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High prevalence of IgG antibodies to Ebola virus in the Efe pygmy population in the Watsa region, Democratic Republic of the Congo

Sabue Mulangu, Matthias Borchert, Janusz Paweska, Antoine Tshomba, Afongenda Afounde, Amayo Kulidri, Robert Swanepoel, Jean-Jacques Muyembe-Tamfum and Patrick Van Der Stuyft UGent (2016) BMC INFECTIOUS DISEASES. 16.
abstract
Background: Factors related to the natural transmission of Ebola virus (EBOV) to humans are still not well defined. Results of previous sero-prevalence studies suggest that circulation of EBOV in human population is common in sub-Saharan Africa. The Efe pygmies living in Democratic Republic of the Congo are known to be exposed to potential risk factors of EBOV infection such as bush meat hunting, entry into caves, and contact with bats. We studied the pygmy population of Watsa region to determine seroprevalence to EBOV infection and possible risks factors. Method: Volunteer participants (N = 300) aged 10 years or above were interviewed about behavior that may constitute risk factors for transmission of EBOV, including exposures to rats, bats, monkeys and entry into caves. Samples of venous blood were collected and tested for IgG antibody against EBOV by enzyme-linked immunosorbent assay (ELISA). The chi(2)-test and Fisher's exact test were used for the comparison of proportions and the Student's t-test to compare means. The association between age group and anti-EBOV IgG prevalence was analysed by a nonparametric test for trend. Results: The prevalence of anti-EBOV IgG was 18.7 % overall and increased significantly with age (p = 0.023). No association was observed with exposure to risk factors (contacts with rats, bats, monkeys, or entry into caves). Conclusions: The seroprevalence of IgG antibody to EBOV in pygmies in Watsa region is among the highest ever reported, but it remains unclear which exposures might lead to this high infection rate calling for further ecological and behavioural studies.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MARBURG HEMORRHAGIC-FEVER, SEROLOGICAL SURVEY, RISK-FACTORS, LIBERIA, AFRICA, FOREST, OGOOUE, GABON, ZAIRE, Ebola virus, IgG Antibody, Pygmy
journal title
BMC INFECTIOUS DISEASES
BMC Infect. Dis.
volume
16
article number
263
pages
6 pages
Web of Science type
Article
Web of Science id
000377946900001
JCR category
INFECTIOUS DISEASES
JCR impact factor
2.768 (2016)
JCR rank
37/84 (2016)
JCR quartile
2 (2016)
ISSN
1471-2334
DOI
10.1186/s12879-016-1607-y
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8510991
handle
http://hdl.handle.net/1854/LU-8510991
date created
2017-02-23 14:21:04
date last changed
2017-03-08 13:08:47
@article{8510991,
  abstract     = {Background: Factors related to the natural transmission of Ebola virus (EBOV) to humans are still not well defined. Results of previous sero-prevalence studies suggest that circulation of EBOV in human population is common in sub-Saharan Africa. The Efe pygmies living in Democratic Republic of the Congo are known to be exposed to potential risk factors of EBOV infection such as bush meat hunting, entry into caves, and contact with bats. We studied the pygmy population of Watsa region to determine seroprevalence to EBOV infection and possible risks factors. 
Method: Volunteer participants (N = 300) aged 10 years or above were interviewed about behavior that may constitute risk factors for transmission of EBOV, including exposures to rats, bats, monkeys and entry into caves. Samples of venous blood were collected and tested for IgG antibody against EBOV by enzyme-linked immunosorbent assay (ELISA). The chi(2)-test and Fisher's exact test were used for the comparison of proportions and the Student's t-test to compare means. The association between age group and anti-EBOV IgG prevalence was analysed by a nonparametric test for trend. 
Results: The prevalence of anti-EBOV IgG was 18.7 \% overall and increased significantly with age (p = 0.023). No association was observed with exposure to risk factors (contacts with rats, bats, monkeys, or entry into caves). 
Conclusions: The seroprevalence of IgG antibody to EBOV in pygmies in Watsa region is among the highest ever reported, but it remains unclear which exposures might lead to this high infection rate calling for further ecological and behavioural studies.},
  articleno    = {263},
  author       = {Mulangu, Sabue and Borchert, Matthias and Paweska, Janusz and Tshomba, Antoine and Afounde, Afongenda and Kulidri, Amayo and Swanepoel, Robert and Muyembe-Tamfum, Jean-Jacques and Van Der Stuyft, Patrick},
  issn         = {1471-2334},
  journal      = {BMC INFECTIOUS DISEASES},
  keyword      = {MARBURG HEMORRHAGIC-FEVER,SEROLOGICAL SURVEY,RISK-FACTORS,LIBERIA,AFRICA,FOREST,OGOOUE,GABON,ZAIRE,Ebola virus,IgG Antibody,Pygmy},
  language     = {eng},
  pages        = {6},
  title        = {High prevalence of IgG antibodies to Ebola virus in the Efe pygmy population in the Watsa region, Democratic Republic of the Congo},
  url          = {http://dx.doi.org/10.1186/s12879-016-1607-y},
  volume       = {16},
  year         = {2016},
}

Chicago
Mulangu, Sabue, Matthias Borchert, Janusz Paweska, Antoine Tshomba, Afongenda Afounde, Amayo Kulidri, Robert Swanepoel, Jean-Jacques Muyembe-Tamfum, and Patrick Van Der Stuyft. 2016. “High Prevalence of IgG Antibodies to Ebola Virus in the Efe Pygmy Population in the Watsa Region, Democratic Republic of the Congo.” Bmc Infectious Diseases 16.
APA
Mulangu, S., Borchert, M., Paweska, J., Tshomba, A., Afounde, A., Kulidri, A., Swanepoel, R., et al. (2016). High prevalence of IgG antibodies to Ebola virus in the Efe pygmy population in the Watsa region, Democratic Republic of the Congo. BMC INFECTIOUS DISEASES, 16.
Vancouver
1.
Mulangu S, Borchert M, Paweska J, Tshomba A, Afounde A, Kulidri A, et al. High prevalence of IgG antibodies to Ebola virus in the Efe pygmy population in the Watsa region, Democratic Republic of the Congo. BMC INFECTIOUS DISEASES. 2016;16.
MLA
Mulangu, Sabue, Matthias Borchert, Janusz Paweska, et al. “High Prevalence of IgG Antibodies to Ebola Virus in the Efe Pygmy Population in the Watsa Region, Democratic Republic of the Congo.” BMC INFECTIOUS DISEASES 16 (2016): n. pag. Print.