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Myeloid cells in asthma

Bart Lambrecht (UGent) , Emma Persson (UGent) and Hamida Hammad (UGent)
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Abstract
Asthma is a heterogeneous chronic inflammatory disorder of the airways, and not surprisingly, many myeloid cells play a crucial role in pathogenesis. Antigen-presenting dendritic cells are the first to recognize the allergens, pollutants, and viruses that are implicated in asthma pathogenesis, and subsequently initiate the adaptive immune response by migrating to lymph nodes. Eosinophils are the hallmark of type 2 inflammation, releasing toxic compounds in the airways and contributing to airway remodeling. Mast cells and basophils control both the early- and late-phase allergic response and contribute to alterations in smooth muscle reactivity. Finally, relatively little is known about neutrophils and macrophages in this disease. Although many of these myeloid cells respond well to treatment with inhaled steroids, there is now an increasing armamentarium of targeted biologicals that can specifically eliminate only one myeloid cell population, like eosinophils. It is only with those new tools that we will be able to fully understand the role of myeloid cells in chronic asthma in humans.
Keywords
ALLERGIC AIRWAY INFLAMMATION, HOUSE-DUST MITE, ALTERNATIVELY ACTIVATED MACROPHAGES, PLASMACYTOID DENDRITIC CELLS, ANTIGEN-PRESENTING CELLS, MAJOR BASIC-PROTEIN, HUMAN MAST-CELLS, RESIDENT ALVEOLAR MACROPHAGES, COLONY-STIMULATING FACTOR, EXTRACELLULAR DNA TRAPS

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Citation

Please use this url to cite or link to this publication:

MLA
Lambrecht, Bart, Emma Persson, and Hamida Hammad. “Myeloid Cells in Asthma.” Ed. Siamon Gordon. MICROBIOLOGY SPECTRUM 5.1 (2017): n. pag. Print.
APA
Lambrecht, B., Persson, E., & Hammad, H. (2017). Myeloid cells in asthma. (S. Gordon, Ed.)MICROBIOLOGY SPECTRUM, 5(1).
Chicago author-date
Lambrecht, Bart, Emma Persson, and Hamida Hammad. 2017. “Myeloid Cells in Asthma.” Ed. Siamon Gordon. Microbiology Spectrum 5 (1).
Chicago author-date (all authors)
Lambrecht, Bart, Emma Persson, and Hamida Hammad. 2017. “Myeloid Cells in Asthma.” Ed. Siamon Gordon. Microbiology Spectrum 5 (1).
Vancouver
1.
Lambrecht B, Persson E, Hammad H. Myeloid cells in asthma. Gordon S, editor. MICROBIOLOGY SPECTRUM. 2017;5(1).
IEEE
[1]
B. Lambrecht, E. Persson, and H. Hammad, “Myeloid cells in asthma,” MICROBIOLOGY SPECTRUM, vol. 5, no. 1, 2017.
@article{8511463,
  abstract     = {Asthma is a heterogeneous chronic inflammatory disorder of the airways, and not surprisingly, many myeloid cells play a crucial role in pathogenesis. Antigen-presenting dendritic cells are the first to recognize the allergens, pollutants, and viruses that are implicated in asthma pathogenesis, and subsequently initiate the adaptive immune response by migrating to lymph nodes. Eosinophils are the hallmark of type 2 inflammation, releasing toxic compounds in the airways and contributing to airway remodeling. Mast cells and basophils control both the early- and late-phase allergic response and contribute to alterations in smooth muscle reactivity. Finally, relatively little is known about neutrophils and macrophages in this disease. Although many of these myeloid cells respond well to treatment with inhaled steroids, there is now an increasing armamentarium of targeted biologicals that can specifically eliminate only one myeloid cell population, like eosinophils. It is only with those new tools that we will be able to fully understand the role of myeloid cells in chronic asthma in humans.},
  articleno    = {MCHD-0053-2016},
  author       = {Lambrecht, Bart and Persson, Emma and Hammad, Hamida},
  editor       = {Gordon, Siamon},
  issn         = {2165-0497},
  journal      = {MICROBIOLOGY SPECTRUM},
  keywords     = {ALLERGIC AIRWAY INFLAMMATION,HOUSE-DUST MITE,ALTERNATIVELY ACTIVATED MACROPHAGES,PLASMACYTOID DENDRITIC CELLS,ANTIGEN-PRESENTING CELLS,MAJOR BASIC-PROTEIN,HUMAN MAST-CELLS,RESIDENT ALVEOLAR MACROPHAGES,COLONY-STIMULATING FACTOR,EXTRACELLULAR DNA TRAPS},
  language     = {eng},
  number       = {1},
  pages        = {17},
  title        = {Myeloid cells in asthma},
  url          = {http://dx.doi.org/10.1128/microbiolspec.mchd-0053-2016},
  volume       = {5},
  year         = {2017},
}

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