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Glucocorticoid receptors : finding the middle ground

Sofie Desmet (UGent) and Karolien De Bosscher (UGent)
(2017) JOURNAL OF CLINICAL INVESTIGATION. 127(4). p.1136-1145
Author
Organization
Abstract
Glucocorticoids (GCs; referred to clinically as corticosteroids) are steroid hormones with potent anti-inflammatory and immune modulatory profiles. Depending on the context, these hormones can also mediate pro-inflammatory activities, thereby serving as primers of the immune system. Their target receptor, the GC receptor (GR), is a multi-tasking transcription factor, changing its role and function depending on cellular and organismal needs. To get a clearer idea of how to improve the safety profile of GCs, recent studies have investigated the complex mechanisms underlying GR functions. One of the key findings includes both pro-and anti-inflammatory roles of GR, and a future challenge will be to understand how such paradoxical findings can be reconciled and how GR ultimately shifts the balance to a net anti-inflammatory profile. As such, there is consensus that GR deserves a second life as a drug target, with either refined classic GCs or a novel generation of nonsteroidal GR-targeting molecules, to meet the increasing clinical needs of today to treat inflammation and cancer.
Keywords
NF-KAPPA-B, ACTIVATED PROTEIN-KINASE, TRANSCRIPTIONAL COREGULATOR GRIP1, COLLAGEN-INDUCED ARTHRITIS, CREB-BINDING-PROTEIN, INNATE IMMUNE-SYSTEM, PHOSPHATASE 1 DUSP1, TOLL-LIKE RECEPTORS, GENE-EXPRESSION, TRISTETRAPROLIN EXPRESSION

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Citation

Please use this url to cite or link to this publication:

Chicago
Desmet, Sofie, and Karolien De Bosscher. 2017. “Glucocorticoid Receptors : Finding the Middle Ground.” Journal of Clinical Investigation 127 (4): 1136–1145.
APA
Desmet, Sofie, & De Bosscher, K. (2017). Glucocorticoid receptors : finding the middle ground. JOURNAL OF CLINICAL INVESTIGATION, 127(4), 1136–1145.
Vancouver
1.
Desmet S, De Bosscher K. Glucocorticoid receptors : finding the middle ground. JOURNAL OF CLINICAL INVESTIGATION. 2017;127(4):1136–45.
MLA
Desmet, Sofie, and Karolien De Bosscher. “Glucocorticoid Receptors : Finding the Middle Ground.” JOURNAL OF CLINICAL INVESTIGATION 127.4 (2017): 1136–1145. Print.
@article{8517159,
  abstract     = {Glucocorticoids (GCs; referred to clinically as corticosteroids) are steroid hormones with potent anti-inflammatory and immune modulatory profiles. Depending on the context, these hormones can also mediate pro-inflammatory activities, thereby serving as primers of the immune system. Their target receptor, the GC receptor (GR), is a multi-tasking transcription factor, changing its role and function depending on cellular and organismal needs. To get a clearer idea of how to improve the safety profile of GCs, recent studies have investigated the complex mechanisms underlying GR functions. One of the key findings includes both pro-and anti-inflammatory roles of GR, and a future challenge will be to understand how such paradoxical findings can be reconciled and how GR ultimately shifts the balance to a net anti-inflammatory profile. As such, there is consensus that GR deserves a second life as a drug target, with either refined classic GCs or a novel generation of nonsteroidal GR-targeting molecules, to meet the increasing clinical needs of today to treat inflammation and cancer.},
  author       = {Desmet, Sofie and De Bosscher, Karolien},
  issn         = {0021-9738},
  journal      = {JOURNAL OF CLINICAL INVESTIGATION},
  language     = {eng},
  number       = {4},
  pages        = {1136--1145},
  title        = {Glucocorticoid receptors : finding the middle ground},
  url          = {http://dx.doi.org/10.1172/jci88886},
  volume       = {127},
  year         = {2017},
}

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