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Common variants at five new loci associated with early-onset inflammatory bowel disease

(2009) NATURE GENETICS. 41(12). p.1335-U107
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Abstract
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD1. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD.
Keywords
MULTIPLE, HISTORY, AUTOPHAGY, CONTRIBUTE, EXPRESSION, GENE, SEQUENCE VARIANTS, SUSCEPTIBILITY LOCI, GENOME-WIDE ASSOCIATION, CROHNS-DISEASE

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Chicago
Imielinski, M, RN Baldassano, A Griffiths, RK Russell, V Annese, M Dubinsky, S Kugathasan, et al. 2009. “Common Variants at Five New Loci Associated with Early-onset Inflammatory Bowel Disease.” Nature Genetics 41 (12): 1335–U107.
APA
Imielinski, M., Baldassano, R., Griffiths, A., Russell, R., Annese, V., Dubinsky, M., Kugathasan, S., et al. (2009). Common variants at five new loci associated with early-onset inflammatory bowel disease. NATURE GENETICS, 41(12), 1335–U107.
Vancouver
1.
Imielinski M, Baldassano R, Griffiths A, Russell R, Annese V, Dubinsky M, et al. Common variants at five new loci associated with early-onset inflammatory bowel disease. NATURE GENETICS. NEW YORK: NATURE PUBLISHING GROUP; 2009;41(12):1335–U107.
MLA
Imielinski, M, RN Baldassano, A Griffiths, et al. “Common Variants at Five New Loci Associated with Early-onset Inflammatory Bowel Disease.” NATURE GENETICS 41.12 (2009): 1335–U107. Print.
@article{850759,
  abstract     = {The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD1. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD.},
  author       = {Imielinski, M and Baldassano, RN and Griffiths, A and Russell, RK and Annese, V and Dubinsky, M and Kugathasan, S and Bradfield, JP and Walters, TD and Sleiman, P and Kim, CE and Muise, A and Wang, K and Glessner, JT and Saeed, S and Zhang, HT and Frackelton, EC and Hou, CP and Flory, JH and Otieno, G and Chiavacci, RM and Grundmeier, R and Castro, M and Latiano, A and Dallapiccola, B and Stempak, J and Abrams, DJ and Taylor, K and McGovern, D and Heyman, MB and Ferry, GD and Kirschner, B and Lee, J and Essers, J and Grand, R and Stephens, M and Levine, A and Piccoli, D and Van Limbergen, J and Cucchiara, S and Monos, DS and Guthery, SL and Denson, L and Wilson, DC and Grant, SFA and Daly, M and Silverberg, MS and Satsangi, J and Hakonarson, H and Laukens, Debby and De Vos, Martine},
  issn         = {1061-4036},
  journal      = {NATURE GENETICS},
  keyword      = {MULTIPLE,HISTORY,AUTOPHAGY,CONTRIBUTE,EXPRESSION,GENE,SEQUENCE VARIANTS,SUSCEPTIBILITY LOCI,GENOME-WIDE ASSOCIATION,CROHNS-DISEASE},
  language     = {eng},
  number       = {12},
  pages        = {1335--U107},
  publisher    = {NATURE PUBLISHING GROUP},
  title        = {Common variants at five new loci associated with early-onset inflammatory bowel disease},
  url          = {http://dx.doi.org/10.1038/ng.489},
  volume       = {41},
  year         = {2009},
}

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