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Theoretical approaches to understanding root vascular patterning : a consensus between recent models

Nathan Mellor, Milad Adibi, Sedeer El-Showk, Bert De Rybel UGent, John King, Ari Pekka Mähönen, Dolf Weijers and Anthony Bishopp (2017) JOURNAL OF EXPERIMENTAL BOTANY. 68(1). p.5-16
abstract
The root vascular tissues provide an excellent system for studying organ patterning, as the specification of these tissues signals a transition from radial symmetry to bisymmetric patterns. The patterning process is controlled by the combined action of hormonal signaling/transport pathways, transcription factors, and miRNA that operate through a series of non-linear pathways to drive pattern formation collectively. With the discovery of multiple components and feedback loops controlling patterning, it has become increasingly difficult to understand how these interactions act in unison to determine pattern formation in multicellular tissues. Three independent mathematical models of root vascular patterning have been formulated in the last few years, providing an excellent example of how theoretical approaches can complement experimental studies to provide new insights into complex systems. In many aspects these models support each other; however, each study also provides its own novel findings and unique viewpoints. Here we reconcile these models by identifying the commonalities and exploring the differences between them by testing how transferable findings are between models. New simulations herein support the hypothesis that an asymmetry in auxin input can direct the formation of vascular pattern. We show that the xylem axis can act as a sole source of cytokinin and specify the correct pattern, but also that broader patterns of cytokinin production are also able to pattern the root. By comparing the three modeling approaches, we gain further insight into vascular patterning and identify several key areas for experimental investigation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
AUXIN TRANSPORT, CELL-FATE, ARABIDOPSIS-THALIANA, TRANSCRIPTION FACTOR, EFFLUX, GROWTH, ORGANOGENESIS, GRAVITROPISM, MECHANISM, ESTABLISH, Auxin, cytokinin, mathematical modeling, organ patterning, systems, biology, vascular development
journal title
JOURNAL OF EXPERIMENTAL BOTANY
J. Exp. Bot.
volume
68
issue
1
pages
5 - 16
Web of Science type
Article
Web of Science id
000397127100002
ISSN
0022-0957
1460-2431
DOI
10.1093/jxb/erw410
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8516871
handle
http://hdl.handle.net/1854/LU-8516871
date created
2017-04-04 12:35:28
date last changed
2017-06-01 08:29:45
@article{8516871,
  abstract     = {The root vascular tissues provide an excellent system for studying organ patterning, as the specification of these tissues signals a transition from radial symmetry to bisymmetric patterns. The patterning process is controlled by the combined action of hormonal signaling/transport pathways, transcription factors, and miRNA that operate through a series of non-linear pathways to drive pattern formation collectively. With the discovery of multiple components and feedback loops controlling patterning, it has become increasingly difficult to understand how these interactions act in unison to determine pattern formation in multicellular tissues. Three independent mathematical models of root vascular patterning have been formulated in the last few years, providing an excellent example of how theoretical approaches can complement experimental studies to provide new insights into complex systems. In many aspects these models support each other; however, each study also provides its own novel findings and unique viewpoints. Here we reconcile these models by identifying the commonalities and exploring the differences between them by testing how transferable findings are between models. New simulations herein support the hypothesis that an asymmetry in auxin input can direct the formation of vascular pattern. We show that the xylem axis can act as a sole source of cytokinin and specify the correct pattern, but also that broader patterns of cytokinin production are also able to pattern the root. By comparing the three modeling approaches, we gain further insight into vascular patterning and identify several key areas for experimental investigation.},
  author       = {Mellor, Nathan and Adibi, Milad and El-Showk, Sedeer and De Rybel, Bert and King, John and M{\"a}h{\"o}nen, Ari Pekka and Weijers, Dolf and Bishopp, Anthony},
  issn         = {0022-0957},
  journal      = {JOURNAL OF EXPERIMENTAL BOTANY},
  keyword      = {AUXIN TRANSPORT,CELL-FATE,ARABIDOPSIS-THALIANA,TRANSCRIPTION FACTOR,EFFLUX,GROWTH,ORGANOGENESIS,GRAVITROPISM,MECHANISM,ESTABLISH,Auxin,cytokinin,mathematical modeling,organ patterning,systems,biology,vascular development},
  language     = {eng},
  number       = {1},
  pages        = {5--16},
  title        = {Theoretical approaches to understanding root vascular patterning : a consensus between recent models},
  url          = {http://dx.doi.org/10.1093/jxb/erw410},
  volume       = {68},
  year         = {2017},
}

Chicago
Mellor, Nathan, Milad Adibi, Sedeer El-Showk, Bert De Rybel, John King, Ari Pekka Mähönen, Dolf Weijers, and Anthony Bishopp. 2017. “Theoretical Approaches to Understanding Root Vascular Patterning : a Consensus Between Recent Models.” Journal of Experimental Botany 68 (1): 5–16.
APA
Mellor, N., Adibi, M., El-Showk, S., De Rybel, B., King, J., Mähönen, A. P., Weijers, D., et al. (2017). Theoretical approaches to understanding root vascular patterning : a consensus between recent models. JOURNAL OF EXPERIMENTAL BOTANY, 68(1), 5–16.
Vancouver
1.
Mellor N, Adibi M, El-Showk S, De Rybel B, King J, Mähönen AP, et al. Theoretical approaches to understanding root vascular patterning : a consensus between recent models. JOURNAL OF EXPERIMENTAL BOTANY. 2017;68(1):5–16.
MLA
Mellor, Nathan, Milad Adibi, Sedeer El-Showk, et al. “Theoretical Approaches to Understanding Root Vascular Patterning : a Consensus Between Recent Models.” JOURNAL OF EXPERIMENTAL BOTANY 68.1 (2017): 5–16. Print.