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Intussusceptive angiogenesis and expression of Tie receptors during porcine metanephric kidney development

(2017) HISTOLOGY AND HISTOPATHOLOGY. 32(8). p.817-824
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Abstract
Intussusceptive angiogenesis (IA) is required for normal embryonic vascular development. The Tie family of receptors and their ligands, the angiopoietins, play an important role in the growth or regression of blood vessels which are important not only during development but also throughout an organism's life. The presence of IA was investigated in glomerular capillaries of the fetal porcine metanephros using Mercox II resin casts. The first signs of IA were observed in stage III glomeruli. Stage IV and V glomeruli showed numerous signs of aligned pillar formation and their successive merging to delineate the vascular entities. Furthermore, immunohistochemistry was used to determine the exact locations of the Tie receptors in the developing porcine metanephric kidneys. Tie1 and Tie2 were found in endothelial cells of all glomeruli. Strong expression of the receptors was found in podocytes of stage V glomeruli whereas a weaker expression was observed in the cuboidal epithelial cells of stage III and IV glomeruli. Remarkably, the receptors were also found in the parietal epithelium of Bowman's capsule. These findings indicate that there might be an association between Tie receptors and IA during porcine metanephric development and during glomerulogenesis in particular.
Keywords
Pillar formation, Tie1 receptor, Tie2 receptor, Angiopoietin, Glomerulus, ENDOTHELIAL PROGENITOR CELLS, TYROSINE KINASE, IN-VIVO, CHORIOALLANTOIC MEMBRANE, MICROVASCULAR GROWTH, CAPILLARY GROWTH, ANGIOPOIETIN-1, MECHANISMS, DISEASE

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Chicago
Logothetidou, Anastasia, Tim Vandecasteele, Els Van Mulken, Kimberley Vandevelde, and Pieter Cornillie. 2017. “Intussusceptive Angiogenesis and Expression of Tie Receptors During Porcine Metanephric Kidney Development.” Histology and Histopathology 32 (8): 817–824.
APA
Logothetidou, A., Vandecasteele, T., Van Mulken, E., Vandevelde, K., & Cornillie, P. (2017). Intussusceptive angiogenesis and expression of Tie receptors during porcine metanephric kidney development. HISTOLOGY AND HISTOPATHOLOGY, 32(8), 817–824.
Vancouver
1.
Logothetidou A, Vandecasteele T, Van Mulken E, Vandevelde K, Cornillie P. Intussusceptive angiogenesis and expression of Tie receptors during porcine metanephric kidney development. HISTOLOGY AND HISTOPATHOLOGY. 2017;32(8):817–24.
MLA
Logothetidou, Anastasia, Tim Vandecasteele, Els Van Mulken, et al. “Intussusceptive Angiogenesis and Expression of Tie Receptors During Porcine Metanephric Kidney Development.” HISTOLOGY AND HISTOPATHOLOGY 32.8 (2017): 817–824. Print.
@article{8510720,
  abstract     = {Intussusceptive angiogenesis (IA) is required for normal embryonic vascular development. The Tie family of receptors and their ligands, the angiopoietins, play an important role in the growth or regression of blood vessels which are important not only during development but also throughout an organism's life. The presence of IA was investigated in glomerular capillaries of the fetal porcine metanephros using Mercox II resin casts. The first signs of IA were observed in stage III glomeruli. Stage IV and V glomeruli showed numerous signs of aligned pillar formation and their successive merging to delineate the vascular entities. Furthermore, immunohistochemistry was used to determine the exact locations of the Tie receptors in the developing porcine metanephric kidneys. Tie1 and Tie2 were found in endothelial cells of all glomeruli. Strong expression of the receptors was found in podocytes of stage V glomeruli whereas a weaker expression was observed in the cuboidal epithelial cells of stage III and IV glomeruli. Remarkably, the receptors were also found in the parietal epithelium of Bowman's capsule. These findings indicate that there might be an association between Tie receptors and IA during porcine metanephric development and during glomerulogenesis in particular.},
  author       = {Logothetidou, Anastasia and Vandecasteele, Tim and Van Mulken, Els and Vandevelde, Kimberley and Cornillie, Pieter},
  issn         = {0213-3911},
  journal      = {HISTOLOGY AND HISTOPATHOLOGY},
  language     = {eng},
  number       = {8},
  pages        = {817--824},
  title        = {Intussusceptive angiogenesis and expression of Tie receptors during porcine metanephric kidney development},
  url          = {http://dx.doi.org/10.14670/HH-11-850},
  volume       = {32},
  year         = {2017},
}

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