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Geospatial and age-related patterns of Taenia solium taeniasis in the rural health zone of Kimpese, Democratic Republic of Congo

Joule Madinga, Iirezi Kanobana, Philippe Lukanu, Emmanuel Abatih, Sylvain Baloji, Sylvie Linsuke, Nicolas Praet, Serge Kapinga, Katja Polman, Pascal Lutumba, et al. (2017) ACTA TROPICA. 165. p.100-109
abstract
Background: Taenia solium infections are mostly endemic in less developed countries where poor hygiene conditions and free-range pig management favor their transmission. Knowledge on patterns of infections in both human and pig is crucial to design effective control strategies. The aim of this study was to assess the prevalence, risk factors and spatial distribution of taeniasis in a rural area of the Democratic Republic of Congo (DRC), in the prospect of upcoming control activities. Methods: A cross-sectional study was conducted in 24 villages of the health zone of Kimpese, Bas Congo Province. Individual and household characteristics, including geographical coordinates were recorded. Stool samples were collected from willing participants and analyzed using the copro-antigen enzyme linked immunosorbent assay (copro-Ag ELISA) for the detection of taeniasis. Blood samples were collected from pigs and analyzed using the B158/660 monoclonal antibody-based antigen ELISA (sero-Ag ELISA) to detect porcine cysticercosis. Logistic regression and multilevel analysis were applied to identify risk factors. Global clustering and spatial correlation of taeniasis and porcine cysticercosis were assessed using K functions. Local clusters of both infections were identified using the Kulldorff s scan statistic. Results: A total of 4751 participants above 5 years of age (median: 23 years; IQR: 11-41) were included. The overall proportion of taeniasis positivity was 23.4% (95% CI: 22.2-24.6), ranging from 1 to 60% between villages, with a significant between-household variance of 2.43 (SE = 0.29, p < 0.05). Taeniasis was significantly associated with age (p < 0.05) and the highest positivity was found in the 5-10 years age group (27.0% (95% CI: 24.4-29.7)). Overall, 45.6% (95% CI: 40.2-51) of sampled pigs were sero-positive. The K functions revealed a significant overall clustering of human and pig infections but no spatial dependence between them. Two significant clusters of taeniasis (p<0.001; n = 276 and n = 9) and one cluster of porcine cysticercosis (p<0.001; n = 24) were found. Conclusion: This study confirms high endemicity and geographical dispersal of taeniasis in the study area. The role of age in taeniasis patterns and significant spatial clusters of both taeniasis and porcine cysticercosis were evidenced, though no spatial correlation was found between human and pig infections. Urgent control activities are needed for this endemic area.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PORCINE CYSTICERCOSIS, TAPEWORM CARRIERS, RISK-FACTORS, GUATEMALAN, COMMUNITIES, NORTHERN TANZANIA, EASTERN ZAMBIA, PREVALENCE, PIGS, EPIDEMIOLOGY, INFECTIONS, Taeniasis, Porcine cysticercosis, Epidemiology, Spatial clustering, Democratic republic of Congo
journal title
ACTA TROPICA
Acta Trop.
volume
165
pages
100 - 109
Web of Science type
Article
Web of Science id
000390973400013
ISSN
0001-706X
1873-6254
DOI
10.1016/j.actatropica.2016.03.013
language
English
UGent publication?
no
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8508437
handle
http://hdl.handle.net/1854/LU-8508437
date created
2017-02-09 09:15:08
date last changed
2017-03-09 15:13:58
@article{8508437,
  abstract     = {Background: Taenia solium infections are mostly endemic in less developed countries where poor hygiene conditions and free-range pig management favor their transmission. Knowledge on patterns of infections in both human and pig is crucial to design effective control strategies. The aim of this study was to assess the prevalence, risk factors and spatial distribution of taeniasis in a rural area of the Democratic Republic of Congo (DRC), in the prospect of upcoming control activities. 
Methods: A cross-sectional study was conducted in 24 villages of the health zone of Kimpese, Bas Congo Province. Individual and household characteristics, including geographical coordinates were recorded. Stool samples were collected from willing participants and analyzed using the copro-antigen enzyme linked immunosorbent assay (copro-Ag ELISA) for the detection of taeniasis. Blood samples were collected from pigs and analyzed using the B158/660 monoclonal antibody-based antigen ELISA (sero-Ag ELISA) to detect porcine cysticercosis. Logistic regression and multilevel analysis were applied to identify risk factors. Global clustering and spatial correlation of taeniasis and porcine cysticercosis were assessed using K functions. Local clusters of both infections were identified using the Kulldorff s scan statistic. 
Results: A total of 4751 participants above 5 years of age (median: 23 years; IQR: 11-41) were included. The overall proportion of taeniasis positivity was 23.4\% (95\% CI: 22.2-24.6), ranging from 1 to 60\% between villages, with a significant between-household variance of 2.43 (SE = 0.29, p {\textlangle} 0.05). Taeniasis was significantly associated with age (p {\textlangle} 0.05) and the highest positivity was found in the 5-10 years age group (27.0\% (95\% CI: 24.4-29.7)). Overall, 45.6\% (95\% CI: 40.2-51) of sampled pigs were sero-positive. The K functions revealed a significant overall clustering of human and pig infections but no spatial dependence between them. Two significant clusters of taeniasis (p{\textlangle}0.001; n = 276 and n = 9) and one cluster of porcine cysticercosis (p{\textlangle}0.001; n = 24) were found. 
Conclusion: This study confirms high endemicity and geographical dispersal of taeniasis in the study area. The role of age in taeniasis patterns and significant spatial clusters of both taeniasis and porcine cysticercosis were evidenced, though no spatial correlation was found between human and pig infections. Urgent control activities are needed for this endemic area.},
  author       = {Madinga, Joule and Kanobana, Iirezi and Lukanu, Philippe and Abatih, Emmanuel and Baloji, Sylvain and Linsuke, Sylvie and Praet, Nicolas and Kapinga, Serge and Polman, Katja and Lutumba, Pascal and Speybroeck, Niko and Dorny, Pierre and Harrison, Wendy and Gabri{\"e}l, Sarah},
  issn         = {0001-706X},
  journal      = {ACTA TROPICA},
  keyword      = {PORCINE CYSTICERCOSIS,TAPEWORM CARRIERS,RISK-FACTORS,GUATEMALAN,COMMUNITIES,NORTHERN TANZANIA,EASTERN ZAMBIA,PREVALENCE,PIGS,EPIDEMIOLOGY,INFECTIONS,Taeniasis,Porcine cysticercosis,Epidemiology,Spatial clustering,Democratic republic of Congo},
  language     = {eng},
  pages        = {100--109},
  title        = {Geospatial and age-related patterns of Taenia solium taeniasis in the rural health zone of Kimpese, Democratic Republic of Congo},
  url          = {http://dx.doi.org/10.1016/j.actatropica.2016.03.013},
  volume       = {165},
  year         = {2017},
}

Chicago
Madinga, Joule, Iirezi Kanobana, Philippe Lukanu, Emmanuel Abatih, Sylvain Baloji, Sylvie Linsuke, Nicolas Praet, et al. 2017. “Geospatial and Age-related Patterns of Taenia Solium Taeniasis in the Rural Health Zone of Kimpese, Democratic Republic of Congo.” Acta Tropica 165: 100–109.
APA
Madinga, J., Kanobana, I., Lukanu, P., Abatih, E., Baloji, S., Linsuke, S., Praet, N., et al. (2017). Geospatial and age-related patterns of Taenia solium taeniasis in the rural health zone of Kimpese, Democratic Republic of Congo. ACTA TROPICA, 165, 100–109.
Vancouver
1.
Madinga J, Kanobana I, Lukanu P, Abatih E, Baloji S, Linsuke S, et al. Geospatial and age-related patterns of Taenia solium taeniasis in the rural health zone of Kimpese, Democratic Republic of Congo. ACTA TROPICA. 2017;165:100–9.
MLA
Madinga, Joule, Iirezi Kanobana, Philippe Lukanu, et al. “Geospatial and Age-related Patterns of Taenia Solium Taeniasis in the Rural Health Zone of Kimpese, Democratic Republic of Congo.” ACTA TROPICA 165 (2017): 100–109. Print.