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Time-saving screening for diabetes in patients with coronary artery disease : a report from EUROASPIRE IV

(2016) BMJ OPEN. 6(12).
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Abstract
Background: WHO advocates 2-hour oral glucose tolerance test (OGTT) for detecting diabetes mellitus (DM). OGTT is the most sensitive method to detect DM in patients with coronary artery disease (CAD). Considered time consuming, the use of OGTT is unsatisfactory. A 1-hour plasma glucose (1hPG) test has not been evaluated as an alternative in patients with CAD. Objectives: To create an algorithm based on glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and 1hPG limiting the need of a 2-hour plasma glucose (2hPG) in patients with CAD. Methods: 951 patients with CAD without DM underwent OGTT. A 2hPG >= 11.1 mmol/L was the reference for undiagnosed DM. The yield of HbA1c, FPG and 1hPG was compared with that of 2hPG. Results: Mean FPG was 6.2 +/- 0.9 mmol/L, and mean HbA1c 5.8 +/- 0.4%. Based on 2hPG >= 11.1 mmol/L 122 patients (13%) had DM. There was no value for the combination of HbA1c and FPG to rule out or in DM (HbA1c >= 6.5%; FPG >= 7.0 mmol/L). In receiver operating characteristic analysis a 1hPG >= 12 mmol/L balanced sensitivity and specificity for detecting DM (both=82%; positive and negative predictive values 40% and 97%). A combination of FPG<6.5 mmol/L and 1hPG<11 mmol/L excluded 99% of DM. A combination of FPG>8.0 mmol/L and 1hPG>15 mmol/L identified 100% of patients with DM. Conclusions: Based on its satisfactory accuracy to detect DM an algorithm is proposed for screening for DM in patients with CAD decreasing the need for a 2-hour OGTT by 71%.
Keywords
ACUTE MYOCARDIAL-INFARCTION, GLUCOSE-TOLERANCE TEST, HOUR POSTLOAD, HYPERGLYCEMIA, FASTING PLASMA-GLUCOSE, CARDIOVASCULAR-DISEASE, EURO, HEART, RISK, MELLITUS, BLOOD, ATHEROSCLEROSIS

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Chicago
Gyberg, Viveca, Dirk De Bacquer, Kornelia Kotseva, Gui De Backer, Oliver Schnell, Jaakko Tuomilehto, David Wood, and Lars Ryden. 2016. “Time-saving Screening for Diabetes in Patients with Coronary Artery Disease : a Report from EUROASPIRE IV.” Bmj Open 6 (12).
APA
Gyberg, V., De Bacquer, D., Kotseva, K., De Backer, G., Schnell, O., Tuomilehto, J., Wood, D., et al. (2016). Time-saving screening for diabetes in patients with coronary artery disease : a report from EUROASPIRE IV. BMJ OPEN, 6(12).
Vancouver
1.
Gyberg V, De Bacquer D, Kotseva K, De Backer G, Schnell O, Tuomilehto J, et al. Time-saving screening for diabetes in patients with coronary artery disease : a report from EUROASPIRE IV. BMJ OPEN. 2016;6(12).
MLA
Gyberg, Viveca, Dirk De Bacquer, Kornelia Kotseva, et al. “Time-saving Screening for Diabetes in Patients with Coronary Artery Disease : a Report from EUROASPIRE IV.” BMJ OPEN 6.12 (2016): n. pag. Print.
@article{8510571,
  abstract     = {Background: WHO advocates 2-hour oral glucose tolerance test (OGTT) for detecting diabetes mellitus (DM). OGTT is the most sensitive method to detect DM in patients with coronary artery disease (CAD). Considered time consuming, the use of OGTT is unsatisfactory. A 1-hour plasma glucose (1hPG) test has not been evaluated as an alternative in patients with CAD. 
Objectives: To create an algorithm based on glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and 1hPG limiting the need of a 2-hour plasma glucose (2hPG) in patients with CAD. 
Methods: 951 patients with CAD without DM underwent OGTT. A 2hPG {\textrangle}= 11.1 mmol/L was the reference for undiagnosed DM. The yield of HbA1c, FPG and 1hPG was compared with that of 2hPG. 
Results: Mean FPG was 6.2 +/- 0.9 mmol/L, and mean HbA1c 5.8 +/- 0.4\%. Based on 2hPG {\textrangle}= 11.1 mmol/L 122 patients (13\%) had DM. There was no value for the combination of HbA1c and FPG to rule out or in DM (HbA1c {\textrangle}= 6.5\%; FPG {\textrangle}= 7.0 mmol/L). In receiver operating characteristic analysis a 1hPG {\textrangle}= 12 mmol/L balanced sensitivity and specificity for detecting DM (both=82\%; positive and negative predictive values 40\% and 97\%). A combination of FPG{\textlangle}6.5 mmol/L and 1hPG{\textlangle}11 mmol/L excluded 99\% of DM. A combination of FPG{\textrangle}8.0 mmol/L and 1hPG{\textrangle}15 mmol/L identified 100\% of patients with DM. 
Conclusions: Based on its satisfactory accuracy to detect DM an algorithm is proposed for screening for DM in patients with CAD decreasing the need for a 2-hour OGTT by 71\%.},
  articleno    = {e013835},
  author       = {Gyberg, Viveca and De Bacquer, Dirk and Kotseva, Kornelia and De Backer, Gui and Schnell, Oliver and Tuomilehto, Jaakko and Wood, David and Ryden, Lars},
  issn         = {2044-6055},
  journal      = {BMJ OPEN},
  keyword      = {ACUTE MYOCARDIAL-INFARCTION,GLUCOSE-TOLERANCE TEST,HOUR POSTLOAD,HYPERGLYCEMIA,FASTING PLASMA-GLUCOSE,CARDIOVASCULAR-DISEASE,EURO,HEART,RISK,MELLITUS,BLOOD,ATHEROSCLEROSIS},
  language     = {eng},
  number       = {12},
  pages        = {7},
  title        = {Time-saving screening for diabetes in patients with coronary artery disease : a report from EUROASPIRE IV},
  url          = {http://dx.doi.org/10.1136/bmjopen-2016-013835},
  volume       = {6},
  year         = {2016},
}

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