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Perinatal activation of the interleukin-33 pathway promotes type 2 immunity in the developing lung

Ismé De Kleer UGent, Mirjam Kool UGent, Marjolein JW de Bruijn, Monique Willart, Justine Van Moorleghem UGent, Martijn Schuijs UGent, Maud Plantinga, Rudi Beyaert UGent, Emily Hams, Padraic G Fallon, et al. (2016) IMMUNITY. 45(6). p.1285-1298
abstract
Allergic disease originates in early life and polymorphisms in interleukin-33 gene (IL33) and IL1RL1, coding for IL-33R and decoy receptor sST2, confer allergy risk. Early life T helper 2 (Th2) cell skewing and allergy susceptibility are often seen as remnants of feto-maternal symbiosis. Here we report that shortly after birth, innate lymphoid type 2 cells (ILC2s), eosinophils, basophils, and mast cells spontaneously accumulated in developing lungs in an IL-33-dependent manner. During the phase of postnatal lung alveolarization, house dust mite exposure further increased IL-33, which boosted cytokine production in ILC2s and activated CD11b(+) dendritic cells (DCs). IL-33 suppressed IL-12p35 and induced OX40L in neonatal DCs, thus promoting Th2 cell skewing. Decoy sST2 had a strong preventive effect on asthma in the neonatal period, less so in adulthood. Thus, enhanced neonatal Th2 cell skewing to inhaled allergens results from postnatal hyperactivity of the IL-33 axis during a period of maximal lung remodeling.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
HOUSE-DUST MITE, INNATE LYMPHOID-CELLS, DENDRITIC CELLS, T-CELLS, AIRWAY, INFLAMMATION, IMPAIRED RESPONSES, ALVEOLAR FORMATION, NEONATAL IMMUNITY, RESPIRATORY-TRACT, EPITHELIAL-CELLS
journal title
IMMUNITY
Immunity
volume
45
issue
6
pages
1285 - 1298
Web of Science type
Article
Web of Science id
000392918100014
JCR category
IMMUNOLOGY
JCR impact factor
22.845 (2016)
JCR rank
3/150 (2016)
JCR quartile
1 (2016)
ISSN
1074-7613
DOI
10.1016/j.immuni.2016.10.031
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8510902
handle
http://hdl.handle.net/1854/LU-8510902
date created
2017-02-23 10:27:56
date last changed
2017-02-28 09:38:24
@article{8510902,
  abstract     = {Allergic disease originates in early life and polymorphisms in interleukin-33 gene (IL33) and IL1RL1, coding for IL-33R and decoy receptor sST2, confer allergy risk. Early life T helper 2 (Th2) cell skewing and allergy susceptibility are often seen as remnants of feto-maternal symbiosis. Here we report that shortly after birth, innate lymphoid type 2 cells (ILC2s), eosinophils, basophils, and mast cells spontaneously accumulated in developing lungs in an IL-33-dependent manner. During the phase of postnatal lung alveolarization, house dust mite exposure further increased IL-33, which boosted cytokine production in ILC2s and activated CD11b(+) dendritic cells (DCs). IL-33 suppressed IL-12p35 and induced OX40L in neonatal DCs, thus promoting Th2 cell skewing. Decoy sST2 had a strong preventive effect on asthma in the neonatal period, less so in adulthood. Thus, enhanced neonatal Th2 cell skewing to inhaled allergens results from postnatal hyperactivity of the IL-33 axis during a period of maximal lung remodeling.},
  author       = {De Kleer, Ism{\'e} and Kool, Mirjam and de Bruijn, Marjolein JW and Willart, Monique and Van Moorleghem, Justine and Schuijs, Martijn and Plantinga, Maud and Beyaert, Rudi and Hams, Emily and Fallon, Padraic G and Hammad, Hamida and Hendriks, Rudi W and Lambrecht, Bart},
  issn         = {1074-7613},
  journal      = {IMMUNITY},
  keyword      = {HOUSE-DUST MITE,INNATE LYMPHOID-CELLS,DENDRITIC CELLS,T-CELLS,AIRWAY,INFLAMMATION,IMPAIRED RESPONSES,ALVEOLAR FORMATION,NEONATAL IMMUNITY,RESPIRATORY-TRACT,EPITHELIAL-CELLS},
  language     = {eng},
  number       = {6},
  pages        = {1285--1298},
  title        = {Perinatal activation of the interleukin-33 pathway promotes type 2 immunity in the developing lung},
  url          = {http://dx.doi.org/10.1016/j.immuni.2016.10.031},
  volume       = {45},
  year         = {2016},
}

Chicago
De Kleer, Ismé, Mirjam Kool, Marjolein JW de Bruijn, Monique Willart, Justine Van Moorleghem, Martijn Schuijs, Maud Plantinga, et al. 2016. “Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung.” Immunity 45 (6): 1285–1298.
APA
De Kleer, I., Kool, M., de Bruijn, M. J., Willart, M., Van Moorleghem, J., Schuijs, M., Plantinga, M., et al. (2016). Perinatal activation of the interleukin-33 pathway promotes type 2 immunity in the developing lung. IMMUNITY, 45(6), 1285–1298.
Vancouver
1.
De Kleer I, Kool M, de Bruijn MJ, Willart M, Van Moorleghem J, Schuijs M, et al. Perinatal activation of the interleukin-33 pathway promotes type 2 immunity in the developing lung. IMMUNITY. 2016;45(6):1285–98.
MLA
De Kleer, Ismé, Mirjam Kool, Marjolein JW de Bruijn, et al. “Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung.” IMMUNITY 45.6 (2016): 1285–1298. Print.