Advanced search
1 file | 758.27 KB

Host Th1/Th2 immune response to Taenia solium cyst antigens in relation to cyst burden of neurocysticercosis

(2016) PARASITE IMMUNOLOGY. 38(10). p.628-634
Author
Organization
Project
VLIR-UDC Flemish travel grants
Abstract
Neurocysticercosis (NCC), Taenia solium larval infection of the brain, is an important cause of acquired seizures in endemic countries, which relate to number, location and degenerating cysts in the brain. Multicyst infections are common in endemic countries although single-cyst infection prevails in India. Single-cyst infections in an endemic country suggest a role for host immunity limiting the infection. This study examined ex vivo CD4(+) T cells and in vitro Th1 and Th2 cytokine responses to T.solium cyst antigens of peripheral blood mononuclear cells of healthy subjects from endemic and nonendemic regions and of single- and multicyst-infected patients for association with cyst burden of NCC. T.solium cyst antigens elicited a Th1 cytokine response in healthy subjects of T.solium-endemic and T.solium-non-endemic regions and those with single-cyst infections and a Th2 cytokine response from subjects with multicyst neurocysticercosis. Multicyst neurocysticercosis subjects also exhibited low levels of effector memory CD4(+) T cells. Th1 cytokine response of T.solium exposure and low infectious loads may aid in limiting cyst number. Th2 cytokines and low effector T cells may enable multiple-cyst infections to establish and persist.
Keywords
CD4(+) T cells, cellular immunity, India, neurocysticercosis, Taenia solium cyst antigens, SOLITARY CYSTICERCUS GRANULOMA, T-CELLS, INDIAN PATIENTS, PARASITE, CRASSICEPS, RESISTANCE, INFECTION, DISEASE, INTERLEUKIN-10, PROFILE

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 758.27 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Tharmalingam, J, AT Prabhakar, P Gangadaran, Pierre Dorny, Jozef Vercruysse, Peter Geldhof, V Rajshekhar, M Alexander, and A Oommen. 2016. “Host Th1/Th2 Immune Response to Taenia Solium Cyst Antigens in Relation to Cyst Burden of Neurocysticercosis.” Parasite Immunology 38 (10): 628–634.
APA
Tharmalingam, J., Prabhakar, A., Gangadaran, P., Dorny, P., Vercruysse, J., Geldhof, P., Rajshekhar, V., et al. (2016). Host Th1/Th2 immune response to Taenia solium cyst antigens in relation to cyst burden of neurocysticercosis. PARASITE IMMUNOLOGY, 38(10), 628–634.
Vancouver
1.
Tharmalingam J, Prabhakar A, Gangadaran P, Dorny P, Vercruysse J, Geldhof P, et al. Host Th1/Th2 immune response to Taenia solium cyst antigens in relation to cyst burden of neurocysticercosis. PARASITE IMMUNOLOGY. 2016;38(10):628–34.
MLA
Tharmalingam, J et al. “Host Th1/Th2 Immune Response to Taenia Solium Cyst Antigens in Relation to Cyst Burden of Neurocysticercosis.” PARASITE IMMUNOLOGY 38.10 (2016): 628–634. Print.
@article{8508486,
  abstract     = {Neurocysticercosis (NCC), Taenia solium larval infection of the brain, is an important cause of acquired seizures in endemic countries, which relate to number, location and degenerating cysts in the brain. Multicyst infections are common in endemic countries although single-cyst infection prevails in India. Single-cyst infections in an endemic country suggest a role for host immunity limiting the infection. This study examined ex vivo CD4(+) T cells and in vitro Th1 and Th2 cytokine responses to T.solium cyst antigens of peripheral blood mononuclear cells of healthy subjects from endemic and nonendemic regions and of single- and multicyst-infected patients for association with cyst burden of NCC. T.solium cyst antigens elicited a Th1 cytokine response in healthy subjects of T.solium-endemic and T.solium-non-endemic regions and those with single-cyst infections and a Th2 cytokine response from subjects with multicyst neurocysticercosis. Multicyst neurocysticercosis subjects also exhibited low levels of effector memory CD4(+) T cells. Th1 cytokine response of T.solium exposure and low infectious loads may aid in limiting cyst number. Th2 cytokines and low effector T cells may enable multiple-cyst infections to establish and persist.},
  author       = {Tharmalingam, J and Prabhakar, AT and Gangadaran, P and Dorny, Pierre and Vercruysse, Jozef and Geldhof, Peter and Rajshekhar, V and Alexander, M and Oommen, A},
  issn         = {0141-9838},
  journal      = {PARASITE IMMUNOLOGY},
  keywords     = {CD4(+) T cells,cellular immunity,India,neurocysticercosis,Taenia solium cyst antigens,SOLITARY CYSTICERCUS GRANULOMA,T-CELLS,INDIAN PATIENTS,PARASITE,CRASSICEPS,RESISTANCE,INFECTION,DISEASE,INTERLEUKIN-10,PROFILE},
  language     = {eng},
  number       = {10},
  pages        = {628--634},
  title        = {Host Th1/Th2 immune response to Taenia solium cyst antigens in relation to cyst burden of neurocysticercosis},
  url          = {http://dx.doi.org/10.1111/pim.12351},
  volume       = {38},
  year         = {2016},
}

Altmetric
View in Altmetric
Web of Science
Times cited: