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Canine synovial fluid biomarkers for early detection and monitoring of osteoarthritis

Evelien de Bakker UGent, Veerle Stroobants UGent, Femke Vandael UGent, Bernadette Van Ryssen UGent and Evelyne Meyer UGent (2017) VETERINARY RECORD. 180(13). p.328-329
abstract
Secondary, non-inflammatory osteoarthritis (OA) is a common disorder in dogs. Its silent onset prevents early diagnosis and delays treatment. Synovial fluid biomarkers can detect OA at an early stage, before the presence of radiographic signs. In addition, these local biomarkers can aid prognosis of the disease, monitor the response to treatment and can be used to assess the degree of OA. Currently three groups of canine synovial fluid biomarkers have been the focus of research: proinflammatory mediators, enzymes and their inhibitors, and extracellular cartilage degeneration products. These have been investigated in the elbow, hip and stifle joints of both normal dogs and dogs with naturally occurring and experimentally induced OA. None of these biomarkers are currently used in practice for the detection of canine OA at an early stage. A positive relationship between canine synovial fluid biomarkers and OA has been demonstrated, yet no molecular diagnostic test has been developed so far.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
CRANIAL CRUCIATE LIGAMENT, RESISTANT ACID-PHOSPHATASE, OLIGOMERIC MATRIX PROTEIN, MESSENGER-RNA EXPRESSION, TUMOR-NECROSIS-FACTOR, C-REACTIVE PROTEIN, ARTICULAR-CARTILAGE, STIFLE JOINTS, CHONDROITIN SULFATE, TISSUE INHIBITOR
journal title
VETERINARY RECORD
Vet. Rec.
volume
180
issue
13
pages
328 - 329
Web of Science type
Review
Web of Science id
000399379300016
ISSN
0042-4900
2042-7670
DOI
10.1136/vr.103982
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8516778
handle
http://hdl.handle.net/1854/LU-8516778
date created
2017-04-03 15:22:43
date last changed
2017-05-22 12:45:20
@article{8516778,
  abstract     = {Secondary, non-inflammatory osteoarthritis (OA) is a common disorder in dogs. Its silent onset prevents early diagnosis and delays treatment. Synovial fluid biomarkers can detect OA at an early stage, before the presence of radiographic signs. In addition, these local biomarkers can aid prognosis of the disease, monitor the response to treatment and can be used to assess the degree of OA. Currently three groups of canine synovial fluid biomarkers have been the focus of research: proinflammatory mediators, enzymes and their inhibitors, and extracellular cartilage degeneration products. These have been investigated in the elbow, hip and stifle joints of both normal dogs and dogs with naturally occurring and experimentally induced OA. None of these biomarkers are currently used in practice for the detection of canine OA at an early stage. A positive relationship between canine synovial fluid biomarkers and OA has been demonstrated, yet no molecular diagnostic test has been developed so far.},
  author       = {de Bakker, Evelien and Stroobants, Veerle and Vandael, Femke and Van Ryssen, Bernadette and Meyer, Evelyne},
  issn         = {0042-4900},
  journal      = {VETERINARY RECORD},
  keyword      = {CRANIAL CRUCIATE LIGAMENT,RESISTANT ACID-PHOSPHATASE,OLIGOMERIC MATRIX PROTEIN,MESSENGER-RNA EXPRESSION,TUMOR-NECROSIS-FACTOR,C-REACTIVE PROTEIN,ARTICULAR-CARTILAGE,STIFLE JOINTS,CHONDROITIN SULFATE,TISSUE INHIBITOR},
  language     = {eng},
  number       = {13},
  pages        = {328--329},
  title        = {Canine synovial fluid biomarkers for early detection and monitoring of osteoarthritis},
  url          = {http://dx.doi.org/10.1136/vr.103982},
  volume       = {180},
  year         = {2017},
}

Chicago
de Bakker, Evelien, Veerle Stroobants, Femke Vandael, Bernadette Van Ryssen, and Evelyne Meyer. 2017. “Canine Synovial Fluid Biomarkers for Early Detection and Monitoring of Osteoarthritis.” Veterinary Record 180 (13): 328–329.
APA
de Bakker, E., Stroobants, V., Vandael, F., Van Ryssen, B., & Meyer, E. (2017). Canine synovial fluid biomarkers for early detection and monitoring of osteoarthritis. VETERINARY RECORD, 180(13), 328–329.
Vancouver
1.
de Bakker E, Stroobants V, Vandael F, Van Ryssen B, Meyer E. Canine synovial fluid biomarkers for early detection and monitoring of osteoarthritis. VETERINARY RECORD. 2017;180(13):328–9.
MLA
de Bakker, Evelien, Veerle Stroobants, Femke Vandael, et al. “Canine Synovial Fluid Biomarkers for Early Detection and Monitoring of Osteoarthritis.” VETERINARY RECORD 180.13 (2017): 328–329. Print.