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Synthesis of pyrido-annelated diazepines, oxazepines and thiazepines

Koen Muylaert (UGent) , Martyna Jatczak (UGent) , Sven Mangelinckx (UGent) and Christian Stevens (UGent)
(2016) CURRENT MEDICINAL CHEMISTRY. 23(42). p.4784-4823
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Abstract
The immense amount of research on benzodiazepines resulted in the synthesis of heterocycle-fused diazepine derivatives with potential pharmacological activity. Pyridoazepines are recognized to be active in the central nervous system and have a comparable activity to the well-known benzodiazepines. This makes the synthesis and the study of pyridodiazepines an important research topic. This review comprises of the synthesis and activity of pyridodiazepines, pyridooxazepines and pyridothiazepines. Although these structures have a great similarity with benzodiazepines, much less work has been published on their synthesis or derivatization. Therefore, there is a need to further develop these classes of underexplored scaffolds, in search for new chemistry, new methodology and hence new biological features.
Keywords
Fused-ring system, nitrogen heterocycles, pyrido-annelated, diazepines, oxazepines, thiazepines, ring formation, synthesis, MICROWAVE-ASSISTED SYNTHESIS, SOLID-PHASE SYNTHESIS, ENOYL-ACP REDUCTASE, SUBTYPE-3 BRS-3 AGONISTS, ACTIVITY IN-VITRO, PRIVILEGED STRUCTURES, COMBINATORIAL LIBRARIES, MEDICINAL CHEMISTRY, DRUG DISCOVERY, HETEROTRICYCLIC SYSTEMS

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Chicago
Muylaert, Koen, Martyna Jatczak, Sven Mangelinckx, and Christian Stevens. 2016. “Synthesis of Pyrido-annelated Diazepines, Oxazepines and Thiazepines.” Current Medicinal Chemistry 23 (42): 4784–4823.
APA
Muylaert, Koen, Jatczak, M., Mangelinckx, S., & Stevens, C. (2016). Synthesis of pyrido-annelated diazepines, oxazepines and thiazepines. CURRENT MEDICINAL CHEMISTRY, 23(42), 4784–4823.
Vancouver
1.
Muylaert K, Jatczak M, Mangelinckx S, Stevens C. Synthesis of pyrido-annelated diazepines, oxazepines and thiazepines. CURRENT MEDICINAL CHEMISTRY. 2016;23(42):4784–823.
MLA
Muylaert, Koen et al. “Synthesis of Pyrido-annelated Diazepines, Oxazepines and Thiazepines.” CURRENT MEDICINAL CHEMISTRY 23.42 (2016): 4784–4823. Print.
@article{8509866,
  abstract     = {The immense amount of research on benzodiazepines resulted in the synthesis of heterocycle-fused diazepine derivatives with potential pharmacological activity. Pyridoazepines are recognized to be active in the central nervous system and have a comparable activity to the well-known benzodiazepines. This makes the synthesis and the study of pyridodiazepines an important research topic. This review comprises of the synthesis and activity of pyridodiazepines, pyridooxazepines and pyridothiazepines. Although these structures have a great similarity with benzodiazepines, much less work has been published on their synthesis or derivatization. Therefore, there is a need to further develop these classes of underexplored scaffolds, in search for new chemistry, new methodology and hence new biological features.},
  author       = {Muylaert, Koen and Jatczak, Martyna and Mangelinckx, Sven and Stevens, Christian},
  issn         = {0929-8673},
  journal      = {CURRENT MEDICINAL CHEMISTRY},
  keywords     = {Fused-ring system,nitrogen heterocycles,pyrido-annelated,diazepines,oxazepines,thiazepines,ring formation,synthesis,MICROWAVE-ASSISTED SYNTHESIS,SOLID-PHASE SYNTHESIS,ENOYL-ACP REDUCTASE,SUBTYPE-3 BRS-3 AGONISTS,ACTIVITY IN-VITRO,PRIVILEGED STRUCTURES,COMBINATORIAL LIBRARIES,MEDICINAL CHEMISTRY,DRUG DISCOVERY,HETEROTRICYCLIC SYSTEMS},
  language     = {eng},
  number       = {42},
  pages        = {4784--4823},
  title        = {Synthesis of pyrido-annelated diazepines, oxazepines and thiazepines},
  url          = {http://dx.doi.org/10.2174/0929867323666160920101332},
  volume       = {23},
  year         = {2016},
}

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