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Dedifferentiated liposarcoma of the retroperitoneum with heterologous osteosarcomatous differentiation and a striking aneurysmal bone cyst-like morphology

Carole Van Haverbeke, Jo Van Dorpe (UGent) , Evelyne Lecoutere, Uta Flucke, Liesbeth Ferdinande (UGent) and David Creytens (UGent)
(2017) INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY. 25(4). p.374-378
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Abstract
A 69-year-old woman with a 10-year medical history of recurrent retroperitoneal dedifferentiated liposarcoma presented with a 3-cm large hemorrhagic and multicystic left-sided retroperitoneal mass. Histopathological examination of the resected specimen showed a heterogeneous, high-grade mesenchymal nonlipogenic tumor with areas of osteoblastic/osteosarcomatous differentiation and aneurysmal bone cyst-like features. Based on the clinical presentation, the morphology, and the supportive immunohistochemical and molecular findings (MDM2 overexpression and amplification of the MDM2 gene, respectively), a diagnosis of a dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation and an aneurysmal bone cyst-like morphology was made. To the best of our knowledge, this is the first description of aneurysmal bone cyst-like morphology in dedifferentiated liposarcoma, further expanding the broad morphological spectrum of dedifferentiated liposarcoma.
Keywords
liposarcoma, dedifferentiated liposarcoma, osteosarcomatous, aneurysmal bone cyst, MDM2, PLEOMORPHIC SARCOMAS, MYOGENIC DIFFERENTIATION, CDK4, MDM2, COMPONENT, CELL

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MLA
Van Haverbeke, Carole, et al. “Dedifferentiated Liposarcoma of the Retroperitoneum with Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-like Morphology.” INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, vol. 25, no. 4, 2017, pp. 374–78, doi:10.1177/1066896917693093.
APA
Van Haverbeke, C., Van Dorpe, J., Lecoutere, E., Flucke, U., Ferdinande, L., & Creytens, D. (2017). Dedifferentiated liposarcoma of the retroperitoneum with heterologous osteosarcomatous differentiation and a striking aneurysmal bone cyst-like morphology. INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 25(4), 374–378. https://doi.org/10.1177/1066896917693093
Chicago author-date
Van Haverbeke, Carole, Jo Van Dorpe, Evelyne Lecoutere, Uta Flucke, Liesbeth Ferdinande, and David Creytens. 2017. “Dedifferentiated Liposarcoma of the Retroperitoneum with Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-like Morphology.” INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY 25 (4): 374–78. https://doi.org/10.1177/1066896917693093.
Chicago author-date (all authors)
Van Haverbeke, Carole, Jo Van Dorpe, Evelyne Lecoutere, Uta Flucke, Liesbeth Ferdinande, and David Creytens. 2017. “Dedifferentiated Liposarcoma of the Retroperitoneum with Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-like Morphology.” INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY 25 (4): 374–378. doi:10.1177/1066896917693093.
Vancouver
1.
Van Haverbeke C, Van Dorpe J, Lecoutere E, Flucke U, Ferdinande L, Creytens D. Dedifferentiated liposarcoma of the retroperitoneum with heterologous osteosarcomatous differentiation and a striking aneurysmal bone cyst-like morphology. INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY. 2017;25(4):374–8.
IEEE
[1]
C. Van Haverbeke, J. Van Dorpe, E. Lecoutere, U. Flucke, L. Ferdinande, and D. Creytens, “Dedifferentiated liposarcoma of the retroperitoneum with heterologous osteosarcomatous differentiation and a striking aneurysmal bone cyst-like morphology,” INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, vol. 25, no. 4, pp. 374–378, 2017.
@article{8510592,
  abstract     = {{A 69-year-old woman with a 10-year medical history of recurrent retroperitoneal dedifferentiated liposarcoma presented with a 3-cm large hemorrhagic and multicystic left-sided retroperitoneal mass. Histopathological examination of the resected specimen showed a heterogeneous, high-grade mesenchymal nonlipogenic tumor with areas of osteoblastic/osteosarcomatous differentiation and aneurysmal bone cyst-like features. Based on the clinical presentation, the morphology, and the supportive immunohistochemical and molecular findings (MDM2 overexpression and amplification of the MDM2 gene, respectively), a diagnosis of a dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation and an aneurysmal bone cyst-like morphology was made. To the best of our knowledge, this is the first description of aneurysmal bone cyst-like morphology in dedifferentiated liposarcoma, further expanding the broad morphological spectrum of dedifferentiated liposarcoma.}},
  author       = {{Van Haverbeke, Carole and Van Dorpe, Jo and Lecoutere, Evelyne and Flucke, Uta and Ferdinande, Liesbeth and Creytens, David}},
  issn         = {{1066-8969}},
  journal      = {{INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY}},
  keywords     = {{liposarcoma,dedifferentiated liposarcoma,osteosarcomatous,aneurysmal bone cyst,MDM2,PLEOMORPHIC SARCOMAS,MYOGENIC DIFFERENTIATION,CDK4,MDM2,COMPONENT,CELL}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{374--378}},
  title        = {{Dedifferentiated liposarcoma of the retroperitoneum with heterologous osteosarcomatous differentiation and a striking aneurysmal bone cyst-like morphology}},
  url          = {{http://doi.org/10.1177/1066896917693093}},
  volume       = {{25}},
  year         = {{2017}},
}
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