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Cure of cancer for seven cancer sites in the Flemish Region

Geert Silversmit, David Jegou, Evelien Vaes, Els Goetghebeur UGent and Liesbet Van Eycken (2017) INTERNATIONAL JOURNAL OF CANCER. 140(5). p.1102-1110
abstract
Cumulative relative survival curves for many cancers reach a plateau several years after diagnosis, indicating that the cancer survivor group has reached "statistical" cure. Parametric mixture cure model analysis on grouped relative survival curves provide an interesting way to determine the proportion of statistically cured cases and the mean survival time of the fatal cases in particular for population-based cancer registries. Based on the relative survival data from the Belgian Cancer Registry, parametric cure models were applied to seven cancer sites (cervix, colon, corpus uteri, skin melanoma, pancreas, stomach and oesophagus), at the Flemish Regional level for the incidence period 1999-2011. Statistical cure was observed for the examined cancer sites except for oesophageal cancer. The estimated cured proportion ranged from 5.9% [5.7, 6.1] for pancreatic cancer to 80.8% [80.5, 81.2] for skin melanoma. Cure results were further stratified by gender or age group. Stratified cured proportions were higher for females compared to males in colon cancer, stomach cancer, pancreas cancer and skin melanoma, which can mainly be attributed to differences in stage and age distribution between both sexes. This study demonstrates the applicability of cure rate models for the selected cancer sites after 14 years of follow-up and presents the first population-based results on the cure of cancer in Belgium.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
cure of cancer, relative survival, parametric mixture cure models, population based, Flanders, POPULATION-BASED-CANCER, LONG-TERM SURVIVAL, COMPETING RISKS, PROPORTION, MODELS, DEATHS, TRENDS, COLON
journal title
INTERNATIONAL JOURNAL OF CANCER
Int. J. Cancer
volume
140
issue
5
pages
1102 - 1110
Web of Science type
Article
Web of Science id
000393976100013
ISSN
0020-7136
DOI
10.1002/ijc.30532
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8513054
handle
http://hdl.handle.net/1854/LU-8513054
date created
2017-03-07 14:48:55
date last changed
2017-04-13 14:06:51
@article{8513054,
  abstract     = {Cumulative relative survival curves for many cancers reach a plateau several years after diagnosis, indicating that the cancer survivor group has reached {\textacutedbl}statistical{\textacutedbl} cure. Parametric mixture cure model analysis on grouped relative survival curves provide an interesting way to determine the proportion of statistically cured cases and the mean survival time of the fatal cases in particular for population-based cancer registries. Based on the relative survival data from the Belgian Cancer Registry, parametric cure models were applied to seven cancer sites (cervix, colon, corpus uteri, skin melanoma, pancreas, stomach and oesophagus), at the Flemish Regional level for the incidence period 1999-2011. Statistical cure was observed for the examined cancer sites except for oesophageal cancer. The estimated cured proportion ranged from 5.9\% [5.7, 6.1] for pancreatic cancer to 80.8\% [80.5, 81.2] for skin melanoma. Cure results were further stratified by gender or age group. Stratified cured proportions were higher for females compared to males in colon cancer, stomach cancer, pancreas cancer and skin melanoma, which can mainly be attributed to differences in stage and age distribution between both sexes. This study demonstrates the applicability of cure rate models for the selected cancer sites after 14 years of follow-up and presents the first population-based results on the cure of cancer in Belgium.},
  author       = {Silversmit, Geert and Jegou, David and Vaes, Evelien and Goetghebeur, Els and Van Eycken, Liesbet},
  issn         = {0020-7136},
  journal      = {INTERNATIONAL JOURNAL OF CANCER},
  keyword      = {cure of cancer,relative survival,parametric mixture cure models,population based,Flanders,POPULATION-BASED-CANCER,LONG-TERM SURVIVAL,COMPETING RISKS,PROPORTION,MODELS,DEATHS,TRENDS,COLON},
  language     = {eng},
  number       = {5},
  pages        = {1102--1110},
  title        = {Cure of cancer for seven cancer sites in the Flemish Region},
  url          = {http://dx.doi.org/10.1002/ijc.30532},
  volume       = {140},
  year         = {2017},
}

Chicago
Silversmit, Geert, David Jegou, Evelien Vaes, Els Goetghebeur, and Liesbet Van Eycken. 2017. “Cure of Cancer for Seven Cancer Sites in the Flemish Region.” International Journal of Cancer 140 (5): 1102–1110.
APA
Silversmit, G., Jegou, D., Vaes, E., Goetghebeur, E., & Van Eycken, L. (2017). Cure of cancer for seven cancer sites in the Flemish Region. INTERNATIONAL JOURNAL OF CANCER, 140(5), 1102–1110.
Vancouver
1.
Silversmit G, Jegou D, Vaes E, Goetghebeur E, Van Eycken L. Cure of cancer for seven cancer sites in the Flemish Region. INTERNATIONAL JOURNAL OF CANCER. 2017;140(5):1102–10.
MLA
Silversmit, Geert, David Jegou, Evelien Vaes, et al. “Cure of Cancer for Seven Cancer Sites in the Flemish Region.” INTERNATIONAL JOURNAL OF CANCER 140.5 (2017): 1102–1110. Print.