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Healthy brain ageing assessed with 18F-FDG PET and age-dependent recovery factors after partial volume effect correction

Stijn Bonte (UGent) , Pieter Vandemaele (UGent) , Stijn Verleden (UGent) , Kurt Audenaert (UGent) , Karel Deblaere (UGent) , Ingeborg Goethals (UGent) and Roel Van Holen (UGent)
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Abstract
Context and purpose: The mechanisms of ageing of the healthy brain are not entirely clarified to date. In recent years several authors have tried to elucidate this topic by using F-18-FDG positron emission tomography. However, when correcting for partial volume effects (PVE), divergent results were reported. Therefore, it is necessary to evaluate these methods in the presence of atrophy due to ageing. In this paper we first evaluate the performance of two PVE correction techniques with a phantom study: the Rousset method and iterative deconvolution. We show that the ability of the latter method to recover the true activity in a small region decreases with increasing age due to brain atrophy. Next, we have calculated age-dependent recovery factors to correct for this incomplete recovery. These factors were applied to PVE-corrected F-18-FDG PET scans of healthy subjects for mapping the age-dependent metabolism in the brain. Results: Many regions in the brain show a reduced metabolism with ageing, especially in grey matter in the frontal and temporal lobe. An increased metabolism is found in grey matter of the cerebellum and thalamus. Conclusion: Our study resulted in age-dependent recovery factors which can be applied following standard PVE correction methods. Cancelling the effect of atrophy, we found regional changes in F-18-FDG metabolism with ageing. A decreasing trend is found in the frontal and temporal lobe, whereas an increasing metabolism with ageing is observed in the thalamus and cerebellum.
Keywords
Age, F-18-FDG PET, Healthy subject, PVE correction, POSITRON-EMISSION-TOMOGRAPHY, CEREBRAL GLUCOSE-METABOLISM, GRAY-MATTER, FDG-PET, ELDERLY SUBJECTS, SEX, SEGMENTATION, VALIDATION, JAPANESE, DECLINE

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Chicago
Bonte, Stijn, Pieter Vandemaele, Stijn Verleden, Kurt Audenaert, Karel Deblaere, Ingeborg Goethals, and Roel Van Holen. 2017. “Healthy Brain Ageing Assessed with 18F-FDG PET and Age-dependent Recovery Factors After Partial Volume Effect Correction.” European Journal of Nuclear Medicine and Molecular Imaging 44 (5): 838–849.
APA
Bonte, Stijn, Vandemaele, P., Verleden, S., Audenaert, K., Deblaere, K., Goethals, I., & Van Holen, R. (2017). Healthy brain ageing assessed with 18F-FDG PET and age-dependent recovery factors after partial volume effect correction. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 44(5), 838–849.
Vancouver
1.
Bonte S, Vandemaele P, Verleden S, Audenaert K, Deblaere K, Goethals I, et al. Healthy brain ageing assessed with 18F-FDG PET and age-dependent recovery factors after partial volume effect correction. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2017;44(5):838–49.
MLA
Bonte, Stijn, Pieter Vandemaele, Stijn Verleden, et al. “Healthy Brain Ageing Assessed with 18F-FDG PET and Age-dependent Recovery Factors After Partial Volume Effect Correction.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 44.5 (2017): 838–849. Print.
@article{8512864,
  abstract     = {Context and purpose: The mechanisms of ageing of the healthy brain are not entirely clarified to date. In recent years several authors have tried to elucidate this topic by using F-18-FDG positron emission tomography. However, when correcting for partial volume effects (PVE), divergent results were reported. Therefore, it is necessary to evaluate these methods in the presence of atrophy due to ageing. In this paper we first evaluate the performance of two PVE correction techniques with a phantom study: the Rousset method and iterative deconvolution. We show that the ability of the latter method to recover the true activity in a small region decreases with increasing age due to brain atrophy. Next, we have calculated age-dependent recovery factors to correct for this incomplete recovery. These factors were applied to PVE-corrected F-18-FDG PET scans of healthy subjects for mapping the age-dependent metabolism in the brain. 
Results: Many regions in the brain show a reduced metabolism with ageing, especially in grey matter in the frontal and temporal lobe. An increased metabolism is found in grey matter of the cerebellum and thalamus.
Conclusion: Our study resulted in age-dependent recovery factors which can be applied following standard PVE correction methods. Cancelling the effect of atrophy, we found regional changes in F-18-FDG metabolism with ageing. A decreasing trend is found in the frontal and temporal lobe, whereas an increasing metabolism with ageing is observed in the thalamus and cerebellum.},
  author       = {Bonte, Stijn and Vandemaele, Pieter and Verleden, Stijn and Audenaert, Kurt and Deblaere, Karel and Goethals, Ingeborg and Van Holen, Roel},
  issn         = {1619-7070},
  journal      = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING},
  keyword      = {Age,F-18-FDG PET,Healthy subject,PVE correction,POSITRON-EMISSION-TOMOGRAPHY,CEREBRAL GLUCOSE-METABOLISM,GRAY-MATTER,FDG-PET,ELDERLY SUBJECTS,SEX,SEGMENTATION,VALIDATION,JAPANESE,DECLINE},
  language     = {eng},
  number       = {5},
  pages        = {838--849},
  title        = {Healthy brain ageing assessed with 18F-FDG PET and age-dependent recovery factors after partial volume effect correction},
  url          = {http://dx.doi.org/10.1007/s00259-016-3569-0},
  volume       = {44},
  year         = {2017},
}

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