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Near-infrared bulk optical properties of goat wound tissue and human serum : consequences for an implantable optical glucose sensor

(2016) JOURNAL OF BIOPHOTONICS. 9(10). p.1033-1043
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Abstract
Near-infrared (NIR) spectroscopy offers a promising technological platform for continuous glucose monitoring in the human body. Moreover, these measurements could be performed in vivo with an implantable single-chip based optical sensor. However, a thin tissue layer may grow in the optical path of the sensor. As most biological tissues are highly scattering, they only allow a small fraction of the collimated light to pass, significantly reducing the light throughput. To quantify the effect of a thin tissue layer in the optical path, the bulk optical properties of serum and tissue samples grown on implanted dummy sensors were characterized using double integrating sphere and unscattered transmittance measurements. The estimated bulk optical properties were then used to calculate the light attenuation through a thin tissue layer. The combination band of glucose was found to be the better option, relative to the first overtone band, as the absorptivity of glucose molecules is higher, while the reduction in unscattered transmittance due to tissue growth is less. Additionally, as the wound tissue was found to be highly scattering, the unscattered transmittance of the tissue layer is expected to be very low. Therefore, a sensor configuration which measures the diffuse transmittance and/or reflectance instead was recommended.
Keywords
RESOLVED DIFFUSE-REFLECTANCE, DOUBLE INTEGRATING SPHERES, TURBID MEDIA, MULTIVARIATE CALIBRATION, SPECTROSCOPY, LIGHT, TRANSMISSION, COEFFICIENTS, PROPAGATION, THERAPY, Biological tissues, optical characterization, glucose, double, integrating spheres measurement, inverse adding-doubling

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Chicago
Aernouts, Ben, Sandeep Sharma, Karolien Gellynck, Lieven Vlaminck, Maria Cornelissen, and Wouter Saeys. 2016. “Near-infrared Bulk Optical Properties of Goat Wound Tissue and Human Serum : Consequences for an Implantable Optical Glucose Sensor.” Journal of Biophotonics 9 (10): 1033–1043.
APA
Aernouts, B., Sharma, S., Gellynck, K., Vlaminck, L., Cornelissen, M., & Saeys, W. (2016). Near-infrared bulk optical properties of goat wound tissue and human serum : consequences for an implantable optical glucose sensor. JOURNAL OF BIOPHOTONICS, 9(10), 1033–1043.
Vancouver
1.
Aernouts B, Sharma S, Gellynck K, Vlaminck L, Cornelissen M, Saeys W. Near-infrared bulk optical properties of goat wound tissue and human serum : consequences for an implantable optical glucose sensor. JOURNAL OF BIOPHOTONICS. 2016;9(10):1033–43.
MLA
Aernouts, Ben, Sandeep Sharma, Karolien Gellynck, et al. “Near-infrared Bulk Optical Properties of Goat Wound Tissue and Human Serum : Consequences for an Implantable Optical Glucose Sensor.” JOURNAL OF BIOPHOTONICS 9.10 (2016): 1033–1043. Print.
@article{8514909,
  abstract     = {Near-infrared (NIR) spectroscopy offers a promising technological platform for continuous glucose monitoring in the human body. Moreover, these measurements could be performed in vivo with an implantable single-chip based optical sensor. However, a thin tissue layer may grow in the optical path of the sensor. As most biological tissues are highly scattering, they only allow a small fraction of the collimated light to pass, significantly reducing the light throughput. To quantify the effect of a thin tissue layer in the optical path, the bulk optical properties of serum and tissue samples grown on implanted dummy sensors were characterized using double integrating sphere and unscattered transmittance measurements. The estimated bulk optical properties were then used to calculate the light attenuation through a thin tissue layer. The combination band of glucose was found to be the better option, relative to the first overtone band, as the absorptivity of glucose molecules is higher, while the reduction in unscattered transmittance due to tissue growth is less. Additionally, as the wound tissue was found to be highly scattering, the unscattered transmittance of the tissue layer is expected to be very low. Therefore, a sensor configuration which measures the diffuse transmittance and/or reflectance instead was recommended. },
  author       = {Aernouts, Ben and Sharma, Sandeep and Gellynck, Karolien and Vlaminck, Lieven and Cornelissen, Maria and Saeys, Wouter},
  issn         = {1864-063X},
  journal      = {JOURNAL OF BIOPHOTONICS},
  keyword      = {RESOLVED DIFFUSE-REFLECTANCE,DOUBLE INTEGRATING SPHERES,TURBID MEDIA,MULTIVARIATE CALIBRATION,SPECTROSCOPY,LIGHT,TRANSMISSION,COEFFICIENTS,PROPAGATION,THERAPY,Biological tissues,optical characterization,glucose,double,integrating spheres measurement,inverse adding-doubling},
  language     = {eng},
  number       = {10},
  pages        = {1033--1043},
  title        = {Near-infrared bulk optical properties of goat wound tissue and human serum : consequences for an implantable optical glucose sensor},
  url          = {http://dx.doi.org/10.1002/jbio.201500262},
  volume       = {9},
  year         = {2016},
}

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