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Near-infrared bulk optical properties of goat wound tissue and human serum : consequences for an implantable optical glucose sensor

Ben Aernouts, Sandeep Sharma, Karolien Gellynck UGent, Lieven Vlaminck UGent, Maria Cornelissen UGent and Wouter Saeys (2016) JOURNAL OF BIOPHOTONICS. 9(10). p.1033-1043
abstract
Near-infrared (NIR) spectroscopy offers a promising technological platform for continuous glucose monitoring in the human body. Moreover, these measurements could be performed in vivo with an implantable single-chip based optical sensor. However, a thin tissue layer may grow in the optical path of the sensor. As most biological tissues are highly scattering, they only allow a small fraction of the collimated light to pass, significantly reducing the light throughput. To quantify the effect of a thin tissue layer in the optical path, the bulk optical properties of serum and tissue samples grown on implanted dummy sensors were characterized using double integrating sphere and unscattered transmittance measurements. The estimated bulk optical properties were then used to calculate the light attenuation through a thin tissue layer. The combination band of glucose was found to be the better option, relative to the first overtone band, as the absorptivity of glucose molecules is higher, while the reduction in unscattered transmittance due to tissue growth is less. Additionally, as the wound tissue was found to be highly scattering, the unscattered transmittance of the tissue layer is expected to be very low. Therefore, a sensor configuration which measures the diffuse transmittance and/or reflectance instead was recommended.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
RESOLVED DIFFUSE-REFLECTANCE, DOUBLE INTEGRATING SPHERES, TURBID MEDIA, MULTIVARIATE CALIBRATION, SPECTROSCOPY, LIGHT, TRANSMISSION, COEFFICIENTS, PROPAGATION, THERAPY, Biological tissues, optical characterization, glucose, double, integrating spheres measurement, inverse adding-doubling
journal title
JOURNAL OF BIOPHOTONICS
J. Biophotonics
volume
9
issue
10
pages
1033 - 1043
Web of Science type
Article
Web of Science id
000388372800006
JCR category
OPTICS
JCR impact factor
4.328 (2016)
JCR rank
10/92 (2016)
JCR quartile
1 (2016)
ISSN
1864-063X
1864-0648
DOI
10.1002/jbio.201500262
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8514909
handle
http://hdl.handle.net/1854/LU-8514909
date created
2017-03-20 15:03:32
date last changed
2017-06-02 07:44:39
@article{8514909,
  abstract     = {Near-infrared (NIR) spectroscopy offers a promising technological platform for continuous glucose monitoring in the human body. Moreover, these measurements could be performed in vivo with an implantable single-chip based optical sensor. However, a thin tissue layer may grow in the optical path of the sensor. As most biological tissues are highly scattering, they only allow a small fraction of the collimated light to pass, significantly reducing the light throughput. To quantify the effect of a thin tissue layer in the optical path, the bulk optical properties of serum and tissue samples grown on implanted dummy sensors were characterized using double integrating sphere and unscattered transmittance measurements. The estimated bulk optical properties were then used to calculate the light attenuation through a thin tissue layer. The combination band of glucose was found to be the better option, relative to the first overtone band, as the absorptivity of glucose molecules is higher, while the reduction in unscattered transmittance due to tissue growth is less. Additionally, as the wound tissue was found to be highly scattering, the unscattered transmittance of the tissue layer is expected to be very low. Therefore, a sensor configuration which measures the diffuse transmittance and/or reflectance instead was recommended. },
  author       = {Aernouts, Ben and Sharma, Sandeep and Gellynck, Karolien and Vlaminck, Lieven and Cornelissen, Maria and Saeys, Wouter},
  issn         = {1864-063X},
  journal      = {JOURNAL OF BIOPHOTONICS},
  keyword      = {RESOLVED DIFFUSE-REFLECTANCE,DOUBLE INTEGRATING SPHERES,TURBID MEDIA,MULTIVARIATE CALIBRATION,SPECTROSCOPY,LIGHT,TRANSMISSION,COEFFICIENTS,PROPAGATION,THERAPY,Biological tissues,optical characterization,glucose,double,integrating spheres measurement,inverse adding-doubling},
  language     = {eng},
  number       = {10},
  pages        = {1033--1043},
  title        = {Near-infrared bulk optical properties of goat wound tissue and human serum : consequences for an implantable optical glucose sensor},
  url          = {http://dx.doi.org/10.1002/jbio.201500262},
  volume       = {9},
  year         = {2016},
}

Chicago
Aernouts, Ben, Sandeep Sharma, Karolien Gellynck, Lieven Vlaminck, Maria Cornelissen, and Wouter Saeys. 2016. “Near-infrared Bulk Optical Properties of Goat Wound Tissue and Human Serum : Consequences for an Implantable Optical Glucose Sensor.” Journal of Biophotonics 9 (10): 1033–1043.
APA
Aernouts, B., Sharma, S., Gellynck, K., Vlaminck, L., Cornelissen, M., & Saeys, W. (2016). Near-infrared bulk optical properties of goat wound tissue and human serum : consequences for an implantable optical glucose sensor. JOURNAL OF BIOPHOTONICS, 9(10), 1033–1043.
Vancouver
1.
Aernouts B, Sharma S, Gellynck K, Vlaminck L, Cornelissen M, Saeys W. Near-infrared bulk optical properties of goat wound tissue and human serum : consequences for an implantable optical glucose sensor. JOURNAL OF BIOPHOTONICS. 2016;9(10):1033–43.
MLA
Aernouts, Ben, Sandeep Sharma, Karolien Gellynck, et al. “Near-infrared Bulk Optical Properties of Goat Wound Tissue and Human Serum : Consequences for an Implantable Optical Glucose Sensor.” JOURNAL OF BIOPHOTONICS 9.10 (2016): 1033–1043. Print.