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Type I interferons modulate CD8⁺ T cell immunity to mRNA vaccines

Ans De Beuckelaer, Johan Grooten UGent and Stefaan De Koker (2017) TRENDS IN MOLECULAR MEDICINE. 23(3). p.216-226
abstract
mRNA vaccines have emerged as potent tools to elicit antitumor T cell immunity. They are characterized by a strong induction of type I interferons (IFNs), potent inflammatory cytokines affecting T cell differentiation and survival. Recent reports have attributed opposing roles for type I IFNs in modulating CD8(+) T cell immunity to mRNA vaccines, from profoundly stimulatory to strongly inhibitory. The mechanisms behind this duality are unclear. Disentangling the factors governing the beneficial or detrimental impact of type I IFNs on CD8(+) T cell responses is vital to the design of mRNA vaccines of increased potency. In light of recent advancements regarding the complex role of type I IFNs in regulating CD8(+) T cell immunity to infectious diseases, we posit that the dual outcome of type I IFNs on CD8(+) T cell responses to mRNA vaccination is determined by the timing and intensity of type I IFN induction relative to T cell receptor (TCR) activation.
Please use this url to cite or link to this publication:
author
organization
alternative title
Type I interferons modulate CD8(+) T cell immunity to mRNA vaccines
year
type
journalArticle (original)
publication status
published
subject
keyword
PERSISTENT LCMV INFECTION, TOLL-LIKE RECEPTORS, DENDRITIC CELLS, INTERFERON-ALPHA, STRANDED-RNA, RIG-I, EXPRESSION KINETICS, ADAPTIVE, IMMUNITY, STRUCTURAL BASIS, BACTERIAL-DNA
journal title
TRENDS IN MOLECULAR MEDICINE
Trends Mol. Med
volume
23
issue
3
pages
216 - 226
Web of Science type
Article
Web of Science id
000397143200004
ISSN
1471-4914
1471-499X
DOI
10.1016/j.molmed.2017.01.006
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8517343
handle
http://hdl.handle.net/1854/LU-8517343
date created
2017-04-07 14:12:33
date last changed
2017-08-01 08:49:14
@article{8517343,
  abstract     = {mRNA vaccines have emerged as potent tools to elicit antitumor T cell immunity. They are characterized by a strong induction of type I interferons (IFNs), potent inflammatory cytokines affecting T cell differentiation and survival. Recent reports have attributed opposing roles for type I IFNs in modulating CD8(+) T cell immunity to mRNA vaccines, from profoundly stimulatory to strongly inhibitory. The mechanisms behind this duality are unclear. Disentangling the factors governing the beneficial or detrimental impact of type I IFNs on CD8(+) T cell responses is vital to the design of mRNA vaccines of increased potency. In light of recent advancements regarding the complex role of type I IFNs in regulating CD8(+) T cell immunity to infectious diseases, we posit that the dual outcome of type I IFNs on CD8(+) T cell responses to mRNA vaccination is determined by the timing and intensity of type I IFN induction relative to T cell receptor (TCR) activation.},
  author       = {De Beuckelaer, Ans and Grooten, Johan and De Koker, Stefaan},
  issn         = {1471-4914},
  journal      = {TRENDS IN MOLECULAR MEDICINE},
  keyword      = {PERSISTENT LCMV INFECTION,TOLL-LIKE RECEPTORS,DENDRITIC CELLS,INTERFERON-ALPHA,STRANDED-RNA,RIG-I,EXPRESSION KINETICS,ADAPTIVE,IMMUNITY,STRUCTURAL BASIS,BACTERIAL-DNA},
  language     = {eng},
  number       = {3},
  pages        = {216--226},
  title        = {Type I interferons modulate CD8\unmatched{207a} T cell immunity to mRNA vaccines},
  url          = {http://dx.doi.org/10.1016/j.molmed.2017.01.006},
  volume       = {23},
  year         = {2017},
}

Chicago
De Beuckelaer, Ans, Johan Grooten, and Stefaan De Koker. 2017. “Type I Interferons Modulate CD8+ T Cell Immunity to mRNA Vaccines.” Trends in Molecular Medicine 23 (3): 216–226.
APA
De Beuckelaer, Ans, Grooten, J., & De Koker, S. (2017). Type I interferons modulate CD8+ T cell immunity to mRNA vaccines. TRENDS IN MOLECULAR MEDICINE, 23(3), 216–226.
Vancouver
1.
De Beuckelaer A, Grooten J, De Koker S. Type I interferons modulate CD8+ T cell immunity to mRNA vaccines. TRENDS IN MOLECULAR MEDICINE. 2017;23(3):216–26.
MLA
De Beuckelaer, Ans, Johan Grooten, and Stefaan De Koker. “Type I Interferons Modulate CD8+ T Cell Immunity to mRNA Vaccines.” TRENDS IN MOLECULAR MEDICINE 23.3 (2017): 216–226. Print.