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Impact of bariatric surgery on carotid artery inflammation and the metabolic activity in different adipose tissues

(2015) MEDICINE. 94(20).
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Organization
Abstract
In this study, we unravel a molecular imaging marker correlated with the known reduction of cardiovascular events (most commonly related to vulnerable plaques) in morbidly obese patients after bariatric surgery (BaS). We prospectively imaged 10 morbidly obese subjects with F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography/computed tomography before and 1 year after BaS. F-18-FDG uptake-which is enhanced in inflamed, atherosclerotic vessels and in metabolically active adipose tissues-was quantified in the carotids, pericardial adipose tissue (PAT), visceral adipose tissue (VAT), as well as brown adipose tissue (BAT). The degree of carotid inflammation was compared to lean and overweight controls. Carotid inflammation significantly declined leading to an F-18-FDG uptake comparable to the 2 control groups. Metabolic activity significantly decreased in PAT and VAT and increased in BAT. BaS leads to a normalization of carotid artery inflammation and a beneficial impact on the metabolic activity in PAT, VAT, and BAT that is related to the metabolic syndrome observed in this patient group.
Keywords
VESSEL WALL INFLAMMATION, MORBIDLY OBESE-PATIENTS, LONG-TERM MORTALITY, CARDIOVASCULAR-DISEASE, RISK-FACTORS, CORONARY ATHEROSCLEROSIS, SLEEVE, GASTRECTOMY, F-18-FDG PET/CT, GASTRIC BYPASS, WEIGHT-LOSS

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Chicago
Bucerius, Jan, Guy HEJ Vijgen, Boudewijn Brans, Nicole D Bouvy, Matthias Bauwens, James HF Rudd, Bas Havekes, Zahi A Fayad, Wouter D van Marken Lichtenbelt, and Felix M Mottaghy. 2015. “Impact of Bariatric Surgery on Carotid Artery Inflammation and the Metabolic Activity in Different Adipose Tissues.” Medicine 94 (20).
APA
Bucerius, J., Vijgen, G. H., Brans, B., Bouvy, N. D., Bauwens, M., Rudd, J. H., Havekes, B., et al. (2015). Impact of bariatric surgery on carotid artery inflammation and the metabolic activity in different adipose tissues. MEDICINE, 94(20).
Vancouver
1.
Bucerius J, Vijgen GH, Brans B, Bouvy ND, Bauwens M, Rudd JH, et al. Impact of bariatric surgery on carotid artery inflammation and the metabolic activity in different adipose tissues. MEDICINE. 2015;94(20).
MLA
Bucerius, Jan et al. “Impact of Bariatric Surgery on Carotid Artery Inflammation and the Metabolic Activity in Different Adipose Tissues.” MEDICINE 94.20 (2015): n. pag. Print.
@article{8510239,
  abstract     = {In this study, we unravel a molecular imaging marker correlated with the known reduction of cardiovascular events (most commonly related to vulnerable plaques) in morbidly obese patients after bariatric surgery (BaS). 
We prospectively imaged 10 morbidly obese subjects with F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography/computed tomography before and 1 year after BaS. F-18-FDG uptake-which is enhanced in inflamed, atherosclerotic vessels and in metabolically active adipose tissues-was quantified in the carotids, pericardial adipose tissue (PAT), visceral adipose tissue (VAT), as well as brown adipose tissue (BAT). The degree of carotid inflammation was compared to lean and overweight controls. 
Carotid inflammation significantly declined leading to an F-18-FDG uptake comparable to the 2 control groups. Metabolic activity significantly decreased in PAT and VAT and increased in BAT. 
BaS leads to a normalization of carotid artery inflammation and a beneficial impact on the metabolic activity in PAT, VAT, and BAT that is related to the metabolic syndrome observed in this patient group.},
  articleno    = {e725},
  author       = {Bucerius, Jan and Vijgen, Guy HEJ and Brans, Boudewijn and Bouvy, Nicole D and Bauwens, Matthias and Rudd, James HF and Havekes, Bas and Fayad, Zahi A and van Marken Lichtenbelt, Wouter D and Mottaghy, Felix M},
  issn         = {0025-7974},
  journal      = {MEDICINE},
  keywords     = {VESSEL WALL INFLAMMATION,MORBIDLY OBESE-PATIENTS,LONG-TERM MORTALITY,CARDIOVASCULAR-DISEASE,RISK-FACTORS,CORONARY ATHEROSCLEROSIS,SLEEVE,GASTRECTOMY,F-18-FDG PET/CT,GASTRIC BYPASS,WEIGHT-LOSS},
  language     = {eng},
  number       = {20},
  pages        = {9},
  title        = {Impact of bariatric surgery on carotid artery inflammation and the metabolic activity in different adipose tissues},
  url          = {http://dx.doi.org/10.1097/MD.0000000000000725},
  volume       = {94},
  year         = {2015},
}

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