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Global stability of a class of futile cycles

Shodhan Rao (UGent)
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Abstract
In this paper, we prove the global asymptotic stability of a class of mass action futile cycle networks which includes a model of processive multisite phosphorylation networks. The proof consists of two parts. In the first part, we prove that there is a unique equilibrium in every positive compatibility class. In the second part, we make use of a piecewise linear in rates Lyapunov function in order to prove the global asymptotic stability of the unique equilibrium corresponding to a given initial concentration vector. The main novelty of the paper is the use of a simple algebraic approach based on the intermediate value property of continuous functions in order to prove the uniqueness of equilibrium in every positive compatibility class.
Keywords
Futile cycles, processive multisite phosphorylation, mass action kinetics, intermediate value property, piecewise linear in rates Lyapunov functions, LaSalle's invariance principle, LINEAR COMPARTMENTAL SYSTEMS, CHEMICAL-REACTION NETWORKS, LYAPUNOV FUNCTIONS, CONVERGENCE RESULT, STEADY-STATES, PHOSPHORYLATION, MECHANISMS

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Please use this url to cite or link to this publication:

MLA
Rao, Shodhan. “Global Stability of a Class of Futile Cycles.” JOURNAL OF MATHEMATICAL BIOLOGY, vol. 74, no. 3, 2017, pp. 709–26, doi:10.1007/s00285-016-1039-8.
APA
Rao, S. (2017). Global stability of a class of futile cycles. JOURNAL OF MATHEMATICAL BIOLOGY, 74(3), 709–726. https://doi.org/10.1007/s00285-016-1039-8
Chicago author-date
Rao, Shodhan. 2017. “Global Stability of a Class of Futile Cycles.” JOURNAL OF MATHEMATICAL BIOLOGY 74 (3): 709–26. https://doi.org/10.1007/s00285-016-1039-8.
Chicago author-date (all authors)
Rao, Shodhan. 2017. “Global Stability of a Class of Futile Cycles.” JOURNAL OF MATHEMATICAL BIOLOGY 74 (3): 709–726. doi:10.1007/s00285-016-1039-8.
Vancouver
1.
Rao S. Global stability of a class of futile cycles. JOURNAL OF MATHEMATICAL BIOLOGY. 2017;74(3):709–26.
IEEE
[1]
S. Rao, “Global stability of a class of futile cycles,” JOURNAL OF MATHEMATICAL BIOLOGY, vol. 74, no. 3, pp. 709–726, 2017.
@article{8511615,
  abstract     = {{In this paper, we prove the global asymptotic stability of a class of mass action futile cycle networks which includes a model of processive multisite phosphorylation networks. The proof consists of two parts. In the first part, we prove that there is a unique equilibrium in every positive compatibility class. In the second part, we make use of a piecewise linear in rates Lyapunov function in order to prove the global asymptotic stability of the unique equilibrium corresponding to a given initial concentration vector. The main novelty of the paper is the use of a simple algebraic approach based on the intermediate value property of continuous functions in order to prove the uniqueness of equilibrium in every positive compatibility class.}},
  author       = {{Rao, Shodhan}},
  issn         = {{0303-6812}},
  journal      = {{JOURNAL OF MATHEMATICAL BIOLOGY}},
  keywords     = {{Futile cycles,processive multisite phosphorylation,mass action kinetics,intermediate value property,piecewise linear in rates Lyapunov functions,LaSalle's invariance principle,LINEAR COMPARTMENTAL SYSTEMS,CHEMICAL-REACTION NETWORKS,LYAPUNOV FUNCTIONS,CONVERGENCE RESULT,STEADY-STATES,PHOSPHORYLATION,MECHANISMS}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{709--726}},
  title        = {{Global stability of a class of futile cycles}},
  url          = {{http://doi.org/10.1007/s00285-016-1039-8}},
  volume       = {{74}},
  year         = {{2017}},
}

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