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Helicobacter pylori eradication in the Swedish population

Eva Doorakkers, Jesper Lagergren, Vijaya Krishna Gajulapuri, Steven Callens UGent, Lars Engstrand and Nele Brusselaers UGent (2017) SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 52(6-7). p.678-685
abstract
Objectives: Helicobacter pylori is associated with peptic ulcers and gastric cancer and its eradication aims to prevent these conditions. The recommended eradication regimen is triple therapy, consisting of a proton-pump inhibitor in combination with clarithromycin and amoxicillin or metronidazole for 7days. Yet, other antibiotic regimens are sometimes prescribed. We aimed to assess the use of eradication therapy for H. pylori in the Swedish population during the last decade. Materials and methods: This population-based study used data from the Swedish Prescribed Drug Register. From July 2005 until December 2014, all regimens that can eradicate H. pylori were identified and evaluated according to patients' age and sex and calendar year of eradication. Results: We identified 157,915 eradication episodes in 140,391 individuals (53.8% women, 42.6% older than 60years), who correspond to 1.5% of the Swedish population. The absolute number and incidence of eradications decreased over the study period. Overall, 91.0% had one eradication and 0.1% had more than three. Of all eradications, 95.4% followed the recommended regimen, while 4.7% did not. The latter group was overrepresented among individuals aged 80years (7.8%). Amoxicillin and clarithromycin were most frequently prescribed, while metronidazole was rarely used (0.01%). Other prescribed antibiotics were ciprofloxacin (2.4%), doxycycline (1.4%), nitrofurantoin (0.7%), norfloxacin (0.5%) and erythromycin (0.3%). Conclusions: During the last decade in Sweden H. pylori eradication has been frequently prescribed, but the incidence of eradication has slowly declined. Most eradications followed the recommended regimen, including those occurring after a previous eradication.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Helicobacter pylori, eradication, population-based, epidemiology, Sweden, antibiotics, TRIPLE THERAPY, QUADRUPLE THERAPY, GASTRIC-CANCER, BISMUTH, LEVOFLOXACIN, RESISTANCE, CLARITHROMYCIN, TETRACYCLINE, METAANALYSIS, AMOXICILLIN
journal title
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
Scand. J. Gastroenterol.
volume
52
issue
6-7
pages
678 - 685
Web of Science type
Article
Web of Science id
000399808100011
ISSN
0036-5521
1502-7708
DOI
10.1080/00365521.2017.1303844
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8517903
handle
http://hdl.handle.net/1854/LU-8517903
date created
2017-04-17 08:37:20
date last changed
2018-05-14 09:52:56
@article{8517903,
  abstract     = {Objectives: Helicobacter pylori is associated with peptic ulcers and gastric cancer and its eradication aims to prevent these conditions. The recommended eradication regimen is triple therapy, consisting of a proton-pump inhibitor in combination with clarithromycin and amoxicillin or metronidazole for 7days. Yet, other antibiotic regimens are sometimes prescribed. We aimed to assess the use of eradication therapy for H. pylori in the Swedish population during the last decade.
Materials and methods: This population-based study used data from the Swedish Prescribed Drug Register. From July 2005 until December 2014, all regimens that can eradicate H. pylori were identified and evaluated according to patients' age and sex and calendar year of eradication.
Results: We identified 157,915 eradication episodes in 140,391 individuals (53.8\% women, 42.6\% older than 60years), who correspond to 1.5\% of the Swedish population. The absolute number and incidence of eradications decreased over the study period. Overall, 91.0\% had one eradication and 0.1\% had more than three. Of all eradications, 95.4\% followed the recommended regimen, while 4.7\% did not. The latter group was overrepresented among individuals aged 80years (7.8\%). Amoxicillin and clarithromycin were most frequently prescribed, while metronidazole was rarely used (0.01\%). Other prescribed antibiotics were ciprofloxacin (2.4\%), doxycycline (1.4\%), nitrofurantoin (0.7\%), norfloxacin (0.5\%) and erythromycin (0.3\%).
Conclusions: During the last decade in Sweden H. pylori eradication has been frequently prescribed, but the incidence of eradication has slowly declined. Most eradications followed the recommended regimen, including those occurring after a previous eradication.},
  author       = {Doorakkers, Eva and Lagergren, Jesper and Gajulapuri, Vijaya Krishna and Callens, Steven and Engstrand, Lars and Brusselaers, Nele},
  issn         = {0036-5521},
  journal      = {SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY},
  keyword      = {Helicobacter pylori,eradication,population-based,epidemiology,Sweden,antibiotics,TRIPLE THERAPY,QUADRUPLE THERAPY,GASTRIC-CANCER,BISMUTH,LEVOFLOXACIN,RESISTANCE,CLARITHROMYCIN,TETRACYCLINE,METAANALYSIS,AMOXICILLIN},
  language     = {eng},
  number       = {6-7},
  pages        = {678--685},
  title        = {Helicobacter pylori eradication in the Swedish population},
  url          = {http://dx.doi.org/10.1080/00365521.2017.1303844},
  volume       = {52},
  year         = {2017},
}

Chicago
Doorakkers, Eva, Jesper Lagergren, Vijaya Krishna Gajulapuri, Steven Callens, Lars Engstrand, and Nele Brusselaers. 2017. “Helicobacter Pylori Eradication in the Swedish Population.” Scandinavian Journal of Gastroenterology 52 (6-7): 678–685.
APA
Doorakkers, E., Lagergren, J., Gajulapuri, V. K., Callens, S., Engstrand, L., & Brusselaers, N. (2017). Helicobacter pylori eradication in the Swedish population. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 52(6-7), 678–685.
Vancouver
1.
Doorakkers E, Lagergren J, Gajulapuri VK, Callens S, Engstrand L, Brusselaers N. Helicobacter pylori eradication in the Swedish population. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2017;52(6-7):678–85.
MLA
Doorakkers, Eva, Jesper Lagergren, Vijaya Krishna Gajulapuri, et al. “Helicobacter Pylori Eradication in the Swedish Population.” SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 52.6-7 (2017): 678–685. Print.