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Bacteria isolated from lung modulate asthma susceptibility in mice

Aude Remot, Delphyne Descamps, Marie-Louise Noordine, Abdelhak Boukadiri, Elliot Mathieu, Véronique Robert, Sabine Riffault, Bart Lambrecht UGent, Philippe Langella, Hamida Hammad UGent, et al. (2017) ISME JOURNAL. 11(5). p.1061-1074
abstract
Asthma is a chronic, non-curable, multifactorial disease with increasing incidence in industrial countries. This study evaluates the direct contribution of lung microbial components in allergic asthma in mice. Germ-Free and Specific-Pathogen-Free mice display similar susceptibilities to House Dust Mice-induced allergic asthma, indicating that the absence of bacteria confers no protection or increased risk to aeroallergens. In early life, allergic asthma changes the pattern of lung microbiota, and lung bacteria reciprocally modulate aeroallergen responsiveness. Primo-colonizing cultivable strains were screened for their immunoregulatory properties following their isolation from neonatal lungs. Intranasal inoculation of lung bacteria influenced the outcome of allergic asthma development: the strain CNCM I 4970 exacerbated some asthma features whereas the pro-Th1 strain CNCM I 4969 had protective effects. Thus, we confirm that appropriate bacterial lung stimuli during early life are critical for susceptibility to allergic asthma in young adults.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
GUT MICROBIOTA, COLONIC EPITHELIUM, ALLERGIC DISEASES, AIRWAY MICROBIOME, DENDRITIC CELLS, IMMUNE-SYSTEM, EARLY-LIFE, RESPONSES, COLONIZATION, INFLAMMATION
journal title
ISME JOURNAL
ISME J.
volume
11
issue
5
pages
1061 - 1074
Web of Science type
Article
Web of Science id
000399379500002
ISSN
1751-7362
1751-7370
DOI
10.1038/ismej.2016.181
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8511470
handle
http://hdl.handle.net/1854/LU-8511470
date created
2017-02-27 12:56:06
date last changed
2017-06-09 10:53:29
@article{8511470,
  abstract     = {Asthma is a chronic, non-curable, multifactorial disease with increasing incidence in industrial countries. This study evaluates the direct contribution of lung microbial components in allergic asthma in mice. Germ-Free and Specific-Pathogen-Free mice display similar susceptibilities to House Dust Mice-induced allergic asthma, indicating that the absence of bacteria confers no protection or increased risk to aeroallergens. In early life, allergic asthma changes the pattern of lung microbiota, and lung bacteria reciprocally modulate aeroallergen responsiveness. Primo-colonizing cultivable strains were screened for their immunoregulatory properties following their isolation from neonatal lungs. Intranasal inoculation of lung bacteria influenced the outcome of allergic asthma development: the strain CNCM I 4970 exacerbated some asthma features whereas the pro-Th1 strain CNCM I 4969 had protective effects. Thus, we confirm that appropriate bacterial lung stimuli during early life are critical for susceptibility to allergic asthma in young adults.},
  author       = {Remot, Aude and Descamps, Delphyne and Noordine, Marie-Louise and Boukadiri, Abdelhak and Mathieu, Elliot and Robert, V{\'e}ronique and Riffault, Sabine and Lambrecht, Bart and Langella, Philippe and Hammad, Hamida and Thomas, Muriel},
  issn         = {1751-7362},
  journal      = {ISME JOURNAL},
  keyword      = {GUT MICROBIOTA,COLONIC EPITHELIUM,ALLERGIC DISEASES,AIRWAY MICROBIOME,DENDRITIC CELLS,IMMUNE-SYSTEM,EARLY-LIFE,RESPONSES,COLONIZATION,INFLAMMATION},
  language     = {eng},
  number       = {5},
  pages        = {1061--1074},
  title        = {Bacteria isolated from lung modulate asthma susceptibility in mice},
  url          = {http://dx.doi.org/10.1038/ismej.2016.181},
  volume       = {11},
  year         = {2017},
}

Chicago
Remot, Aude, Delphyne Descamps, Marie-Louise Noordine, Abdelhak Boukadiri, Elliot Mathieu, Véronique Robert, Sabine Riffault, et al. 2017. “Bacteria Isolated from Lung Modulate Asthma Susceptibility in Mice.” Isme Journal 11 (5): 1061–1074.
APA
Remot, A., Descamps, D., Noordine, M.-L., Boukadiri, A., Mathieu, E., Robert, V., Riffault, S., et al. (2017). Bacteria isolated from lung modulate asthma susceptibility in mice. ISME JOURNAL, 11(5), 1061–1074.
Vancouver
1.
Remot A, Descamps D, Noordine M-L, Boukadiri A, Mathieu E, Robert V, et al. Bacteria isolated from lung modulate asthma susceptibility in mice. ISME JOURNAL. 2017;11(5):1061–74.
MLA
Remot, Aude, Delphyne Descamps, Marie-Louise Noordine, et al. “Bacteria Isolated from Lung Modulate Asthma Susceptibility in Mice.” ISME JOURNAL 11.5 (2017): 1061–1074. Print.