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Canine synovial fluid biomarkers for early detection and monitoring of osteoarthritis

(2017) VETERINARY RECORD. 180(13). p.328-329
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Abstract
Secondary, non-inflammatory osteoarthritis (OA) is a common disorder in dogs. Its silent onset prevents early diagnosis and delays treatment. Synovial fluid biomarkers can detect OA at an early stage, before the presence of radiographic signs. In addition, these local biomarkers can aid prognosis of the disease, monitor the response to treatment and can be used to assess the degree of OA. Currently three groups of canine synovial fluid biomarkers have been the focus of research: proinflammatory mediators, enzymes and their inhibitors, and extracellular cartilage degeneration products. These have been investigated in the elbow, hip and stifle joints of both normal dogs and dogs with naturally occurring and experimentally induced OA. None of these biomarkers are currently used in practice for the detection of canine OA at an early stage. A positive relationship between canine synovial fluid biomarkers and OA has been demonstrated, yet no molecular diagnostic test has been developed so far.
Keywords
CRANIAL CRUCIATE LIGAMENT, RESISTANT ACID-PHOSPHATASE, OLIGOMERIC MATRIX PROTEIN, MESSENGER-RNA EXPRESSION, TUMOR-NECROSIS-FACTOR, C-REACTIVE PROTEIN, ARTICULAR-CARTILAGE, STIFLE JOINTS, CHONDROITIN SULFATE, TISSUE INHIBITOR

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Chicago
de Bakker, Evelien, Veerle Stroobants, Femke Vandael, Bernadette Van Ryssen, and Evelyne Meyer. 2017. “Canine Synovial Fluid Biomarkers for Early Detection and Monitoring of Osteoarthritis.” Veterinary Record 180 (13): 328–329.
APA
de Bakker, E., Stroobants, V., Vandael, F., Van Ryssen, B., & Meyer, E. (2017). Canine synovial fluid biomarkers for early detection and monitoring of osteoarthritis. VETERINARY RECORD, 180(13), 328–329.
Vancouver
1.
de Bakker E, Stroobants V, Vandael F, Van Ryssen B, Meyer E. Canine synovial fluid biomarkers for early detection and monitoring of osteoarthritis. VETERINARY RECORD. 2017;180(13):328–9.
MLA
de Bakker, Evelien, Veerle Stroobants, Femke Vandael, et al. “Canine Synovial Fluid Biomarkers for Early Detection and Monitoring of Osteoarthritis.” VETERINARY RECORD 180.13 (2017): 328–329. Print.
@article{8516778,
  abstract     = {Secondary, non-inflammatory osteoarthritis (OA) is a common disorder in dogs. Its silent onset prevents early diagnosis and delays treatment. Synovial fluid biomarkers can detect OA at an early stage, before the presence of radiographic signs. In addition, these local biomarkers can aid prognosis of the disease, monitor the response to treatment and can be used to assess the degree of OA. Currently three groups of canine synovial fluid biomarkers have been the focus of research: proinflammatory mediators, enzymes and their inhibitors, and extracellular cartilage degeneration products. These have been investigated in the elbow, hip and stifle joints of both normal dogs and dogs with naturally occurring and experimentally induced OA. None of these biomarkers are currently used in practice for the detection of canine OA at an early stage. A positive relationship between canine synovial fluid biomarkers and OA has been demonstrated, yet no molecular diagnostic test has been developed so far.},
  author       = {de Bakker, Evelien and Stroobants, Veerle and Vandael, Femke and Van Ryssen, Bernadette and Meyer, Evelyne},
  issn         = {0042-4900},
  journal      = {VETERINARY RECORD},
  keyword      = {CRANIAL CRUCIATE LIGAMENT,RESISTANT ACID-PHOSPHATASE,OLIGOMERIC MATRIX PROTEIN,MESSENGER-RNA EXPRESSION,TUMOR-NECROSIS-FACTOR,C-REACTIVE PROTEIN,ARTICULAR-CARTILAGE,STIFLE JOINTS,CHONDROITIN SULFATE,TISSUE INHIBITOR},
  language     = {eng},
  number       = {13},
  pages        = {328--329},
  title        = {Canine synovial fluid biomarkers for early detection and monitoring of osteoarthritis},
  url          = {http://dx.doi.org/10.1136/vr.103982},
  volume       = {180},
  year         = {2017},
}

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