Advanced search

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

(2015) NATURE MEDICINE. 21(8). p.863-865
Author
Organization
Abstract
Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 degrees C) increased peripheral insulin sensitivity by similar to 43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
Keywords
BROWN ADIPOSE-TISSUE, MITOCHONDRIAL-FUNCTION, METABOLIC FLEXIBILITY, ENERGY-EXPENDITURE, GLUCOSE-UPTAKE, THERMOGENESIS, FAT, HUMANS, MUSCLE, HOMEOSTASIS

Citation

Please use this url to cite or link to this publication:

Chicago
Hanssen, Mark JW, Joris Hoeks, Boudewijn Brans, Anouk AJJ van der Lans, Gert Schaart, Jose J van den Driessche, Johanna A Jorgensen, et al. 2015. “Short-term Cold Acclimation Improves Insulin Sensitivity in Patients with Type 2 Diabetes Mellitus.” Nature Medicine 21 (8): 863–865.
APA
Hanssen, M. J., Hoeks, J., Brans, B., van der Lans, A. A., Schaart, G., van den Driessche, J. J., Jorgensen, J. A., et al. (2015). Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. NATURE MEDICINE, 21(8), 863–865.
Vancouver
1.
Hanssen MJ, Hoeks J, Brans B, van der Lans AA, Schaart G, van den Driessche JJ, et al. Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. NATURE MEDICINE. 2015;21(8):863–5.
MLA
Hanssen, Mark JW, Joris Hoeks, Boudewijn Brans, et al. “Short-term Cold Acclimation Improves Insulin Sensitivity in Patients with Type 2 Diabetes Mellitus.” NATURE MEDICINE 21.8 (2015): 863–865. Print.
@article{8510236,
  abstract     = {Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 degrees C) increased peripheral insulin sensitivity by similar to 43\% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.},
  author       = {Hanssen, Mark JW and Hoeks, Joris and Brans, Boudewijn and van der Lans, Anouk AJJ and Schaart, Gert and van den Driessche, Jose J and Jorgensen, Johanna A and Boekschoten, Mark V and Hesselink, Matthijs KC and Havekes, Bas and Kersten, Sander and Mottaghy, Felix M and Lichtenbelt, Wouter D van Marken and Schrauwen, Patrick},
  issn         = {1078-8956},
  journal      = {NATURE MEDICINE},
  keyword      = {BROWN ADIPOSE-TISSUE,MITOCHONDRIAL-FUNCTION,METABOLIC FLEXIBILITY,ENERGY-EXPENDITURE,GLUCOSE-UPTAKE,THERMOGENESIS,FAT,HUMANS,MUSCLE,HOMEOSTASIS},
  language     = {eng},
  number       = {8},
  pages        = {863--865},
  title        = {Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus},
  url          = {http://dx.doi.org/10.1038/nm.3891},
  volume       = {21},
  year         = {2015},
}

Altmetric
View in Altmetric
Web of Science
Times cited: