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Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10

Hamida Hammad (UGent) , Matthias Vanderkerken (UGent) , Philippe Pouliot (UGent) , Kim Deswarte (UGent) , Wendy Toussaint (UGent) , Karl Vergote (UGent) , Lana Vandersarren (UGent) , Sophie Janssens (UGent) , Ioanna Ramou (UGent) , Savvas Savvides (UGent) , et al.
(2017) NATURE IMMUNOLOGY. 18(3). p.313-320
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Abstract
Notch2 and B cell antigen receptor (BCR) signaling determine whether transitional B cells become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown how these pathways are related. We generated Taok3−/− mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects in the development of MZB but not FoB cells. Type 1 transitional (T1) B cells required Taok3 to rapidly respond to ligation by the Notch ligand Delta-like 1. BCR ligation by endogenous or exogenous ligands induced the surface expression of the metalloproteinase ADAM10 on T1 B cells in a Taok3-dependent manner. T1 B cells expressing surface ADAM10 were committed to becoming MZB cells in vivo, whereas T1 B cells lacking expression of ADAM10 were not. Thus, during positive selection in the spleen, BCR signaling causes immature T1 B cells to become receptive to Notch ligands via Taok3-mediated surface expression of ADAM10.
Keywords
POSITIVE SELECTION, IMMUNE-RESPONSES, B1B CELLS, IN-VIVO, NOTCH2, MATURE, MICE, DELTA-LIKE-1, DIMERIZATION, LYMPHOCYTES

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MLA
Hammad, Hamida et al. “Transitional B Cells Commit to Marginal Zone B Cell Fate by Taok3-mediated Surface Expression of ADAM10.” NATURE IMMUNOLOGY 18.3 (2017): 313–320. Print.
APA
Hammad, H., Vanderkerken, M., Pouliot, P., Deswarte, K., Toussaint, W., Vergote, K., Vandersarren, L., et al. (2017). Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10. NATURE IMMUNOLOGY, 18(3), 313–320.
Chicago author-date
Hammad, Hamida, Matthias Vanderkerken, Philippe Pouliot, Kim Deswarte, Wendy Toussaint, Karl Vergote, Lana Vandersarren, et al. 2017. “Transitional B Cells Commit to Marginal Zone B Cell Fate by Taok3-mediated Surface Expression of ADAM10.” Nature Immunology 18 (3): 313–320.
Chicago author-date (all authors)
Hammad, Hamida, Matthias Vanderkerken, Philippe Pouliot, Kim Deswarte, Wendy Toussaint, Karl Vergote, Lana Vandersarren, Sophie Janssens, Ioanna Ramou, Savvas Savvides, Jody Haigh, Rudi Hendriks, Manfred Kopf, Katleen Craessaerts, Bart de Strooper, John F Kearney, Daniel H Conrad, and Bart Lambrecht. 2017. “Transitional B Cells Commit to Marginal Zone B Cell Fate by Taok3-mediated Surface Expression of ADAM10.” Nature Immunology 18 (3): 313–320.
Vancouver
1.
Hammad H, Vanderkerken M, Pouliot P, Deswarte K, Toussaint W, Vergote K, et al. Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10. NATURE IMMUNOLOGY. 2017;18(3):313–20.
IEEE
[1]
H. Hammad et al., “Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10,” NATURE IMMUNOLOGY, vol. 18, no. 3, pp. 313–320, 2017.
@article{8511468,
  abstract     = {Notch2 and B cell antigen receptor (BCR) signaling determine whether transitional B cells become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown how these pathways are related. We generated Taok3−/− mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects in the development of MZB but not FoB cells. Type 1 transitional (T1) B cells required Taok3 to rapidly respond to ligation by the Notch ligand Delta-like 1. BCR ligation by endogenous or exogenous ligands induced the surface expression of the metalloproteinase ADAM10 on T1 B cells in a Taok3-dependent manner. T1 B cells expressing surface ADAM10 were committed to becoming MZB cells in vivo, whereas T1 B cells lacking expression of ADAM10 were not. Thus, during positive selection in the spleen, BCR signaling causes immature T1 B cells to become receptive to Notch ligands via Taok3-mediated surface expression of ADAM10.},
  author       = {Hammad, Hamida and Vanderkerken, Matthias and Pouliot, Philippe and Deswarte, Kim and Toussaint, Wendy and Vergote, Karl and Vandersarren, Lana and Janssens, Sophie and Ramou, Ioanna and Savvides, Savvas and Haigh, Jody and Hendriks, Rudi and Kopf, Manfred and Craessaerts, Katleen and de Strooper, Bart and Kearney, John F and Conrad, Daniel H and Lambrecht, Bart},
  issn         = {1529-2908},
  journal      = {NATURE IMMUNOLOGY},
  keywords     = {POSITIVE SELECTION,IMMUNE-RESPONSES,B1B CELLS,IN-VIVO,NOTCH2,MATURE,MICE,DELTA-LIKE-1,DIMERIZATION,LYMPHOCYTES},
  language     = {eng},
  number       = {3},
  pages        = {313--320},
  title        = {Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10},
  url          = {http://dx.doi.org/10.1038/ni.3657},
  volume       = {18},
  year         = {2017},
}

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