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Furan-PNA : a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

(2016) CHEMICAL COMMUNICATIONS. 52(42). p.6930-6933
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Abstract
We here report on the design and synthesis of tailor-made furan-modified peptide nucleic acid (PNA) probes for covalent targeting of single stranded DNA through a crosslinking strategy. After introducing furan-containing building blocks into a PNA sequence, hybridization and furan-oxidation based crosslinking to DNA is investigated. The structure of the crosslinked products is characterized and preliminary investigations concerning the application of these systems to double stranded DNA are shown.
Keywords
PEPTIDE NUCLEIC-ACIDS, CANCER-CELLS, TECHNOLOGY, MODULATION, EXPRESSION, CONJUGATE

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Citation

Please use this url to cite or link to this publication:

MLA
Manicardi, Alex et al. “Furan-PNA : a Mildly Inducible Irreversible Interstrand Crosslinking System Targeting Single and Double Stranded DNA.” CHEMICAL COMMUNICATIONS 52.42 (2016): 6930–6933. Print.
APA
Manicardi, A., Gyssels, E., Corradini, R., & Madder, A. (2016). Furan-PNA : a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA. CHEMICAL COMMUNICATIONS, 52(42), 6930–6933.
Chicago author-date
Manicardi, Alex, Ellen Gyssels, Roberto Corradini, and Annemieke Madder. 2016. “Furan-PNA : a Mildly Inducible Irreversible Interstrand Crosslinking System Targeting Single and Double Stranded DNA.” Chemical Communications 52 (42): 6930–6933.
Chicago author-date (all authors)
Manicardi, Alex, Ellen Gyssels, Roberto Corradini, and Annemieke Madder. 2016. “Furan-PNA : a Mildly Inducible Irreversible Interstrand Crosslinking System Targeting Single and Double Stranded DNA.” Chemical Communications 52 (42): 6930–6933.
Vancouver
1.
Manicardi A, Gyssels E, Corradini R, Madder A. Furan-PNA : a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA. CHEMICAL COMMUNICATIONS. 2016;52(42):6930–3.
IEEE
[1]
A. Manicardi, E. Gyssels, R. Corradini, and A. Madder, “Furan-PNA : a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA,” CHEMICAL COMMUNICATIONS, vol. 52, no. 42, pp. 6930–6933, 2016.
@article{8514053,
  abstract     = {We here report on the design and synthesis of tailor-made furan-modified peptide nucleic acid (PNA) probes for covalent targeting of single stranded DNA through a crosslinking strategy. After introducing furan-containing building blocks into a PNA sequence, hybridization and furan-oxidation based crosslinking to DNA is investigated. The structure of the crosslinked products is characterized and preliminary investigations concerning the application of these systems to double stranded DNA are shown.},
  author       = {Manicardi, Alex and Gyssels, Ellen and Corradini, Roberto and Madder, Annemieke},
  issn         = {1359-7345},
  journal      = {CHEMICAL COMMUNICATIONS},
  keywords     = {PEPTIDE NUCLEIC-ACIDS,CANCER-CELLS,TECHNOLOGY,MODULATION,EXPRESSION,CONJUGATE},
  language     = {eng},
  number       = {42},
  pages        = {6930--6933},
  title        = {Furan-PNA : a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA},
  url          = {http://dx.doi.org/10.1039/c6cc02062c},
  volume       = {52},
  year         = {2016},
}

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