Global stability of a class of futile cycles
- Author
- Shodhan Rao (UGent)
- Organization
- Abstract
- In this paper, we prove the global asymptotic stability of a class of mass action futile cycle networks which includes a model of processive multisite phosphorylation networks. The proof consists of two parts. In the first part, we prove that there is a unique equilibrium in every positive compatibility class. In the second part, we make use of a piecewise linear in rates Lyapunov function in order to prove the global asymptotic stability of the unique equilibrium corresponding to a given initial concentration vector. The main novelty of the paper is the use of a simple algebraic approach based on the intermediate value property of continuous functions in order to prove the uniqueness of equilibrium in every positive compatibility class.
- Keywords
- Futile cycles, processive multisite phosphorylation, mass action kinetics, intermediate value property, piecewise linear in rates Lyapunov functions, LaSalle's invariance principle, LINEAR COMPARTMENTAL SYSTEMS, CHEMICAL-REACTION NETWORKS, LYAPUNOV FUNCTIONS, CONVERGENCE RESULT, STEADY-STATES, PHOSPHORYLATION, MECHANISMS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8511615
- MLA
- Rao, Shodhan. “Global Stability of a Class of Futile Cycles.” JOURNAL OF MATHEMATICAL BIOLOGY, vol. 74, no. 3, 2017, pp. 709–26, doi:10.1007/s00285-016-1039-8.
- APA
- Rao, S. (2017). Global stability of a class of futile cycles. JOURNAL OF MATHEMATICAL BIOLOGY, 74(3), 709–726. https://doi.org/10.1007/s00285-016-1039-8
- Chicago author-date
- Rao, Shodhan. 2017. “Global Stability of a Class of Futile Cycles.” JOURNAL OF MATHEMATICAL BIOLOGY 74 (3): 709–26. https://doi.org/10.1007/s00285-016-1039-8.
- Chicago author-date (all authors)
- Rao, Shodhan. 2017. “Global Stability of a Class of Futile Cycles.” JOURNAL OF MATHEMATICAL BIOLOGY 74 (3): 709–726. doi:10.1007/s00285-016-1039-8.
- Vancouver
- 1.Rao S. Global stability of a class of futile cycles. JOURNAL OF MATHEMATICAL BIOLOGY. 2017;74(3):709–26.
- IEEE
- [1]S. Rao, “Global stability of a class of futile cycles,” JOURNAL OF MATHEMATICAL BIOLOGY, vol. 74, no. 3, pp. 709–726, 2017.
@article{8511615,
abstract = {{In this paper, we prove the global asymptotic stability of a class of mass action futile cycle networks which includes a model of processive multisite phosphorylation networks. The proof consists of two parts. In the first part, we prove that there is a unique equilibrium in every positive compatibility class. In the second part, we make use of a piecewise linear in rates Lyapunov function in order to prove the global asymptotic stability of the unique equilibrium corresponding to a given initial concentration vector. The main novelty of the paper is the use of a simple algebraic approach based on the intermediate value property of continuous functions in order to prove the uniqueness of equilibrium in every positive compatibility class.}},
author = {{Rao, Shodhan}},
issn = {{0303-6812}},
journal = {{JOURNAL OF MATHEMATICAL BIOLOGY}},
keywords = {{Futile cycles,processive multisite phosphorylation,mass action kinetics,intermediate value property,piecewise linear in rates Lyapunov functions,LaSalle's invariance principle,LINEAR COMPARTMENTAL SYSTEMS,CHEMICAL-REACTION NETWORKS,LYAPUNOV FUNCTIONS,CONVERGENCE RESULT,STEADY-STATES,PHOSPHORYLATION,MECHANISMS}},
language = {{eng}},
number = {{3}},
pages = {{709--726}},
title = {{Global stability of a class of futile cycles}},
url = {{http://doi.org/10.1007/s00285-016-1039-8}},
volume = {{74}},
year = {{2017}},
}
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