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Glucocorticoid receptors : finding the middle ground

Sofie Desmet UGent and Karolien De Bosscher UGent (2017) JOURNAL OF CLINICAL INVESTIGATION. 127(4). p.1136-1145
abstract
Glucocorticoids (GCs; referred to clinically as corticosteroids) are steroid hormones with potent anti-inflammatory and immune modulatory profiles. Depending on the context, these hormones can also mediate pro-inflammatory activities, thereby serving as primers of the immune system. Their target receptor, the GC receptor (GR), is a multi-tasking transcription factor, changing its role and function depending on cellular and organismal needs. To get a clearer idea of how to improve the safety profile of GCs, recent studies have investigated the complex mechanisms underlying GR functions. One of the key findings includes both pro-and anti-inflammatory roles of GR, and a future challenge will be to understand how such paradoxical findings can be reconciled and how GR ultimately shifts the balance to a net anti-inflammatory profile. As such, there is consensus that GR deserves a second life as a drug target, with either refined classic GCs or a novel generation of nonsteroidal GR-targeting molecules, to meet the increasing clinical needs of today to treat inflammation and cancer.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
NF-KAPPA-B, ACTIVATED PROTEIN-KINASE, TRANSCRIPTIONAL COREGULATOR GRIP1, COLLAGEN-INDUCED ARTHRITIS, CREB-BINDING-PROTEIN, INNATE IMMUNE-SYSTEM, PHOSPHATASE 1 DUSP1, TOLL-LIKE RECEPTORS, GENE-EXPRESSION, TRISTETRAPROLIN EXPRESSION
journal title
JOURNAL OF CLINICAL INVESTIGATION
J. Clin. Invest.
volume
127
issue
4
pages
1136 - 1145
Web of Science type
Review
Web of Science id
000398183300005
ISSN
0021-9738
1558-8238
DOI
10.1172/jci88886
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8517159
handle
http://hdl.handle.net/1854/LU-8517159
date created
2017-04-06 11:00:04
date last changed
2017-08-03 09:15:39
@article{8517159,
  abstract     = {Glucocorticoids (GCs; referred to clinically as corticosteroids) are steroid hormones with potent anti-inflammatory and immune modulatory profiles. Depending on the context, these hormones can also mediate pro-inflammatory activities, thereby serving as primers of the immune system. Their target receptor, the GC receptor (GR), is a multi-tasking transcription factor, changing its role and function depending on cellular and organismal needs. To get a clearer idea of how to improve the safety profile of GCs, recent studies have investigated the complex mechanisms underlying GR functions. One of the key findings includes both pro-and anti-inflammatory roles of GR, and a future challenge will be to understand how such paradoxical findings can be reconciled and how GR ultimately shifts the balance to a net anti-inflammatory profile. As such, there is consensus that GR deserves a second life as a drug target, with either refined classic GCs or a novel generation of nonsteroidal GR-targeting molecules, to meet the increasing clinical needs of today to treat inflammation and cancer.},
  author       = {Desmet, Sofie and De Bosscher, Karolien},
  issn         = {0021-9738},
  journal      = {JOURNAL OF CLINICAL INVESTIGATION},
  keyword      = {NF-KAPPA-B,ACTIVATED PROTEIN-KINASE,TRANSCRIPTIONAL COREGULATOR GRIP1,COLLAGEN-INDUCED ARTHRITIS,CREB-BINDING-PROTEIN,INNATE IMMUNE-SYSTEM,PHOSPHATASE 1 DUSP1,TOLL-LIKE RECEPTORS,GENE-EXPRESSION,TRISTETRAPROLIN EXPRESSION},
  language     = {eng},
  number       = {4},
  pages        = {1136--1145},
  title        = {Glucocorticoid receptors : finding the middle ground},
  url          = {http://dx.doi.org/10.1172/jci88886},
  volume       = {127},
  year         = {2017},
}

Chicago
Desmet, Sofie, and Karolien De Bosscher. 2017. “Glucocorticoid Receptors : Finding the Middle Ground.” Journal of Clinical Investigation 127 (4): 1136–1145.
APA
Desmet, Sofie, & De Bosscher, K. (2017). Glucocorticoid receptors : finding the middle ground. JOURNAL OF CLINICAL INVESTIGATION, 127(4), 1136–1145.
Vancouver
1.
Desmet S, De Bosscher K. Glucocorticoid receptors : finding the middle ground. JOURNAL OF CLINICAL INVESTIGATION. 2017;127(4):1136–45.
MLA
Desmet, Sofie, and Karolien De Bosscher. “Glucocorticoid Receptors : Finding the Middle Ground.” JOURNAL OF CLINICAL INVESTIGATION 127.4 (2017): 1136–1145. Print.