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Facing coagulation disorders after acute trauma

F Mullier, S Lessire, J-C de Schoutheete, B Chatelain, V Deneys, V Mathieux, S Hachimi Idrissi, J-M Dogne, Jean-Baptiste Watelet UGent, M Gourdin, et al. (2016) B-ENT. 12(suppl. 26). p.67-85
abstract
Problems/objectives: Trauma is the leading cause of mortality for persons between one and 44 years of age, essentially due to bleeding complications. Methodology: We screened the PubMed, Scopus and Cochrane Library databases, using specific keywords. Only publications in English were considered. Main results: The pathophysiology of trauma-induced coagulopathy (TIC) is complex and includes the classic "lethal triad" (i.e., haemodilution, acidosis, hypothermia) but may also include activation of protein C, endothelial and platelet dysfunction, and fibrinogen depletion. The time between trauma and treatment of the resultant massive bleeding should be as short as possible using techniques for rapid control of bleeding and avoiding aggravating factors (hypothermia, metabolic acidosis and hypocalcaemia). If given within three hours of injury, tranexamic acid (TXA) reduces all causes of mortality in trauma patients and reduces transfusion requirements. In a bleeding patient, crystalloids are preferred to colloids and the ratio of fresh frozen plasma to packed red blood cells should be at least 1:2. Damage control surgery (DCS) should be considered for patients who present with, or are at risk for developing, the "lethal triad", multiple life-threatening injuries or shock, and in mass casualty situations. DCS can also aid in the evaluation of the extent of tissue injuries and the control of haemorrhage and infection. Finally, there is currently no evidence of the added value of laboratory assays in the management of TIC. Conclusions: TIC appears quickly after trauma and should be anticipated and detected as soon as possible. TXA plays a central role in the management of such patients. Each institution should establish a local algorithm for the management of bleeding patients.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Trauma, coagulopathy, tranexamic acid, mechanisms, treatment, DAMAGE-CONTROL RESUSCITATION, EXTRACORPOREAL MEMBRANE-OXYGENATION, ENDOTHELIAL GLYCOCALYX DEGRADATION, PLACEBO-CONTROLLED TRIAL, MASSIVE-TRANSFUSION, CONTROL SURGERY, BRAIN-INJURY, MAJOR TRAUMA, TRANEXAMIC ACID, PLATELET-FUNCTION
journal title
B-ENT
B-ENT
volume
12
issue
suppl. 26
pages
67 - 85
Web of Science type
Article
Web of Science id
000391156400009
JCR category
OTORHINOLARYNGOLOGY
JCR impact factor
0.578 (2016)
JCR rank
40/42 (2016)
JCR quartile
4 (2016)
ISSN
0001-6497
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8511032
handle
http://hdl.handle.net/1854/LU-8511032
date created
2017-02-23 14:57:00
date last changed
2017-05-17 12:49:43
@article{8511032,
  abstract     = {Problems/objectives: Trauma is the leading cause of mortality for persons between one and 44 years of age, essentially due to bleeding complications. 
Methodology: We screened the PubMed, Scopus and Cochrane Library databases, using specific keywords. Only publications in English were considered. 
Main results: The pathophysiology of trauma-induced coagulopathy (TIC) is complex and includes the classic {\textacutedbl}lethal triad{\textacutedbl} (i.e., haemodilution, acidosis, hypothermia) but may also include activation of protein C, endothelial and platelet dysfunction, and fibrinogen depletion. 
The time between trauma and treatment of the resultant massive bleeding should be as short as possible using techniques for rapid control of bleeding and avoiding aggravating factors (hypothermia, metabolic acidosis and hypocalcaemia). If given within three hours of injury, tranexamic acid (TXA) reduces all causes of mortality in trauma patients and reduces transfusion requirements. In a bleeding patient, crystalloids are preferred to colloids and the ratio of fresh frozen plasma to packed red blood cells should be at least 1:2. Damage control surgery (DCS) should be considered for patients who present with, or are at risk for developing, the {\textacutedbl}lethal triad{\textacutedbl}, multiple life-threatening injuries or shock, and in mass casualty situations. DCS can also aid in the evaluation of the extent of tissue injuries and the control of haemorrhage and infection. Finally, there is currently no evidence of the added value of laboratory assays in the management of TIC. 
Conclusions: TIC appears quickly after trauma and should be anticipated and detected as soon as possible. TXA plays a central role in the management of such patients. Each institution should establish a local algorithm for the management of bleeding patients.},
  author       = {Mullier, F and Lessire, S and de Schoutheete, J-C and Chatelain, B and Deneys, V and Mathieux, V and Hachimi Idrissi, S and Dogne, J-M and Watelet, Jean-Baptiste and Gourdin, M and Dincq, A-S},
  issn         = {0001-6497},
  journal      = {B-ENT},
  keyword      = {Trauma,coagulopathy,tranexamic acid,mechanisms,treatment,DAMAGE-CONTROL RESUSCITATION,EXTRACORPOREAL MEMBRANE-OXYGENATION,ENDOTHELIAL GLYCOCALYX DEGRADATION,PLACEBO-CONTROLLED TRIAL,MASSIVE-TRANSFUSION,CONTROL SURGERY,BRAIN-INJURY,MAJOR TRAUMA,TRANEXAMIC ACID,PLATELET-FUNCTION},
  language     = {eng},
  number       = {suppl. 26},
  pages        = {67--85},
  title        = {Facing coagulation disorders after acute trauma},
  volume       = {12},
  year         = {2016},
}

Chicago
Mullier, F, S Lessire, J-C de Schoutheete, B Chatelain, V Deneys, V Mathieux, S Hachimi Idrissi, et al. 2016. “Facing Coagulation Disorders After Acute Trauma.” B-ent 12 (suppl. 26): 67–85.
APA
Mullier, F., Lessire, S., de Schoutheete, J.-C., Chatelain, B., Deneys, V., Mathieux, V., Hachimi Idrissi, S., et al. (2016). Facing coagulation disorders after acute trauma. B-ENT, 12(suppl. 26), 67–85.
Vancouver
1.
Mullier F, Lessire S, de Schoutheete J-C, Chatelain B, Deneys V, Mathieux V, et al. Facing coagulation disorders after acute trauma. B-ENT. 2016;12(suppl. 26):67–85.
MLA
Mullier, F, S Lessire, J-C de Schoutheete, et al. “Facing Coagulation Disorders After Acute Trauma.” B-ENT 12.suppl. 26 (2016): 67–85. Print.