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Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10

Hamida Hammad UGent, Matthias Vanderkerken UGent, Philippe Pouliot UGent, Kim Deswarte UGent, Wendy Toussaint UGent, Karl Vergote UGent, Lana Vandersarren UGent, Sophie Janssens UGent, Ioanna Ramou, Savvas Savvides UGent, et al. (2017) NATURE IMMUNOLOGY. 18(3). p.313-320
abstract
Notch2 and B cell antigen receptor (BCR) signaling determine whether transitional B cells become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown how these pathways are related. We generated Taok3−/− mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects in the development of MZB but not FoB cells. Type 1 transitional (T1) B cells required Taok3 to rapidly respond to ligation by the Notch ligand Delta-like 1. BCR ligation by endogenous or exogenous ligands induced the surface expression of the metalloproteinase ADAM10 on T1 B cells in a Taok3-dependent manner. T1 B cells expressing surface ADAM10 were committed to becoming MZB cells in vivo, whereas T1 B cells lacking expression of ADAM10 were not. Thus, during positive selection in the spleen, BCR signaling causes immature T1 B cells to become receptive to Notch ligands via Taok3-mediated surface expression of ADAM10.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
POSITIVE SELECTION, IMMUNE-RESPONSES, B1B CELLS, IN-VIVO, NOTCH2, MATURE, MICE, DELTA-LIKE-1, DIMERIZATION, LYMPHOCYTES
journal title
NATURE IMMUNOLOGY
Nat. Immunol.
volume
18
issue
3
pages
313 - 320
Web of Science type
Article
Web of Science id
000394413400011
ISSN
1529-2908
DOI
10.1038/ni.3657
language
English
UGent publication?
yes
classification
A1
additional info
the first three authors contributed equally to this work
copyright statement
I have transferred the copyright for this publication to the publisher
id
8511468
handle
http://hdl.handle.net/1854/LU-8511468
date created
2017-02-27 12:36:46
date last changed
2017-04-03 11:26:15
@article{8511468,
  abstract     = {Notch2 and B cell antigen receptor (BCR) signaling determine whether transitional B cells become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown how these pathways are related. We generated Taok3\ensuremath{-}/\ensuremath{-} mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects in the development of MZB but not FoB cells. Type 1 transitional (T1) B cells required Taok3 to rapidly respond to ligation by the Notch ligand Delta-like 1. BCR ligation by endogenous or exogenous ligands induced the surface expression of the metalloproteinase ADAM10 on T1 B cells in a Taok3-dependent manner. T1 B cells expressing surface ADAM10 were committed to becoming MZB cells in vivo, whereas T1 B cells lacking expression of ADAM10 were not. Thus, during positive selection in the spleen, BCR signaling causes immature T1 B cells to become receptive to Notch ligands via Taok3-mediated surface expression of ADAM10.},
  author       = {Hammad, Hamida and Vanderkerken, Matthias and Pouliot, Philippe and Deswarte, Kim and Toussaint, Wendy and Vergote, Karl and Vandersarren, Lana and Janssens, Sophie and Ramou, Ioanna and Savvides, Savvas and Haigh, Jody and Hendriks, Rudi and Kopf, Manfred and Craessaerts, Katleen and de Strooper, Bart and Kearney, John F and Conrad, Daniel H and Lambrecht, Bart},
  issn         = {1529-2908},
  journal      = {NATURE IMMUNOLOGY},
  keyword      = {POSITIVE SELECTION,IMMUNE-RESPONSES,B1B CELLS,IN-VIVO,NOTCH2,MATURE,MICE,DELTA-LIKE-1,DIMERIZATION,LYMPHOCYTES},
  language     = {eng},
  number       = {3},
  pages        = {313--320},
  title        = {Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10},
  url          = {http://dx.doi.org/10.1038/ni.3657},
  volume       = {18},
  year         = {2017},
}

Chicago
Hammad, Hamida, Matthias Vanderkerken, Philippe Pouliot, Kim Deswarte, Wendy Toussaint, Karl Vergote, Lana Vandersarren, et al. 2017. “Transitional B Cells Commit to Marginal Zone B Cell Fate by Taok3-mediated Surface Expression of ADAM10.” Nature Immunology 18 (3): 313–320.
APA
Hammad, H., Vanderkerken, M., Pouliot, P., Deswarte, K., Toussaint, W., Vergote, K., Vandersarren, L., et al. (2017). Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10. NATURE IMMUNOLOGY, 18(3), 313–320.
Vancouver
1.
Hammad H, Vanderkerken M, Pouliot P, Deswarte K, Toussaint W, Vergote K, et al. Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10. NATURE IMMUNOLOGY. 2017;18(3):313–20.
MLA
Hammad, Hamida, Matthias Vanderkerken, Philippe Pouliot, et al. “Transitional B Cells Commit to Marginal Zone B Cell Fate by Taok3-mediated Surface Expression of ADAM10.” NATURE IMMUNOLOGY 18.3 (2017): 313–320. Print.