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Randomized prospective study of the use of anti-inflammatory drops after selective laser trabeculoplasty

(2017) JOURNAL OF GLAUCOMA . 26(2). p.22-29
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Abstract
Purpose: Evaluating the use of Indomethacin, Dexamethasone, and no anti-inflammatory treatment immediately after selective laser trabeculoplasty (SLT). Materials and Methods: Prospective randomized clinical trial of 132 eyes. Both eyes of the patient underwent SLT. One of the eyes was treated with Indomethacin 0.1% or Dexamethasone 0.1% 3 times daily for 1 week; the other eye did not receive any antiinflammatory treatment. Intraocular pressure (IOP) and inflammatory parameters were recorded at 1 hour, 1 week, 1, 3, and 6 months. Results: Cells in the anterior chamber were present in 57% to 71% of the patients after 1 hour. About 16% to 37% of the patients reported pain/discomfort after 1 hour. Redness was present before SLT in 29% to 34% of the patients, probably due to antiglaucoma medication. After 1 hour, the amount of redness recorded raised to 32% to 42%, but the amount of patients with redness returned to pretreatment levels after 1 week. An IOP peak of > 5mm Hg above baseline IOP 1 hour after laser was present in 3% to 9% of the patients. IOP lowered 11% to 21% compared with IOP at baseline. The number of medications needed changed from 1.45 to 1.49 before, to 0.23 to 0.45 six months after SLT. No differential effects based on the kind of anti-inflammatory treatment or no treatment were found for any of the parameters. Conclusions: SLT induces little inflammation: anti-inflammatory drops do not make a significant difference in pain, redness, cells in anterior chamber, or peak IOP following SLT. The IOP-lowering effect of the SLT is not influenced by the use of Indomethacin or Dexamethasone.
Keywords
selective laser trabeculoplasty, anti-inflammatory drops, side effects of SLT, glaucoma, use of steroids

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Citation

Please use this url to cite or link to this publication:

Chicago
De Keyser, Myrjam, Maya De Belder, and Veva De Groot. 2017. “Randomized Prospective Study of the Use of Anti-inflammatory Drops After Selective Laser Trabeculoplasty.” Journal of Glaucoma  26 (2): 22–29.
APA
De Keyser, M., De Belder, M., & De Groot, V. (2017). Randomized prospective study of the use of anti-inflammatory drops after selective laser trabeculoplasty. JOURNAL OF GLAUCOMA  , 26(2), 22–29.
Vancouver
1.
De Keyser M, De Belder M, De Groot V. Randomized prospective study of the use of anti-inflammatory drops after selective laser trabeculoplasty. JOURNAL OF GLAUCOMA  . Ovid Technologies (Wolters Kluwer Health); 2017;26(2):22–9.
MLA
De Keyser, Myrjam, Maya De Belder, and Veva De Groot. “Randomized Prospective Study of the Use of Anti-inflammatory Drops After Selective Laser Trabeculoplasty.” JOURNAL OF GLAUCOMA  26.2 (2017): 22–29. Print.
@article{8507751,
  abstract     = {Purpose: Evaluating the use of Indomethacin, Dexamethasone, and no anti-inflammatory treatment immediately after selective laser trabeculoplasty (SLT). 

Materials and Methods: Prospective randomized clinical trial of 132 eyes. Both eyes of the patient underwent SLT. One of the eyes was treated with Indomethacin 0.1\% or Dexamethasone 0.1\% 3 times daily for 1 week; the other eye did not receive any antiinflammatory treatment. Intraocular pressure (IOP) and inflammatory parameters were recorded at 1 hour, 1 week, 1, 3, and 6 months. 

Results: Cells in the anterior chamber were present in 57\% to 71\% of the patients after 1 hour. About 16\% to 37\% of the patients reported pain/discomfort after 1 hour. Redness was present before SLT in 29\% to 34\% of the patients, probably due to antiglaucoma medication. After 1 hour, the amount of redness recorded raised to 32\% to 42\%, but the amount of patients with redness returned to pretreatment levels after 1 week. An IOP peak of {\textrangle} 5mm Hg above baseline IOP 1 hour after laser was present in 3\% to 9\% of the patients. IOP lowered 11\% to 21\% compared with IOP at baseline. The number of medications needed changed from 1.45 to 1.49 before, to 0.23 to 0.45 six months after SLT. No differential effects based on the kind of anti-inflammatory treatment or no treatment were found for any of the parameters. 

Conclusions: SLT induces little inflammation: anti-inflammatory drops do not make a significant difference in pain, redness, cells in anterior chamber, or peak IOP following SLT. The IOP-lowering effect of the SLT is not influenced by the use of Indomethacin or Dexamethasone.},
  author       = {De Keyser, Myrjam and De Belder, Maya and De Groot, Veva},
  issn         = {1057-0829},
  journal      = {JOURNAL OF GLAUCOMA                            },
  keyword      = {selective laser trabeculoplasty,anti-inflammatory drops,side effects of SLT,glaucoma,use of steroids},
  language     = {eng},
  number       = {2},
  pages        = {22--29},
  publisher    = {Ovid Technologies (Wolters Kluwer Health)},
  title        = {Randomized prospective study of the use of anti-inflammatory drops after selective laser trabeculoplasty},
  url          = {http://dx.doi.org/10.1097/ijg.0000000000000522},
  volume       = {26},
  year         = {2017},
}

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