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Non-compaction cardiomyopathy : a genetically and clinically heterogeneous disorder : presentation of two cases and review of the literature

(2015) ACTA CARDIOLOGICA. 70(6). p.625-631
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Organization
Abstract
Left ventricular non-compaction (LVNC) is a rare disease that can occur isolated or in association with other disorders, including congenital heart disease and musculoskeletal disorders. It is characterized by a two-layered myocardium with excessive trabeculation of the left ventricle. Diagnosis is challenging as left ventricular trabeculations can be pathological yet can also be a normal finding in athletes and black people, leading to overdiagnosis. Echocardiography and CMR are important diagnostic tools. LVNC is often complicated by ventricular dysfunction, arrhythmias and thromboembolic events. Based on two cases, we review the pathogenesis, genetic background, clinical features and treatment of LVNC according to the available guidelines.
Keywords
VENTRICULAR NON-COMPACTION, NONCOMPACTION CARDIOMYOPATHY, DISTINCT, CARDIOMYOPATHY, DIAGNOSTIC-CRITERIA, DELETION 1P36, FOLLOW-UP, MUTATIONS, HYPERTRABECULATION/NONCOMPACTION, MYOCARDIUM, TRABECULATION, Left ventricular non-compaction, heart failure, echocardiography, cardiomyopathy, genetics

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Citation

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MLA
Rooms, Isabel, Karl Dujardin, and Johan De Sutter. “Non-compaction Cardiomyopathy : a Genetically and Clinically Heterogeneous Disorder : Presentation of Two Cases and Review of the Literature.” ACTA CARDIOLOGICA 70.6 (2015): 625–631. Print.
APA
Rooms, I., Dujardin, K., & De Sutter, J. (2015). Non-compaction cardiomyopathy : a genetically and clinically heterogeneous disorder : presentation of two cases and review of the literature. ACTA CARDIOLOGICA, 70(6), 625–631.
Chicago author-date
Rooms, Isabel, Karl Dujardin, and Johan De Sutter. 2015. “Non-compaction Cardiomyopathy : a Genetically and Clinically Heterogeneous Disorder : Presentation of Two Cases and Review of the Literature.” Acta Cardiologica 70 (6): 625–631.
Chicago author-date (all authors)
Rooms, Isabel, Karl Dujardin, and Johan De Sutter. 2015. “Non-compaction Cardiomyopathy : a Genetically and Clinically Heterogeneous Disorder : Presentation of Two Cases and Review of the Literature.” Acta Cardiologica 70 (6): 625–631.
Vancouver
1.
Rooms I, Dujardin K, De Sutter J. Non-compaction cardiomyopathy : a genetically and clinically heterogeneous disorder : presentation of two cases and review of the literature. ACTA CARDIOLOGICA. 2015;70(6):625–31.
IEEE
[1]
I. Rooms, K. Dujardin, and J. De Sutter, “Non-compaction cardiomyopathy : a genetically and clinically heterogeneous disorder : presentation of two cases and review of the literature,” ACTA CARDIOLOGICA, vol. 70, no. 6, pp. 625–631, 2015.
@article{8510955,
  abstract     = {Left ventricular non-compaction (LVNC) is a rare disease that can occur isolated or in association with other disorders, including congenital heart disease and musculoskeletal disorders. It is characterized by a two-layered myocardium with excessive trabeculation of the left ventricle. Diagnosis is challenging as left ventricular trabeculations can be pathological yet can also be a normal finding in athletes and black people, leading to overdiagnosis. Echocardiography and CMR are important diagnostic tools. LVNC is often complicated by ventricular dysfunction, arrhythmias and thromboembolic events. Based on two cases, we review the pathogenesis, genetic background, clinical features and treatment of LVNC according to the available guidelines.},
  author       = {Rooms, Isabel and Dujardin, Karl and De Sutter, Johan},
  issn         = {0001-5385},
  journal      = {ACTA CARDIOLOGICA},
  keywords     = {VENTRICULAR NON-COMPACTION,NONCOMPACTION CARDIOMYOPATHY,DISTINCT,CARDIOMYOPATHY,DIAGNOSTIC-CRITERIA,DELETION 1P36,FOLLOW-UP,MUTATIONS,HYPERTRABECULATION/NONCOMPACTION,MYOCARDIUM,TRABECULATION,Left ventricular non-compaction,heart failure,echocardiography,cardiomyopathy,genetics},
  language     = {eng},
  number       = {6},
  pages        = {625--631},
  title        = {Non-compaction cardiomyopathy : a genetically and clinically heterogeneous disorder : presentation of two cases and review of the literature},
  url          = {http://dx.doi.org/10.2143/AC.70.6.3120173},
  volume       = {70},
  year         = {2015},
}

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