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Animal models of colorectal peritoneal metastasis

Félix Gremonprez (UGent) , Wouter Willaert (UGent) and Wim Ceelen (UGent)
(2016) PLEURA AND PERITONEUM. 1(1). p.23-43
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Abstract
Colorectal cancer remains an important cause of mortality worldwide. The presence of peritoneal carcinomatosis (PC) causes significant symptoms and is notoriously difficult to treat. Therefore, informative preclinical research into the mechanisms and possible novel treatment options of colorectal PC is essential in order to improve the prognostic outlook in these patients. Several syngeneic and xenograft animal models of colorectal PC were established, studying a wide range of experimental procedures and substances. Regrettably, more sophisticated models such as those giving rise to spontaneous PC or involving genetically engineered mice are lacking. Here, we provide an overview of all reported colorectal PC animal models and briefly discuss their use, strengths, and limitations.
Keywords
metastasis, mouse model, PDX model, peritoneal, HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY, COLON-CARCINOMA CELLS, ENDOTHELIAL GROWTH-FACTOR, LAPAROSCOPIC FLUORESCENCE DIAGNOSIS, GASTROINTESTINAL CANCER-CELLS, DISSEMINATED TUMOR-MODEL, AMINOLEVULINIC-ACID ALA, RAT MODEL, IN-VITRO, CYTOREDUCTIVE SURGERY

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Citation

Please use this url to cite or link to this publication:

Chicago
Gremonprez, Félix, Wouter Willaert, and Wim Ceelen. 2016. “Animal Models of Colorectal Peritoneal Metastasis.” Pleura and Peritoneum 1 (1): 23–43.
APA
Gremonprez, F., Willaert, W., & Ceelen, W. (2016). Animal models of colorectal peritoneal metastasis. PLEURA AND PERITONEUM, 1(1), 23–43.
Vancouver
1.
Gremonprez F, Willaert W, Ceelen W. Animal models of colorectal peritoneal metastasis. PLEURA AND PERITONEUM. 2016;1(1):23–43.
MLA
Gremonprez, Félix, Wouter Willaert, and Wim Ceelen. “Animal Models of Colorectal Peritoneal Metastasis.” PLEURA AND PERITONEUM 1.1 (2016): 23–43. Print.
@article{8517032,
  abstract     = {Colorectal cancer remains an important cause of mortality worldwide. The presence of peritoneal carcinomatosis (PC) causes significant symptoms and is notoriously difficult to treat. Therefore, informative preclinical research into the mechanisms and possible novel treatment options of colorectal PC is essential in order to improve the prognostic outlook in these patients. Several syngeneic and xenograft animal models of colorectal PC were established, studying a wide range of experimental procedures and substances. Regrettably, more sophisticated models such as those giving rise to spontaneous PC or involving genetically engineered mice are lacking. Here, we provide an overview of all reported colorectal PC animal models and briefly discuss their use, strengths, and limitations.},
  author       = {Gremonprez, Félix and Willaert, Wouter and Ceelen, Wim},
  issn         = {2364-7671},
  journal      = {PLEURA AND PERITONEUM},
  keywords     = {metastasis,mouse model,PDX model,peritoneal,HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY,COLON-CARCINOMA CELLS,ENDOTHELIAL GROWTH-FACTOR,LAPAROSCOPIC FLUORESCENCE DIAGNOSIS,GASTROINTESTINAL CANCER-CELLS,DISSEMINATED TUMOR-MODEL,AMINOLEVULINIC-ACID ALA,RAT MODEL,IN-VITRO,CYTOREDUCTIVE SURGERY},
  language     = {eng},
  number       = {1},
  pages        = {23--43},
  title        = {Animal models of colorectal peritoneal metastasis},
  url          = {http://dx.doi.org/10.1515/pap-2016-0006},
  volume       = {1},
  year         = {2016},
}

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