Ghent University Academic Bibliography

@article{8513809,
  abstract     = {Background: Programmed cell death-1 (PD-1) is a negative regulator of T-cell responses. Expression of PD-1 and its ligands PD-L1 and PD-L2 in chronic rhinosinusitis with nasal polyps (CRSwNP) is poorly studied. 
Methods: Expression of PD-1, PD-L1, PD-L2, TGF-beta, IL-5, and IL-10 mRNA was measured by real-time quantitative PCR on tissue homogenates of patients with CRSwNP (n = 21) and healthy controls (n = 21) and on primary epithelial cells. Disease severity was scored using the Lund-Mackay scores of maxillofacial computed tomography (CT) scans. Expression of PD-1 and PD-L1/L2 was evaluated at the cellular and tissue levels (n = 6) by flow cytometry and immunohistochemistry. 
Results: Programmed cell death-1 mRNA expression was increased in tissue homogenates from patients with CRSwNP compared with controls, irrespective of the atopy status. Importantly, expression of PD-1 correlated with the total CT scan scores (r = 0.5, P = 0.02). Additionally, a significant association was found between PD-1 mRNA and expression of IL-5 mRNA in control nasal tissue (r = 0.95, P {\textlangle} 0.0001) and in CRSwNP (r = 0.63, P = 0.002). PD-1 was expressed on different subsets of T cells and CD11b(-) dendritic cells. Both PD-1 and its ligands were expressed on primary epithelial cells from control nasal tissue and nasal polyp tissue. 
Conclusions: Higher PD-1 expression was found in CRSwNP than in nasal tissue from controls. This was associated with disease severity and tissue IL-5 expression but unrelated to the patients' atopy status.},
  author       = {Kortekaas Krohn, I and Bobic, S and Dooley, J and Lan, Feng and Zhang, Nan and Bachert, Claus and Steelant, B and Bullens, DM and Liston, A and Ceuppens, JL and Seys, SF and Hellings, PW},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keyword      = {chronic rhinosinusitis,interleukin-5,nasal polyps,programmed cell death-1,radiologic severity,AIRWAY EPITHELIAL-CELLS,ALLERGIC DISEASES,B7 FAMILY,T-CELLS,IN-VIVO,ASTHMA,PD-1,ACTIVATION,INFECTION,RECEPTOR},
  language     = {eng},
  number       = {6},
  pages        = {985--993},
  title        = {Programmed cell death-1 expression correlates with disease severity and IL-5 in chronic rhinosinusitis with nasal polyps},
  url          = {http://dx.doi.org/10.1111/all.13136},
  volume       = {72},
  year         = {2017},
}

Chicago

Kortekaas Krohn, I, S Bobic, J Dooley, Feng Lan, Nan Zhang, Claus Bachert, B Steelant, et al. 2017. “Programmed Cell Death-1 Expression Correlates with Disease Severity and IL-5 in Chronic Rhinosinusitis with Nasal Polyps.” Allergy 72 (6): 985–993.

APA

Kortekaas Krohn, I., Bobic, S., Dooley, J., Lan, F., Zhang, N., Bachert, C., Steelant, B., et al. (2017). Programmed cell death-1 expression correlates with disease severity and IL-5 in chronic rhinosinusitis with nasal polyps. ALLERGY, 72(6), 985–993.

Vancouver

1.

Kortekaas Krohn I, Bobic S, Dooley J, Lan F, Zhang N, Bachert C, et al. Programmed cell death-1 expression correlates with disease severity and IL-5 in chronic rhinosinusitis with nasal polyps. ALLERGY. 2017;72(6):985–93.

MLA

Kortekaas Krohn, I, S Bobic, J Dooley, et al. “Programmed Cell Death-1 Expression Correlates with Disease Severity and IL-5 in Chronic Rhinosinusitis with Nasal Polyps.” ALLERGY 72.6 (2017): 985–993. Print.