Dedifferentiated liposarcoma of the retroperitoneum with heterologous osteosarcomatous differentiation and a striking aneurysmal bone cyst-like morphology
- Author
- Carole Van Haverbeke, Jo Van Dorpe (UGent) , Evelyne Lecoutere, Uta Flucke, Liesbeth Ferdinande (UGent) and David Creytens (UGent)
- Organization
- Abstract
- A 69-year-old woman with a 10-year medical history of recurrent retroperitoneal dedifferentiated liposarcoma presented with a 3-cm large hemorrhagic and multicystic left-sided retroperitoneal mass. Histopathological examination of the resected specimen showed a heterogeneous, high-grade mesenchymal nonlipogenic tumor with areas of osteoblastic/osteosarcomatous differentiation and aneurysmal bone cyst-like features. Based on the clinical presentation, the morphology, and the supportive immunohistochemical and molecular findings (MDM2 overexpression and amplification of the MDM2 gene, respectively), a diagnosis of a dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation and an aneurysmal bone cyst-like morphology was made. To the best of our knowledge, this is the first description of aneurysmal bone cyst-like morphology in dedifferentiated liposarcoma, further expanding the broad morphological spectrum of dedifferentiated liposarcoma.
- Keywords
- liposarcoma, dedifferentiated liposarcoma, osteosarcomatous, aneurysmal bone cyst, MDM2, PLEOMORPHIC SARCOMAS, MYOGENIC DIFFERENTIATION, CDK4, MDM2, COMPONENT, CELL
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8510592
- MLA
- Van Haverbeke, Carole, et al. “Dedifferentiated Liposarcoma of the Retroperitoneum with Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-like Morphology.” INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, vol. 25, no. 4, 2017, pp. 374–78, doi:10.1177/1066896917693093.
- APA
- Van Haverbeke, C., Van Dorpe, J., Lecoutere, E., Flucke, U., Ferdinande, L., & Creytens, D. (2017). Dedifferentiated liposarcoma of the retroperitoneum with heterologous osteosarcomatous differentiation and a striking aneurysmal bone cyst-like morphology. INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 25(4), 374–378. https://doi.org/10.1177/1066896917693093
- Chicago author-date
- Van Haverbeke, Carole, Jo Van Dorpe, Evelyne Lecoutere, Uta Flucke, Liesbeth Ferdinande, and David Creytens. 2017. “Dedifferentiated Liposarcoma of the Retroperitoneum with Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-like Morphology.” INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY 25 (4): 374–78. https://doi.org/10.1177/1066896917693093.
- Chicago author-date (all authors)
- Van Haverbeke, Carole, Jo Van Dorpe, Evelyne Lecoutere, Uta Flucke, Liesbeth Ferdinande, and David Creytens. 2017. “Dedifferentiated Liposarcoma of the Retroperitoneum with Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-like Morphology.” INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY 25 (4): 374–378. doi:10.1177/1066896917693093.
- Vancouver
- 1.Van Haverbeke C, Van Dorpe J, Lecoutere E, Flucke U, Ferdinande L, Creytens D. Dedifferentiated liposarcoma of the retroperitoneum with heterologous osteosarcomatous differentiation and a striking aneurysmal bone cyst-like morphology. INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY. 2017;25(4):374–8.
- IEEE
- [1]C. Van Haverbeke, J. Van Dorpe, E. Lecoutere, U. Flucke, L. Ferdinande, and D. Creytens, “Dedifferentiated liposarcoma of the retroperitoneum with heterologous osteosarcomatous differentiation and a striking aneurysmal bone cyst-like morphology,” INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, vol. 25, no. 4, pp. 374–378, 2017.
@article{8510592, abstract = {{A 69-year-old woman with a 10-year medical history of recurrent retroperitoneal dedifferentiated liposarcoma presented with a 3-cm large hemorrhagic and multicystic left-sided retroperitoneal mass. Histopathological examination of the resected specimen showed a heterogeneous, high-grade mesenchymal nonlipogenic tumor with areas of osteoblastic/osteosarcomatous differentiation and aneurysmal bone cyst-like features. Based on the clinical presentation, the morphology, and the supportive immunohistochemical and molecular findings (MDM2 overexpression and amplification of the MDM2 gene, respectively), a diagnosis of a dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation and an aneurysmal bone cyst-like morphology was made. To the best of our knowledge, this is the first description of aneurysmal bone cyst-like morphology in dedifferentiated liposarcoma, further expanding the broad morphological spectrum of dedifferentiated liposarcoma.}}, author = {{Van Haverbeke, Carole and Van Dorpe, Jo and Lecoutere, Evelyne and Flucke, Uta and Ferdinande, Liesbeth and Creytens, David}}, issn = {{1066-8969}}, journal = {{INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY}}, keywords = {{liposarcoma,dedifferentiated liposarcoma,osteosarcomatous,aneurysmal bone cyst,MDM2,PLEOMORPHIC SARCOMAS,MYOGENIC DIFFERENTIATION,CDK4,MDM2,COMPONENT,CELL}}, language = {{eng}}, number = {{4}}, pages = {{374--378}}, title = {{Dedifferentiated liposarcoma of the retroperitoneum with heterologous osteosarcomatous differentiation and a striking aneurysmal bone cyst-like morphology}}, url = {{http://doi.org/10.1177/1066896917693093}}, volume = {{25}}, year = {{2017}}, }
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