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Ruthenium(II) bipyridine complexes : from synthesis and crystal structures to electrochemical and cytotoxicity investigation

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Abstract
Complexes 1-4, [Ru(L)(bpy)(2)]PF6, where bpy=2,2-bipyridine; HL=3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic acid (HL2), 5-bromopyridine-2-carboxylic acid (HL3) and 6-bromopyridine-2-carboxylic acid (HL4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72h of drug action revealed that 2-4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 +/- 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200M. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthionine-sulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV-vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex-DNA interaction. [GRAPHICS]
Keywords
Ruthenium(II) bipyridine complexes, crystal structure, redox properties, cytotoxicity, DNA intercalation, FUNCTIONALIZED ETHYLENEDIAMINE-N, N'-DIACETATE-TYPE LIGANDS, RU(II) POLYPYRIDYL COMPLEXES, VITRO ANTICANCER ACTIVITY, PICOLINIC-ACID, NICKEL(II) COMPLEXES, CELLULAR UPTAKE, CANCER-CELLS, PLATINUM, AGENTS, DNA

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MLA
Baroud, Afya A et al. “Ruthenium(II) Bipyridine Complexes : from Synthesis and Crystal Structures to Electrochemical and Cytotoxicity Investigation.” JOURNAL OF COORDINATION CHEMISTRY 70.5 (2017): 831–847. Print.
APA
Baroud, A. A., Mihajlović-Lalić, L. E., Gligorijević, N., Aranđelović, S., Stanković, D., Radulović, S., Van Hecke, K., et al. (2017). Ruthenium(II) bipyridine complexes : from synthesis and crystal structures to electrochemical and cytotoxicity investigation. JOURNAL OF COORDINATION CHEMISTRY, 70(5), 831–847.
Chicago author-date
Baroud, Afya A, Ljiljana E Mihajlović-Lalić, Nevenka Gligorijević, Sandra Aranđelović, Dalibor Stanković, Siniša Radulović, Kristof Van Hecke, Aleksandar Savić, and Sanja Grgurić-Šipka. 2017. “Ruthenium(II) Bipyridine Complexes : from Synthesis and Crystal Structures to Electrochemical and Cytotoxicity Investigation.” Journal of Coordination Chemistry 70 (5): 831–847.
Chicago author-date (all authors)
Baroud, Afya A, Ljiljana E Mihajlović-Lalić, Nevenka Gligorijević, Sandra Aranđelović, Dalibor Stanković, Siniša Radulović, Kristof Van Hecke, Aleksandar Savić, and Sanja Grgurić-Šipka. 2017. “Ruthenium(II) Bipyridine Complexes : from Synthesis and Crystal Structures to Electrochemical and Cytotoxicity Investigation.” Journal of Coordination Chemistry 70 (5): 831–847.
Vancouver
1.
Baroud AA, Mihajlović-Lalić LE, Gligorijević N, Aranđelović S, Stanković D, Radulović S, et al. Ruthenium(II) bipyridine complexes : from synthesis and crystal structures to electrochemical and cytotoxicity investigation. JOURNAL OF COORDINATION CHEMISTRY. 2017;70(5):831–47.
IEEE
[1]
A. A. Baroud et al., “Ruthenium(II) bipyridine complexes : from synthesis and crystal structures to electrochemical and cytotoxicity investigation,” JOURNAL OF COORDINATION CHEMISTRY, vol. 70, no. 5, pp. 831–847, 2017.
@article{8516752,
  abstract     = {Complexes 1-4, [Ru(L)(bpy)(2)]PF6, where bpy=2,2-bipyridine; HL=3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic acid (HL2), 5-bromopyridine-2-carboxylic acid (HL3) and 6-bromopyridine-2-carboxylic acid (HL4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72h of drug action revealed that 2-4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 +/- 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200M. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthionine-sulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV-vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex-DNA interaction. [GRAPHICS]},
  author       = {Baroud, Afya A and Mihajlović-Lalić, Ljiljana E and Gligorijević, Nevenka and Aranđelović, Sandra and Stanković, Dalibor and Radulović, Siniša and Van Hecke, Kristof and Savić, Aleksandar and Grgurić-Šipka, Sanja},
  issn         = {0095-8972},
  journal      = {JOURNAL OF COORDINATION CHEMISTRY},
  keywords     = {Ruthenium(II) bipyridine complexes,crystal structure,redox properties,cytotoxicity,DNA intercalation,FUNCTIONALIZED ETHYLENEDIAMINE-N,N'-DIACETATE-TYPE LIGANDS,RU(II) POLYPYRIDYL COMPLEXES,VITRO ANTICANCER ACTIVITY,PICOLINIC-ACID,NICKEL(II) COMPLEXES,CELLULAR UPTAKE,CANCER-CELLS,PLATINUM,AGENTS,DNA},
  language     = {eng},
  number       = {5},
  pages        = {831--847},
  title        = {Ruthenium(II) bipyridine complexes : from synthesis and crystal structures to electrochemical and cytotoxicity investigation},
  url          = {http://dx.doi.org/10.1080/00958972.2017.1282611},
  volume       = {70},
  year         = {2017},
}

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