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Mechanisms of immunomodulation by mammalian and viral decoy receptors : insights from structures

Jan Félix (UGent) and Savvas Savvides (UGent)
(2017) NATURE REVIEWS IMMUNOLOGY. 17(2). p.112-129
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Abstract
Immune responses are regulated by effector cytokines and chemokines that signal through cell surface receptors. Mammalian decoy receptors which are typically soluble or inactive versions of cell surface receptors or soluble protein modules termed binding proteins modulate and antagonize signalling by canonical effector-receptor complexes. Viruses have developed a diverse array of molecular decoys to evade host immune responses; these include viral homologues of host cytokines, chemokines and chemokine receptors; variants of host receptors with new functions; and novel decoy receptors that do not have host counterparts. Over the past decade, the number of known mammalian and viral decoy receptors has increased considerably, yet a comprehensive curation of the corresponding structure-mechanism relationships has not been carried out. In this Review, we provide a comprehensive resource on this topic with a view to better understanding the roles and evolutionary relationships of mammalian and viral decoy receptors, and the opportunities for leveraging their therapeutic potential.
Keywords
CHEMOKINE-BINDING-PROTEIN, NECROSIS-FACTOR RECEPTOR, SOLUBLE CYTOKINE, RECEPTORS, BROAD SPECIES-SPECIFICITY, COLONY-STIMULATING FACTOR, COWPOX, VIRUSES ENCODE, CRYSTAL-STRUCTURE, SIGNALING COMPLEX, VACCINIA VIRUS, TNF RECEPTOR

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MLA
Félix, Jan, and Savvas Savvides. “Mechanisms of Immunomodulation by Mammalian and Viral Decoy Receptors : Insights from Structures.” NATURE REVIEWS IMMUNOLOGY 17.2 (2017): 112–129. Print.
APA
Félix, J., & Savvides, S. (2017). Mechanisms of immunomodulation by mammalian and viral decoy receptors : insights from structures. NATURE REVIEWS IMMUNOLOGY, 17(2), 112–129.
Chicago author-date
Félix, Jan, and Savvas Savvides. 2017. “Mechanisms of Immunomodulation by Mammalian and Viral Decoy Receptors : Insights from Structures.” Nature Reviews Immunology 17 (2): 112–129.
Chicago author-date (all authors)
Félix, Jan, and Savvas Savvides. 2017. “Mechanisms of Immunomodulation by Mammalian and Viral Decoy Receptors : Insights from Structures.” Nature Reviews Immunology 17 (2): 112–129.
Vancouver
1.
Félix J, Savvides S. Mechanisms of immunomodulation by mammalian and viral decoy receptors : insights from structures. NATURE REVIEWS IMMUNOLOGY. 2017;17(2):112–29.
IEEE
[1]
J. Félix and S. Savvides, “Mechanisms of immunomodulation by mammalian and viral decoy receptors : insights from structures,” NATURE REVIEWS IMMUNOLOGY, vol. 17, no. 2, pp. 112–129, 2017.
@article{8514538,
  abstract     = {Immune responses are regulated by effector cytokines and chemokines that signal through cell surface receptors. Mammalian decoy receptors which are typically soluble or inactive versions of cell surface receptors or soluble protein modules termed binding proteins modulate and antagonize signalling by canonical effector-receptor complexes. Viruses have developed a diverse array of molecular decoys to evade host immune responses; these include viral homologues of host cytokines, chemokines and chemokine receptors; variants of host receptors with new functions; and novel decoy receptors that do not have host counterparts. Over the past decade, the number of known mammalian and viral decoy receptors has increased considerably, yet a comprehensive curation of the corresponding structure-mechanism relationships has not been carried out. In this Review, we provide a comprehensive resource on this topic with a view to better understanding the roles and evolutionary relationships of mammalian and viral decoy receptors, and the opportunities for leveraging their therapeutic potential.},
  author       = {Félix, Jan and Savvides, Savvas},
  issn         = {1474-1733},
  journal      = {NATURE REVIEWS IMMUNOLOGY},
  keywords     = {CHEMOKINE-BINDING-PROTEIN,NECROSIS-FACTOR RECEPTOR,SOLUBLE CYTOKINE,RECEPTORS,BROAD SPECIES-SPECIFICITY,COLONY-STIMULATING FACTOR,COWPOX,VIRUSES ENCODE,CRYSTAL-STRUCTURE,SIGNALING COMPLEX,VACCINIA VIRUS,TNF RECEPTOR},
  language     = {eng},
  number       = {2},
  pages        = {112--129},
  title        = {Mechanisms of immunomodulation by mammalian and viral decoy receptors : insights from structures},
  url          = {http://dx.doi.org/10.1038/nn.2016.134},
  volume       = {17},
  year         = {2017},
}

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