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Mapping EQ-5D utilities to GBD 2010 and GBD 2013 disability weights : results of two pilot studies in Belgium

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Abstract
Background: Utilities and disability weights (DWs) are metrics used for calculating Quality-Adjusted Life Years and Disability-Adjusted Life Years (DALYs), respectively. Utilities can be obtained with multi-attribute instruments such as the EuroQol 5 dimensions questionnaire (EQ-5D). In 2010 and 2013, Salomon et al. proposed a set of DWs for 220 and 183 health states, respectively. The objective of this study is to develop an approach for mapping EQ-5D utilities to existing GBD 2010 and GBD 2013 DWs, allowing to predict new GBD 2010/2013 DWs based on EQ-5D utilities. Methods: We conducted two pilot studies including respectively four and twenty-seven health states selected from the 220 DWs of the GBD 2010 study. In the first study, each participant evaluated four health conditions using the standard written EQ-5D-5 L questionnaire. In the second study, each participant evaluated four health conditions randomly selected among the twenty-seven health states using a previously developed web-based EQ-5D-5 L questionnaire. The EQ-5D responses were translated into utilities using the model developed by Cleemput et al. A loess regression allowed to map EQ-5D utilities to logit transformed DWs. Results: Overall, 81 and 393 respondents completed the first and the second survey, respectively. In the first study, a monotonic relationship between derived utilities and predicted GBD 2010/2013 DWs was observed, but not in the second study. There were some important differences in ranking of health states based on utilities versus GBD 2010/2013 DWs. The participants of the current study attributed a relatively higher severity level to musculoskeletal disorders such as ‘Amputation of both legs’ and a relatively lower severity level to non-functional disorders such as ‘Headache migraine’ compared to the participants of the GBD 2010/2013 studies. Conclusion: This study suggests the possibility to translate any utility derived from EQ-5D scores into a DW, but also highlights important caveats. We observed a satisfactory result of this methodology when utilities were derived from a population of public health students, a written questionnaire and a small number of health states in the presence of a study leader. However the results were unsatisfactory when utilities were derived from a sample of the general population, using a web-based questionnaire. We recommend to repeat the study in a larger and more diverse sample to obtain a more representative distribution of educational level and age.
Keywords
EQ-5D, Utilities, GBD2010, GBD2013, DW, Mapping

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MLA
Maertens de Noordhout, Charline, Brecht Devleesschauwer, Leslie Gielens, et al. “Mapping EQ-5D Utilities to GBD 2010 and GBD 2013 Disability Weights : Results of Two Pilot Studies in Belgium.” ARCHIVES OF PUBLIC HEALTH 75 (2017): n. pag. Print.
APA
Maertens de Noordhout, C., Devleesschauwer, B., Gielens, L., Plasmans, M. H., Haagsma, J. A., & Speybroeck, N. (2017). Mapping EQ-5D utilities to GBD 2010 and GBD 2013 disability weights : results of two pilot studies in Belgium. ARCHIVES OF PUBLIC HEALTH, 75.
Chicago author-date
Maertens de Noordhout, Charline, Brecht Devleesschauwer, Leslie Gielens, Marjanne HD Plasmans, Juanita A Haagsma, and Niko Speybroeck. 2017. “Mapping EQ-5D Utilities to GBD 2010 and GBD 2013 Disability Weights : Results of Two Pilot Studies in Belgium.” Archives of Public Health 75.
Chicago author-date (all authors)
Maertens de Noordhout, Charline, Brecht Devleesschauwer, Leslie Gielens, Marjanne HD Plasmans, Juanita A Haagsma, and Niko Speybroeck. 2017. “Mapping EQ-5D Utilities to GBD 2010 and GBD 2013 Disability Weights : Results of Two Pilot Studies in Belgium.” Archives of Public Health 75.
Vancouver
1.
Maertens de Noordhout C, Devleesschauwer B, Gielens L, Plasmans MH, Haagsma JA, Speybroeck N. Mapping EQ-5D utilities to GBD 2010 and GBD 2013 disability weights : results of two pilot studies in Belgium. ARCHIVES OF PUBLIC HEALTH. 2017;75.
IEEE
[1]
C. Maertens de Noordhout, B. Devleesschauwer, L. Gielens, M. H. Plasmans, J. A. Haagsma, and N. Speybroeck, “Mapping EQ-5D utilities to GBD 2010 and GBD 2013 disability weights : results of two pilot studies in Belgium,” ARCHIVES OF PUBLIC HEALTH, vol. 75, 2017.
@article{8511616,
  abstract     = {Background: Utilities and disability weights (DWs) are metrics used for calculating Quality-Adjusted Life Years and Disability-Adjusted Life Years (DALYs), respectively. Utilities can be obtained with multi-attribute instruments such as the EuroQol 5 dimensions questionnaire (EQ-5D). In 2010 and 2013, Salomon et al. proposed a set of DWs for 220 and 183 health states, respectively. The objective of this study is to develop an approach for mapping EQ-5D utilities to existing GBD 2010 and GBD 2013 DWs, allowing to predict new GBD 2010/2013 DWs based on EQ-5D utilities.
Methods: We conducted two pilot studies including respectively four and twenty-seven health states selected from the 220 DWs of the GBD 2010 study. In the first study, each participant evaluated four health conditions using the standard written EQ-5D-5 L questionnaire. In the second study, each participant evaluated four health conditions randomly selected among the twenty-seven health states using a previously developed web-based EQ-5D-5 L questionnaire. The EQ-5D responses were translated into utilities using the model developed by Cleemput et al. A loess regression allowed to map EQ-5D utilities to logit transformed DWs.
Results: Overall, 81 and 393 respondents completed the first and the second survey, respectively. In the first study, a monotonic relationship between derived utilities and predicted GBD 2010/2013 DWs was observed, but not in the second study. There were some important differences in ranking of health states based on utilities versus GBD 2010/2013 DWs. The participants of the current study attributed a relatively higher severity level to musculoskeletal disorders such as ‘Amputation of both legs’ and a relatively lower severity level to non-functional disorders such as ‘Headache migraine’ compared to the participants of the GBD 2010/2013 studies.
Conclusion: This study suggests the possibility to translate any utility derived from EQ-5D scores into a DW, but also highlights important caveats. We observed a satisfactory result of this methodology when utilities were derived from a population of public health students, a written questionnaire and a small number of health states in the presence of a study leader. However the results were unsatisfactory when utilities were derived from a sample of the general population, using a web-based questionnaire. We recommend to repeat the study in a larger and more diverse sample to obtain a more representative distribution of educational level and age.},
  articleno    = {6},
  author       = {Maertens de Noordhout, Charline and Devleesschauwer, Brecht and Gielens, Leslie and Plasmans, Marjanne HD and Haagsma, Juanita A and Speybroeck, Niko},
  issn         = {2049-3258},
  journal      = {ARCHIVES OF PUBLIC HEALTH},
  keywords     = {EQ-5D,Utilities,GBD2010,GBD2013,DW,Mapping},
  language     = {eng},
  pages        = {12},
  title        = {Mapping EQ-5D utilities to GBD 2010 and GBD 2013 disability weights : results of two pilot studies in Belgium},
  url          = {http://dx.doi.org/10.1186/s13690-017-0174-z},
  volume       = {75},
  year         = {2017},
}

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