- Author
- Niki DJ Ubags, Renee D Stapleton, Juanita H.J. Vernooy, Elianne Burg (UGent) , Jenna Bement, Catherine M Hayes, Sebastian Ventrone, Lennart Zabeau (UGent) , Jan Tavernier (UGent) , Matthew E Poynter, Polly E Parsons, Anne E Dixon, Matthew J Wargo, Benjamin Littenberg, Emiel FM Wouters and Benjamin T Suratt
- Organization
- Abstract
- We have previously reported that obesity attenuates pulmonary inflammation in both patients with acute respiratory distress syndrome (ARDS) and in mouse models of the disease. We hypothesized that obesity-associated hyperleptinemia, and not body mass per se, drives attenuation of the pulmonary inflammatory response and that this effect could also impair the host response to pneumonia. We examined the correlation between circulating leptin levels and risk, severity, and outcome of pneumonia in 2 patient cohorts (NHANES III and ARDSNet-ALVEOLI) and in mouse models of diet-induced obesity and lean hyperleptinemia. Plasma leptin levels in ambulatory subjects (NHANES) correlated positively with annual risk of respiratory infection independent of BMI. In patients with severe pneumonia resulting in ARDS (ARDSNet-ALVEOLI), plasma leptin levels were found to correlate positively with subsequent mortality. In obese mice with pneumonia, plasma leptin levels were associated with pneumonia severity, and in obese mice with sterile lung injury, leptin levels were inversely related to bronchoalveolar lavage neutrophilia, as well as to plasma IL-6 and G-CSF levels. These results were recapitulated in lean mice with experimentally induced hyperleptinemia. Our findings suggest that the association between obesity and elevated risk of pulmonary infection may be driven by hyperleptinemia.
- Keywords
- COMMUNITY-ACQUIRED PNEUMONIA, ACUTE LUNG INJURY, RESPIRATORY-DISTRESS-SYNDROME, INDUCED OBESE MICE, BODY-MASS INDEX, SERUM LEPTIN LEVELS, INSULIN-RESISTANCE, INFLUENZA-VIRUS, RISK-FACTORS, BACTERIAL CLEARANCE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8510262
- MLA
- Ubags, Niki DJ, et al. “Hyperleptinemia Is Associated with Impaired Pulmonary Host Defense.” JCI INSIGHT, vol. 1, no. 8, 2016, doi:10.1172/jci.insight.82101.
- APA
- Ubags, N. D., Stapleton, R. D., Vernooy, J. H. J., Burg, E., Bement, J., Hayes, C. M., … Suratt, B. T. (2016). Hyperleptinemia is associated with impaired pulmonary host defense. JCI INSIGHT, 1(8). https://doi.org/10.1172/jci.insight.82101
- Chicago author-date
- Ubags, Niki DJ, Renee D Stapleton, Juanita H.J. Vernooy, Elianne Burg, Jenna Bement, Catherine M Hayes, Sebastian Ventrone, et al. 2016. “Hyperleptinemia Is Associated with Impaired Pulmonary Host Defense.” JCI INSIGHT 1 (8). https://doi.org/10.1172/jci.insight.82101.
- Chicago author-date (all authors)
- Ubags, Niki DJ, Renee D Stapleton, Juanita H.J. Vernooy, Elianne Burg, Jenna Bement, Catherine M Hayes, Sebastian Ventrone, Lennart Zabeau, Jan Tavernier, Matthew E Poynter, Polly E Parsons, Anne E Dixon, Matthew J Wargo, Benjamin Littenberg, Emiel FM Wouters, and Benjamin T Suratt. 2016. “Hyperleptinemia Is Associated with Impaired Pulmonary Host Defense.” JCI INSIGHT 1 (8). doi:10.1172/jci.insight.82101.
- Vancouver
- 1.Ubags ND, Stapleton RD, Vernooy JHJ, Burg E, Bement J, Hayes CM, et al. Hyperleptinemia is associated with impaired pulmonary host defense. JCI INSIGHT. 2016;1(8).
- IEEE
- [1]N. D. Ubags et al., “Hyperleptinemia is associated with impaired pulmonary host defense,” JCI INSIGHT, vol. 1, no. 8, 2016.
@article{8510262,
abstract = {{We have previously reported that obesity attenuates pulmonary inflammation in both patients with acute respiratory distress syndrome (ARDS) and in mouse models of the disease. We hypothesized that obesity-associated hyperleptinemia, and not body mass per se, drives attenuation of the pulmonary inflammatory response and that this effect could also impair the host response to pneumonia. We examined the correlation between circulating leptin levels and risk, severity, and outcome of pneumonia in 2 patient cohorts (NHANES III and ARDSNet-ALVEOLI) and in mouse models of diet-induced obesity and lean hyperleptinemia. Plasma leptin levels in ambulatory subjects (NHANES) correlated positively with annual risk of respiratory infection independent of BMI. In patients with severe pneumonia resulting in ARDS (ARDSNet-ALVEOLI), plasma leptin levels were found to correlate positively with subsequent mortality. In obese mice with pneumonia, plasma leptin levels were associated with pneumonia severity, and in obese mice with sterile lung injury, leptin levels were inversely related to bronchoalveolar lavage neutrophilia, as well as to plasma IL-6 and G-CSF levels. These results were recapitulated in lean mice with experimentally induced hyperleptinemia. Our findings suggest that the association between obesity and elevated risk of pulmonary infection may be driven by hyperleptinemia.}},
articleno = {{e82101}},
author = {{Ubags, Niki DJ and Stapleton, Renee D and Vernooy, Juanita H.J. and Burg, Elianne and Bement, Jenna and Hayes, Catherine M and Ventrone, Sebastian and Zabeau, Lennart and Tavernier, Jan and Poynter, Matthew E and Parsons, Polly E and Dixon, Anne E and Wargo, Matthew J and Littenberg, Benjamin and Wouters, Emiel FM and Suratt, Benjamin T}},
issn = {{2379-3708}},
journal = {{JCI INSIGHT}},
keywords = {{COMMUNITY-ACQUIRED PNEUMONIA,ACUTE LUNG INJURY,RESPIRATORY-DISTRESS-SYNDROME,INDUCED OBESE MICE,BODY-MASS INDEX,SERUM LEPTIN LEVELS,INSULIN-RESISTANCE,INFLUENZA-VIRUS,RISK-FACTORS,BACTERIAL CLEARANCE}},
language = {{eng}},
number = {{8}},
pages = {{13}},
title = {{Hyperleptinemia is associated with impaired pulmonary host defense}},
url = {{http://doi.org/10.1172/jci.insight.82101}},
volume = {{1}},
year = {{2016}},
}
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