Whereas today's knowledge of folate biochemistry can be considered very profound, evidence on the physiological roles of folates in plants only starts to emerge. In the current review we will discuss the implication of folates in various aspects of plant physiology and development.
Keywords
folate, vitamin B9, biofortification, stress response, plant development, metabolism, methylation, neural tube defects, TANDEM MASS-SPECTROMETRY, ONE-CARBON METABOLISM, GTP-CYCLOHYDROLASE-I, PERFORMANCE LIQUID-CHROMATOGRAPHY, ISOTOPE DILUTION ASSAYS, REDUCTASE-THYMIDYLATE SYNTHASE, GAMMA-GLUTAMATE-SYNTHETASE, PRECURSOR P-AMINOBENZOATE, PEA LEAF MITOCHONDRIA, TRI-ENZYME EXTRACTION

Downloads

  • Folates in Plants.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 2.00 MB

Citation

Please use this url to cite or link to this publication:

MLA
Gorelova, Vera, et al. “Folates in Plants : Research Advances and Progress in Crop Biofortification.” FRONTIERS IN CHEMISTRY, vol. 5, 2017.
APA
Gorelova, V., Ambach, L., Rébeillé, F., Stove, C., & Van Der Straeten, D. (2017). Folates in plants : research advances and progress in crop biofortification. FRONTIERS IN CHEMISTRY, 5.
Chicago author-date
Gorelova, Vera, Lars Ambach, Fabrice Rébeillé, Christophe Stove, and Dominique Van Der Straeten. 2017. “Folates in Plants : Research Advances and Progress in Crop Biofortification.” FRONTIERS IN CHEMISTRY 5.
Chicago author-date (all authors)
Gorelova, Vera, Lars Ambach, Fabrice Rébeillé, Christophe Stove, and Dominique Van Der Straeten. 2017. “Folates in Plants : Research Advances and Progress in Crop Biofortification.” FRONTIERS IN CHEMISTRY 5.
Vancouver
1.
Gorelova V, Ambach L, Rébeillé F, Stove C, Van Der Straeten D. Folates in plants : research advances and progress in crop biofortification. FRONTIERS IN CHEMISTRY. 2017;5.
IEEE
[1]
V. Gorelova, L. Ambach, F. Rébeillé, C. Stove, and D. Van Der Straeten, “Folates in plants : research advances and progress in crop biofortification,” FRONTIERS IN CHEMISTRY, vol. 5, 2017.
@article{8517960,
  abstract     = {{Folates, also known as B9 vitamins, serve as donors and acceptors in one-carbon (C1) transfer reactions. The latter are involved in synthesis of many important biomolecules, such as amino acids, nucleic acids and vitamin B5. Folates also play a central role in the methyl cycle that provides one-carbon groups for methylation reactions. The important functions fulfilled by folates make them essential in all living organisms. Plants, being able to synthesize folates de novo, serve as an excellent dietary source of folates for animals that lack the respective biosynthetic pathway. Unfortunately, the most important staple crops such as rice, potato and maize are rather poor sources of folates. Insufficient folate consumption is known to cause severe developmental disorders in humans. Two approaches are employed to fight folate deficiency: pharmacological supplementation in the form of folate pills and biofortification of staple crops. As the former approach is considered rather costly for the major part of the world population, biofortification of staple crops is viewed as a decent alternative in the struggle against folate deficiency. Therefore, strategies, challenges and recent progress of folate enhancement in plants will be addressed in this review. Apart from the ever-growing need for the enhancement of nutritional quality of crops, the world population faces climate change catastrophes or environmental stresses, such as elevated temperatures, drought, salinity that severely affect growth and productivity of crops. Due to immense diversity of their biochemical functions, folates take part in virtually every aspect of plant physiology. Any disturbance to the plant folate metabolism leads to severe growth inhibition and, as a consequence, to a lower productivity. Whereas today's knowledge of folate biochemistry can be considered very profound, evidence on the physiological roles of folates in plants only starts to emerge. In the current review we will discuss the implication of folates in various aspects of plant physiology and development.}},
  articleno    = {{21}},
  author       = {{Gorelova, Vera and Ambach, Lars and Rébeillé, Fabrice and Stove, Christophe and Van Der Straeten, Dominique}},
  issn         = {{2296-2646}},
  journal      = {{FRONTIERS IN CHEMISTRY}},
  keywords     = {{folate,vitamin B9,biofortification,stress response,plant development,metabolism,methylation,neural tube defects,TANDEM MASS-SPECTROMETRY,ONE-CARBON METABOLISM,GTP-CYCLOHYDROLASE-I,PERFORMANCE LIQUID-CHROMATOGRAPHY,ISOTOPE DILUTION ASSAYS,REDUCTASE-THYMIDYLATE SYNTHASE,GAMMA-GLUTAMATE-SYNTHETASE,PRECURSOR P-AMINOBENZOATE,PEA LEAF MITOCHONDRIA,TRI-ENZYME EXTRACTION}},
  language     = {{eng}},
  pages        = {{20}},
  title        = {{Folates in plants : research advances and progress in crop biofortification}},
  url          = {{http://dx.doi.org/10.3389/fchem.2017.00021}},
  volume       = {{5}},
  year         = {{2017}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: