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Endothelial response to glucocorticoids in inflammatory diseases

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Abstract
The endothelium plays a crucial role in inflammation. A balanced control of inflammation requires the action of glucocorticoids (GCs), steroidal hormones with potent cell-specific anti-inflammatory properties. Besides the classic anti-inflammatory effects of GCs on leukocytes, recent studies confirm that endothelial cells also represent an important target for GCs. GCs regulate different aspects of endothelial physiology including expression of adhesion molecules, production of pro-inflammatory cytokines and chemokines, and maintenance of endothelial barrier integrity. However, the regulation of endothelial GC sensitivity remains incompletely understood. In this review, we specifically examine the endothelial response to GCs in various inflammatory diseases ranging from multiple sclerosis, stroke, sepsis, and vasculitis to atherosclerosis. Shedding more light on the cross talk between GCs and endothelium will help to improve existing therapeutic strategies and develop new therapies better tailored to the needs of patients.
Keywords
endothelium, glucocorticoids, glucocorticoid resistance, inflammation, cytokines, tight junctions, adhesion molecules, BLOOD-BRAIN-BARRIER, NF-KAPPA-B, GIANT-CELL ARTERITIS, E-SELECTIN EXPRESSION, NECROSIS-FACTOR-ALPHA, ANTIBODY-ASSOCIATED VASCULITIS, MESSENGER-RNA STABILITY, TIGHT JUNCTION PROTEINS, LARGE-VESSEL VASCULITIS, VE-CADHERIN EXPRESSION

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Chicago
Zielińska, Karolina A, Laura Van Moortel, Ghislain Opdenakker, Karolien De Bosscher, and Philippe E Van den Steen. 2016. “Endothelial Response to Glucocorticoids in Inflammatory Diseases.” Frontiers in Immunology 7.
APA
Zielińska, K. A., Van Moortel, L., Opdenakker, G., De Bosscher, K., & Van den Steen, P. E. (2016). Endothelial response to glucocorticoids in inflammatory diseases. FRONTIERS IN IMMUNOLOGY, 7.
Vancouver
1.
Zielińska KA, Van Moortel L, Opdenakker G, De Bosscher K, Van den Steen PE. Endothelial response to glucocorticoids in inflammatory diseases. FRONTIERS IN IMMUNOLOGY. 2016;7.
MLA
Zielińska, Karolina A, Laura Van Moortel, Ghislain Opdenakker, et al. “Endothelial Response to Glucocorticoids in Inflammatory Diseases.” FRONTIERS IN IMMUNOLOGY 7 (2016): n. pag. Print.
@article{8507882,
  abstract     = {The endothelium plays a crucial role in inflammation. A balanced control of inflammation requires the action of glucocorticoids (GCs), steroidal hormones with potent cell-specific anti-inflammatory properties. Besides the classic anti-inflammatory effects of GCs on leukocytes, recent studies confirm that endothelial cells also represent an important target for GCs. GCs regulate different aspects of endothelial physiology including expression of adhesion molecules, production of pro-inflammatory cytokines and chemokines, and maintenance of endothelial barrier integrity. However, the regulation of endothelial GC sensitivity remains incompletely understood. In this review, we specifically examine the endothelial response to GCs in various inflammatory diseases ranging from multiple sclerosis, stroke, sepsis, and vasculitis to atherosclerosis. Shedding more light on the cross talk between GCs and endothelium will help to improve existing therapeutic strategies and develop new therapies better tailored to the needs of patients.},
  articleno    = {592},
  author       = {Zieli\'{n}ska, Karolina A and Van Moortel, Laura and Opdenakker, Ghislain and De Bosscher, Karolien and Van den Steen, Philippe E},
  issn         = {1664-3224},
  journal      = {FRONTIERS IN IMMUNOLOGY},
  keyword      = {endothelium,glucocorticoids,glucocorticoid resistance,inflammation,cytokines,tight junctions,adhesion molecules,BLOOD-BRAIN-BARRIER,NF-KAPPA-B,GIANT-CELL ARTERITIS,E-SELECTIN EXPRESSION,NECROSIS-FACTOR-ALPHA,ANTIBODY-ASSOCIATED VASCULITIS,MESSENGER-RNA STABILITY,TIGHT JUNCTION PROTEINS,LARGE-VESSEL VASCULITIS,VE-CADHERIN EXPRESSION},
  language     = {eng},
  pages        = {20},
  title        = {Endothelial response to glucocorticoids in inflammatory diseases},
  url          = {http://dx.doi.org/10.3389/fimmu.2016.00592},
  volume       = {7},
  year         = {2016},
}

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