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Right ventricular function during acute exacerbation of severe equine asthma

Annelies Decloedt UGent, H Borowicz, M Slowikowska, Koen Chiers UGent, Gunther van Loon UGent and A Niedzwiedz (2017) EQUINE VETERINARY JOURNAL. 49(5). p.603-608
abstract
Background: Pulmonary hypertension has been described in horses with severe equine asthma, but its effect on the right ventricle has not been fully elucidated. Objectives: To evaluate right ventricular structure and function after a 1-week period of pulmonary hypertension secondary to acute exacerbation of severe equine asthma. Study design: Prospective study. Methods: A clinical episode of severe equine asthma was induced experimentally in six susceptible horses. Examinations in remission and on day 7 of the clinical episode included a physical examination with clinical scoring, echocardiography, arterial blood gas measurements, venous blood sampling for cardiac biomarkers, intracardiac pressure measurements, right ventricular and right atrial myocardial biopsies, airway endoscopy and bronchoalveolar lavage. After 1 month of recovery, physical examination, echocardiography and cardiac biomarker analysis were repeated. Echocardiographic and pressure measurements were compared with those in 10 healthy control horses. Results: All horses developed clinical signs of acute pulmonary obstruction. Right heart pressures increased significantly. Altered right ventricular function could be detected by tissue Doppler and speckle tracking echocardiography. Cardiac troponin concentrations did not increase significantly, but were highly elevated in one horse which exercised in the paddock prior to sampling. Focal neutrophil infiltration was present in two myocardial samples. Even in remission, asthmatic horses showed a thicker right ventricular wall, an increased left ventricular end-systolic eccentricity index at chordal level and decreased right ventricular longitudinal strain compared with controls. Main limitations: The induced clinical episode was rather mild and the number of horses was limited because of the invasive nature of the study. Conclusions: Pulmonary obstruction in asthmatic horses induces pulmonary hypertension with right ventricular structural and functional changes.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
horse, pulmonary hypertension, echocardiography, myocardial biopsy, cardiology, RECURRENT AIRWAY-OBSTRUCTION, PULMONARY-HYPERTENSION, COR-PULMONALE, HORSES, DISEASE, DYSFUNCTION, DAMAGE, RAO
journal title
EQUINE VETERINARY JOURNAL
Equine Vet. J.
editor
Celia Marr
volume
49
issue
5
pages
603 - 608
Web of Science type
Article
Web of Science id
000407637500008
ISSN
0425-1644
DOI
10.1111/evj.12675
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8515905
handle
http://hdl.handle.net/1854/LU-8515905
date created
2017-03-27 14:46:00
date last changed
2018-01-04 14:16:36
@article{8515905,
  abstract     = {Background: Pulmonary hypertension has been described in horses with severe equine asthma, but its effect on the right ventricle has not been fully elucidated. 
Objectives: To evaluate right ventricular structure and function after a 1-week period of pulmonary hypertension secondary to acute exacerbation of severe equine asthma. 
Study design: Prospective study. 
Methods: A clinical episode of severe equine asthma was induced experimentally in six susceptible horses. Examinations in remission and on day 7 of the clinical episode included a physical examination with clinical scoring, echocardiography, arterial blood gas measurements, venous blood sampling for cardiac biomarkers, intracardiac pressure measurements, right ventricular and right atrial myocardial biopsies, airway endoscopy and bronchoalveolar lavage. After 1 month of recovery, physical examination, echocardiography and cardiac biomarker analysis were repeated. Echocardiographic and pressure measurements were compared with those in 10 healthy control horses. 
Results: All horses developed clinical signs of acute pulmonary obstruction. Right heart pressures increased significantly. Altered right ventricular function could be detected by tissue Doppler and speckle tracking echocardiography. Cardiac troponin concentrations did not increase significantly, but were highly elevated in one horse which exercised in the paddock prior to sampling. Focal neutrophil infiltration was present in two myocardial samples. Even in remission, asthmatic horses showed a thicker right ventricular wall, an increased left ventricular end-systolic eccentricity index at chordal level and decreased right ventricular longitudinal strain compared with controls. 
Main limitations: The induced clinical episode was rather mild and the number of horses was limited because of the invasive nature of the study. 
Conclusions: Pulmonary obstruction in asthmatic horses induces pulmonary hypertension with right ventricular structural and functional changes.},
  author       = {Decloedt, Annelies and Borowicz, H and Slowikowska, M and Chiers, Koen and van Loon, Gunther and Niedzwiedz, A},
  editor       = {Marr, Celia},
  issn         = {0425-1644},
  journal      = {EQUINE VETERINARY JOURNAL},
  keyword      = {horse,pulmonary hypertension,echocardiography,myocardial biopsy,cardiology,RECURRENT AIRWAY-OBSTRUCTION,PULMONARY-HYPERTENSION,COR-PULMONALE,HORSES,DISEASE,DYSFUNCTION,DAMAGE,RAO},
  language     = {eng},
  number       = {5},
  pages        = {603--608},
  title        = {Right ventricular function during acute exacerbation of severe equine asthma},
  url          = {http://dx.doi.org/10.1111/evj.12675},
  volume       = {49},
  year         = {2017},
}

Chicago
Decloedt, Annelies, H Borowicz, M Slowikowska, Koen Chiers, Gunther van Loon, and A Niedzwiedz. 2017. “Right Ventricular Function During Acute Exacerbation of Severe Equine Asthma.” Ed. Celia Marr. Equine Veterinary Journal 49 (5): 603–608.
APA
Decloedt, Annelies, Borowicz, H., Slowikowska, M., Chiers, K., van Loon, G., & Niedzwiedz, A. (2017). Right ventricular function during acute exacerbation of severe equine asthma. (C. Marr, Ed.)EQUINE VETERINARY JOURNAL, 49(5), 603–608.
Vancouver
1.
Decloedt A, Borowicz H, Slowikowska M, Chiers K, van Loon G, Niedzwiedz A. Right ventricular function during acute exacerbation of severe equine asthma. Marr C, editor. EQUINE VETERINARY JOURNAL. 2017;49(5):603–8.
MLA
Decloedt, Annelies, H Borowicz, M Slowikowska, et al. “Right Ventricular Function During Acute Exacerbation of Severe Equine Asthma.” Ed. Celia Marr. EQUINE VETERINARY JOURNAL 49.5 (2017): 603–608. Print.