Advanced search
1 file | 124.55 KB

Fibromuscular dysplasia : results of a multicentre study in Flanders

Author
Organization
Abstract
Background: Fibromuscular dysplasia (FMD) is an idiopathic, non-inflammatory, non-atherosclerotic vascular disease, resulting in focal narrowing of small and medium-sized arteries. Systematic recording of clinical data in central databases as in the US and France provided new insights into FMD. The main objectives of this multicentre study were to explore the epidemiology, pattern of vascular involvement, clinical manifestations, and management of FMD patients in Flanders. Patients and methods: Multicentre, retrospective registry of patients diagnosed with FMD based on medical imaging. Results: Hundred-twenty-three FMD patients (83.7 % female) were included. Mean age at FMD diagnosis was 57.3 years (SD 15.8). More than half of patients (59.5%) were hypertensive at the time of diagnosis. Neurological complaints such as headache (26.4%) and dizziness (23.1%) were also frequently reported. FMD was discovered incidentally in 10 patients (8.3%). Nearly one quarter (22.8%) of patients experienced a cerebrovascular event. Aneurysms were found in one-fifth (20.3 %) of patients and 11.4% had an arterial dissection. FMD affected. most frequently the renal (85.3 %), carotid (74.7 %), and vertebral (39.8%) arteries. Renovascular FMD was more prevalent in men, whereas cerebrovascular FMD was more frequent in women. Multiple affected sites were documented in 25 of 61 (41.0%) patients, having two or more vascular beds imaged. Digital subtraction angiography was most frequently used for detecting FMD. One third (32.9%) of patients received an interventional treatment, mainly patients with renovascular FMD (32.8% underwent percutaneous transluminal angioplasty) and patients with an intracranial carotid aneurysm (36.4% were treated by means of coiling). Conclusions: Although differences existed, results of the Flemish registry were broadly in line with the US and French registries. Patient databases help to learn more about the natural history, progression, and management of FMD, based on real life clinical evidence.
Keywords
Fibromuscular dysplasia, registries, medical imaging, renovascular, cerebrovascular, CORONARY-ARTERY DISSECTION, UNITED-STATES REGISTRY, ASSOCIATION, MANAGEMENT, PREVALENCE, GUIDELINES, DIAGNOSIS, ANEURYSMS, DISEASE

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 124.55 KB

Citation

Please use this url to cite or link to this publication:

Chicago
De Groote, Marie, Patricia Van der Niepen, Dimitri Hemelsoet, Bert Callewaert, Frank Vermassen, Jean-Marie Billiouw, An De Vriese, Jan Donck, and Tine De Backer. 2017. “Fibromuscular Dysplasia : Results of a Multicentre Study in Flanders.” Vasa-european Journal of Vascular Medicine 46 (3): 211–218.
APA
De Groote, Marie, Van der Niepen, P., Hemelsoet, D., Callewaert, B., Vermassen, F., Billiouw, J.-M., De Vriese, A., et al. (2017). Fibromuscular dysplasia : results of a multicentre study in Flanders. VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE, 46(3), 211–218.
Vancouver
1.
De Groote M, Van der Niepen P, Hemelsoet D, Callewaert B, Vermassen F, Billiouw J-M, et al. Fibromuscular dysplasia : results of a multicentre study in Flanders. VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE. 2017;46(3):211–8.
MLA
De Groote, Marie, Patricia Van der Niepen, Dimitri Hemelsoet, et al. “Fibromuscular Dysplasia : Results of a Multicentre Study in Flanders.” VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE 46.3 (2017): 211–218. Print.
@article{8513630,
  abstract     = {Background: Fibromuscular dysplasia (FMD) is an idiopathic, non-inflammatory, non-atherosclerotic vascular disease, resulting in focal narrowing of small and medium-sized arteries. Systematic recording of clinical data in central databases as in the US and France provided new insights into FMD. The main objectives of this multicentre study were to explore the epidemiology, pattern of vascular involvement, clinical manifestations, and management of FMD patients in Flanders.
Patients and methods: Multicentre, retrospective registry of patients diagnosed with FMD based on medical imaging.
Results: Hundred-twenty-three FMD patients (83.7 \% female) were included. Mean age at FMD diagnosis was 57.3 years (SD 15.8). More than half of patients (59.5\%) were hypertensive at the time of diagnosis. Neurological complaints such as headache (26.4\%) and dizziness (23.1\%) were also frequently reported. FMD was discovered incidentally in 10 patients (8.3\%). Nearly one quarter (22.8\%) of patients experienced a cerebrovascular event. Aneurysms were found in one-fifth (20.3 \%) of patients and 11.4\% had an arterial dissection. FMD affected. most frequently the renal (85.3 \%), carotid (74.7 \%), and vertebral (39.8\%) arteries. Renovascular FMD was more prevalent in men, whereas cerebrovascular FMD was more frequent in women. Multiple affected sites were documented in 25 of 61 (41.0\%) patients, having two or more vascular beds imaged. Digital subtraction angiography was most frequently used for detecting FMD. One third (32.9\%) of patients received an interventional treatment, mainly patients with renovascular FMD (32.8\% underwent percutaneous transluminal angioplasty) and patients with an intracranial carotid aneurysm (36.4\% were treated by means of coiling).
Conclusions: Although differences existed, results of the Flemish registry were broadly in line with the US and French registries. Patient databases help to learn more about the natural history, progression, and management of FMD, based on real life clinical evidence.},
  author       = {De Groote, Marie and Van der Niepen, Patricia and Hemelsoet, Dimitri and Callewaert, Bert and Vermassen, Frank and Billiouw, Jean-Marie and De Vriese, An and Donck, Jan and De Backer, Tine},
  issn         = {0301-1526},
  journal      = {VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE},
  language     = {eng},
  number       = {3},
  pages        = {211--218},
  title        = {Fibromuscular dysplasia : results of a multicentre study in Flanders},
  url          = {http://dx.doi.org/10.1024/0301-1526/a000613},
  volume       = {46},
  year         = {2017},
}

Altmetric
View in Altmetric
Web of Science
Times cited: