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Mechanisms of the Development of Allergy (MeDALL) : introducing novel concepts in allergy phenotypes

Josep M Anto, Jean Bousquet, Mubeccel Akdis, Charles Auffray, Thomas Keil, Isabelle Momas, Dirkje S Postma, Rudolf Valenta, Magnus Wickman, Anne Cambon-Thomsen, et al. (2017) JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 139(2). p.388-399
abstract
Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non–IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years. Thirteen thousand children were prospectively followed after puberty by using a newly standardized MeDALL Core Questionnaire. A microarray developed for allergen molecules with increased IgE sensitivity was obtained for 3,292 children. Estimates of air pollution exposure from previous studies were available for 10,000 children. Omics data included those from historical genome-wide association studies (23,000 children) and DNA methylation (2,173), targeted multiplex biomarker (1,427), and transcriptomic (723) studies. Using classical epidemiology and machine-learning methods in 16,147 children aged 4 years and 11,080 children aged 8 years, MeDALL showed the multimorbidity of eczema, rhinitis, and asthma and estimated that only 38% of multimorbidity was attributable to IgE sensitization. MeDALL has proposed a new vision of multimorbidity independent of IgE sensitization, and has shown that monosensitization and polysensitization represent 2 distinct phenotypes. The translational component of MeDALL is shown by the identification of a novel allergic phenotype characterized by polysensitization and multimorbidity, which is associated with the frequency, persistence, and severity of allergic symptoms. The results of MeDALL will help integrate personalized, predictive, preventative, and participatory approaches in allergic diseases.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
J. Allergy Clin. Immunol.
volume
139
issue
2
pages
388 - 399
Web of Science type
Article
Web of Science id
000397002400002
ISSN
0091-6749
DOI
10.1016/j.jaci.2016.12.940
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors contributed equally to this work
copyright statement
I have transferred the copyright for this publication to the publisher
id
8511455
handle
http://hdl.handle.net/1854/LU-8511455
date created
2017-02-27 11:22:40
date last changed
2017-06-27 12:50:01
@article{8511455,
  abstract     = {Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non--IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years. Thirteen thousand children were prospectively followed after puberty by using a newly standardized MeDALL Core Questionnaire. A microarray developed for allergen molecules with increased IgE sensitivity was obtained for 3,292 children. Estimates of air pollution exposure from previous studies were available for 10,000 children. Omics data included those from historical genome-wide association studies (23,000 children) and DNA methylation (2,173), targeted multiplex biomarker (1,427), and transcriptomic (723) studies. Using classical epidemiology and machine-learning methods in 16,147 children aged 4 years and 11,080 children aged 8 years, MeDALL showed the multimorbidity of eczema, rhinitis, and asthma and estimated that only 38\% of multimorbidity was attributable to IgE sensitization. MeDALL has proposed a new vision of multimorbidity independent of IgE sensitization, and has shown that monosensitization and polysensitization represent 2 distinct phenotypes. The translational component of MeDALL is shown by the identification of a novel allergic phenotype characterized by polysensitization and multimorbidity, which is associated with the frequency, persistence, and severity of allergic symptoms. The results of MeDALL will help integrate personalized, predictive, preventative, and participatory approaches in allergic diseases.},
  author       = {Anto, Josep M and Bousquet, Jean and Akdis, Mubeccel and Auffray, Charles and Keil, Thomas and Momas, Isabelle and Postma, Dirkje S and Valenta, Rudolf and Wickman, Magnus and Cambon-Thomsen, Anne and Haahtela, Tari and Lambrecht, Bart and Lodrup Carlsen, Karin C and Koppelman, Gerard H and Sunyer, Jordi and Zuberbier, Torsten and Annesi-Maesano, Isabelle and Arno, Albert and Bindslev-Jensen, Carsten and De Carlo, Giuseppe and Forastiere, Francesco and Heinrich, Joachim and Kowalski, Marek L and Maier, Dieter and Mel{\'e}n, Erik and Smit, Henriette A and Standl, Marie and Wright, John and Asarnoj, Anna and Benet, Marta and Ballardini, Natalia and Garcia-Aymerich, Judith and Gehring, Ulrike and Guerra, Stefano and Hohmann, Cynthia and Kull, Inger and Lupinek, Christian and Pinart, Mariona and Skrindo, Ingebjorg and Westman, Marit and Smagghe, Delphine and Akdis, Cezmi and Andersson, Niklas and Bachert, Claus and Ballereau, Stephane and Ballester, Ferran and Basagana, Xavier and Bedbrook, Anna and Bergstrom, Anna and von Berg, Andrea and Brunekreef, Bert and Burte, Emilie and Carlsen, Kai-Hakon and Chatzi, Leda and Coquet, Jonathan M and Curin, Mirela and Demoly, Pascal and Eller, Esben and Fantini, Maria Pia and von Hertzen, Leena and Hovland, Vergard and Jacquemin, Benedicte and Just, Jocelyne and Keller, Theresa and Kiss, Renata and Kogevinas, Manolis and Koletzko, Sibylle and Lau, Susanne and Lehmann, Irina and Lemonnier, Nicolas and M{\"a}kel{\"a}, Mika and Mestres, Jordi and Mowinckel, Peter and Nadif, Rachel and Nawijn, Martijn C and Pellet, Johan and Pin, Isabelle and Porta, Daniela and Ranci{\`e}re, Fanny and Rial-Sebbag, Emmanuelle and Saeys, Yvan and Schuijs, Martijn J and Siroux, Valerie and Tischer, Christina G and Torrent, Mathies and Varraso, Raphaelle and Wenzel, Kalus and Xu, Cheng-Jian},
  issn         = {0091-6749},
  journal      = {JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY},
  language     = {eng},
  number       = {2},
  pages        = {388--399},
  title        = {Mechanisms of the Development of Allergy (MeDALL) : introducing novel concepts in allergy phenotypes},
  url          = {http://dx.doi.org/10.1016/j.jaci.2016.12.940},
  volume       = {139},
  year         = {2017},
}

Chicago
Anto, Josep M, Jean Bousquet, Mubeccel Akdis, Charles Auffray, Thomas Keil, Isabelle Momas, Dirkje S Postma, et al. 2017. “Mechanisms of the Development of Allergy (MeDALL) : Introducing Novel Concepts in Allergy Phenotypes.” Journal of Allergy and Clinical Immunology 139 (2): 388–399.
APA
Anto, J. M., Bousquet, J., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., et al. (2017). Mechanisms of the Development of Allergy (MeDALL) : introducing novel concepts in allergy phenotypes. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(2), 388–399.
Vancouver
1.
Anto JM, Bousquet J, Akdis M, Auffray C, Keil T, Momas I, et al. Mechanisms of the Development of Allergy (MeDALL) : introducing novel concepts in allergy phenotypes. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(2):388–99.
MLA
Anto, Josep M, Jean Bousquet, Mubeccel Akdis, et al. “Mechanisms of the Development of Allergy (MeDALL) : Introducing Novel Concepts in Allergy Phenotypes.” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 139.2 (2017): 388–399. Print.