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Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? : results from the Global Allergy and Asthma Network of Excellence (GA²LEN) survey

Vanessa Garcia-Larsen, Rhonda Arthur, James F Potts, Peter H Howarth, Matti Ahlström, Tari Haahtela, Carlos Loureiro, Ana Todo Bom, Grzegorz Brożek, Joanna Makowska, et al. (2017) CLINICAL AND TRANSLATIONAL ALLERGY. 7.
abstract
Background: Fruits and vegetables are rich in compounds with proposed antioxidant, anti-allergic and anti-inflammatory properties, which could contribute to reduce the prevalence of asthma and allergic diseases. Objective: We investigated the association between asthma, and chronic rhino-sinusitis (CRS) with intake of fruits and vegetables in European adults. Methods: A stratified random sample was drawn from the Global Allergy and Asthma Network of Excellence (GA(2)LEN) screening survey, in which 55,000 adults aged 15-75 answered a questionnaire on respiratory symptoms. Asthma score (derived from self-reported asthma symptoms) and CRS were the outcomes of interest. Dietary intake of 22 subgroups of fruits and vegetables was ascertained using the internationally validated GA(2)LEN Food Frequency Questionnaire. Adjusted associations were examined with negative binomial and multiple regressions. Simes procedure was used to control for multiple testing. Results: A total of 3206 individuals had valid data on asthma and dietary exposures of interest. 22.8% reported having at least 1 asthma symptom (asthma score >= 1), whilst 19.5% had CRS. After adjustment for potential confounders, asthma score was negatively associated with intake of dried fruits (beta-coefficient -2.34;95% confidence interval [CI] -4.09,-0.59), whilst CRS was statistically negatively associated with total intake of fruits (OR 0.73; 95% CI 0.55, 0.97). Conversely, a positive association was observed between asthma score and alliums vegetables (adjusted beta-coefficient 0.23; 95% CI 0.06, 0.40). None of these associations remained statistically significant after controlling for multiple testing. Conclusion and clinical relevance: There was no consistent evidence for an association of asthma or CRS with fruit and vegetable intake in this representative sample of European adults.
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author
organization
alternative title
Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? : results from the Global Allergy and Asthma Network of Excellence (GA2LEN) survey
year
type
journalArticle (original)
publication status
published
subject
keyword
Fruits, Vegetables, Asthma, Chronic rhino-sinusitis, Adults, Europe, Meta-analysis, GA(2)LEN, DIETARY ANTIOXIDANTS, PATTERNS, RISK, FLAVONOIDS, DISEASES
journal title
CLINICAL AND TRANSLATIONAL ALLERGY
Clin. Transl. Allergy
volume
7
article number
3
pages
9 pages
Web of Science type
Article
Web of Science id
000396072600001
ISSN
2045-7022
DOI
10.1186/s13601-016-0140-9
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8513673
handle
http://hdl.handle.net/1854/LU-8513673
date created
2017-03-09 15:34:25
date last changed
2017-09-06 14:24:19
@article{8513673,
  abstract     = {Background: Fruits and vegetables are rich in compounds with proposed antioxidant, anti-allergic and anti-inflammatory properties, which could contribute to reduce the prevalence of asthma and allergic diseases. 
Objective: We investigated the association between asthma, and chronic rhino-sinusitis (CRS) with intake of fruits and vegetables in European adults. 
Methods: A stratified random sample was drawn from the Global Allergy and Asthma Network of Excellence (GA(2)LEN) screening survey, in which 55,000 adults aged 15-75 answered a questionnaire on respiratory symptoms. Asthma score (derived from self-reported asthma symptoms) and CRS were the outcomes of interest. Dietary intake of 22 subgroups of fruits and vegetables was ascertained using the internationally validated GA(2)LEN Food Frequency Questionnaire. Adjusted associations were examined with negative binomial and multiple regressions. Simes procedure was used to control for multiple testing. 
Results: A total of 3206 individuals had valid data on asthma and dietary exposures of interest. 22.8\% reported having at least 1 asthma symptom (asthma score {\textrangle}= 1), whilst 19.5\% had CRS. After adjustment for potential confounders, asthma score was negatively associated with intake of dried fruits (beta-coefficient -2.34;95\% confidence interval [CI] -4.09,-0.59), whilst CRS was statistically negatively associated with total intake of fruits (OR 0.73; 95\% CI 0.55, 0.97). Conversely, a positive association was observed between asthma score and alliums vegetables (adjusted beta-coefficient 0.23; 95\% CI 0.06, 0.40). None of these associations remained statistically significant after controlling for multiple testing. 
Conclusion and clinical relevance: There was no consistent evidence for an association of asthma or CRS with fruit and vegetable intake in this representative sample of European adults.},
  articleno    = {3},
  author       = {Garcia-Larsen, Vanessa and Arthur, Rhonda and Potts, James F and Howarth, Peter H and Ahlstr{\"o}m, Matti and Haahtela, Tari and Loureiro, Carlos and Bom, Ana Todo and Bro\.{z}ek, Grzegorz and Makowska, Joanna and Kowalski, Marek L and Thilsing, Trine and Keil, Thomas and Matricardi, Paolo M and Tor{\'e}n, Kjell and Van Zele, Thibaut and Bachert, Claus and Rymarczyk, Barbara and Janson, Christer and Forsberg, Bertil and Ni\.{z}ankowska-Mogilnicka, Ewa and Burney, Peter GJ},
  issn         = {2045-7022},
  journal      = {CLINICAL AND TRANSLATIONAL ALLERGY},
  keyword      = {Fruits,Vegetables,Asthma,Chronic rhino-sinusitis,Adults,Europe,Meta-analysis,GA(2)LEN,DIETARY ANTIOXIDANTS,PATTERNS,RISK,FLAVONOIDS,DISEASES},
  language     = {eng},
  pages        = {9},
  title        = {Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? : results from the Global Allergy and Asthma Network of Excellence (GA{\texttwosuperior}LEN) survey},
  url          = {http://dx.doi.org/10.1186/s13601-016-0140-9},
  volume       = {7},
  year         = {2017},
}

Chicago
Garcia-Larsen, Vanessa, Rhonda Arthur, James F Potts, Peter H Howarth, Matti Ahlström, Tari Haahtela, Carlos Loureiro, et al. 2017. “Is Fruit and Vegetable Intake Associated with Asthma or Chronic Rhino-sinusitis in European Adults? : Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey.” Clinical and Translational Allergy 7.
APA
Garcia-Larsen, V., Arthur, R., Potts, J. F., Howarth, P. H., Ahlström, M., Haahtela, T., Loureiro, C., et al. (2017). Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? : results from the Global Allergy and Asthma Network of Excellence (GA2LEN) survey. CLINICAL AND TRANSLATIONAL ALLERGY, 7.
Vancouver
1.
Garcia-Larsen V, Arthur R, Potts JF, Howarth PH, Ahlström M, Haahtela T, et al. Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? : results from the Global Allergy and Asthma Network of Excellence (GA2LEN) survey. CLINICAL AND TRANSLATIONAL ALLERGY. 2017;7.
MLA
Garcia-Larsen, Vanessa, Rhonda Arthur, James F Potts, et al. “Is Fruit and Vegetable Intake Associated with Asthma or Chronic Rhino-sinusitis in European Adults? : Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey.” CLINICAL AND TRANSLATIONAL ALLERGY 7 (2017): n. pag. Print.