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The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity

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Abstract
Various steady state and inflamed tissues have been shown to contain a heterogeneous DC population consisting of developmentally distinct subsets, including cDC1s, cDC2s and monocyte-derived DCs, displaying differential functional specializations. The identification of functionally distinct tumour-associated DC (TADC) subpopulations could prove essential for the understanding of basic TADC biology and for envisaging targeted immunotherapies. We demonstrate that multiple mouse tumours as well as human tumours harbour ontogenically discrete TADC subsets. Monocyte-derived TADCs are prominent in tumour antigen uptake, but lack strong T-cell stimulatory capacity due to NO-mediated immunosuppression. Pre-cDC-derived TADCs have lymph node migratory potential, whereby cDC1s efficiently activate CD8(+) Tcells and cDC2s induce Th17 cells. Mice vaccinated with cDC2s displayed a reduced tumour growth accompanied by a reprogramming of pro-tumoural TAMs and a reduction of MDSCs, while cDC1 vaccination strongly induces anti-tumour CTLs. Our data might prove important for therapeutic interventions targeted at specific TADC subsets or their precursors.
Keywords
CYTOKINE GM-CSF, T-CELLS, INTRATUMORAL DELIVERY, CANCER-IMMUNOTHERAPY, STEADY-STATE, IN-VIVO, RESPONSES, SUBSETS, MACROPHAGES, DIFFERENTIATION

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MLA
Laoui, Damya et al. “The Tumour Microenvironment Harbours Ontogenically Distinct Dendritic Cell Populations with Opposing Effects on Tumour Immunity.” NATURE COMMUNICATIONS 7 (2016): n. pag. Print.
APA
Laoui, D., Keirsse, J., Morias, Y., Van Overmeire, E., Geeraerts, X., Elkrim, Y., Kiss, M., et al. (2016). The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity. NATURE COMMUNICATIONS, 7.
Chicago author-date
Laoui, Damya, Jiri Keirsse, Yannick Morias, Eva Van Overmeire, Xenia Geeraerts, Yvon Elkrim, Mate Kiss, et al. 2016. “The Tumour Microenvironment Harbours Ontogenically Distinct Dendritic Cell Populations with Opposing Effects on Tumour Immunity.” Nature Communications 7.
Chicago author-date (all authors)
Laoui, Damya, Jiri Keirsse, Yannick Morias, Eva Van Overmeire, Xenia Geeraerts, Yvon Elkrim, Mate Kiss, Evangelia Bolli, Qods Lahmar, Dorine Sichien, Jens Serneels, Charlotte Scott, Louis Boon, Patrick De Baetselier, Massimiliano Mazzone, Martin Guilliams, and Jo A Van Ginderachter. 2016. “The Tumour Microenvironment Harbours Ontogenically Distinct Dendritic Cell Populations with Opposing Effects on Tumour Immunity.” Nature Communications 7.
Vancouver
1.
Laoui D, Keirsse J, Morias Y, Van Overmeire E, Geeraerts X, Elkrim Y, et al. The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity. NATURE COMMUNICATIONS. 2016;7.
IEEE
[1]
D. Laoui et al., “The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity,” NATURE COMMUNICATIONS, vol. 7, 2016.
@article{8507540,
  abstract     = {Various steady state and inflamed tissues have been shown to contain a heterogeneous DC population consisting of developmentally distinct subsets, including cDC1s, cDC2s and monocyte-derived DCs, displaying differential functional specializations. The identification of functionally distinct tumour-associated DC (TADC) subpopulations could prove essential for the understanding of basic TADC biology and for envisaging targeted immunotherapies. We demonstrate that multiple mouse tumours as well as human tumours harbour ontogenically discrete TADC subsets. Monocyte-derived TADCs are prominent in tumour antigen uptake, but lack strong T-cell stimulatory capacity due to NO-mediated immunosuppression. Pre-cDC-derived TADCs have lymph node migratory potential, whereby cDC1s efficiently activate CD8(+) Tcells and cDC2s induce Th17 cells. Mice vaccinated with cDC2s displayed a reduced tumour growth accompanied by a reprogramming of pro-tumoural TAMs and a reduction of MDSCs, while cDC1 vaccination strongly induces anti-tumour CTLs. Our data might prove important for therapeutic interventions targeted at specific TADC subsets or their precursors.},
  articleno    = {13720},
  author       = {Laoui, Damya and Keirsse, Jiri and Morias, Yannick and Van Overmeire, Eva and Geeraerts, Xenia and Elkrim, Yvon and Kiss, Mate and Bolli, Evangelia and Lahmar, Qods and Sichien, Dorine and Serneels, Jens and Scott, Charlotte and Boon, Louis and De Baetselier, Patrick and Mazzone, Massimiliano and Guilliams, Martin and Van Ginderachter, Jo A},
  issn         = {2041-1723},
  journal      = {NATURE COMMUNICATIONS},
  keywords     = {CYTOKINE GM-CSF,T-CELLS,INTRATUMORAL DELIVERY,CANCER-IMMUNOTHERAPY,STEADY-STATE,IN-VIVO,RESPONSES,SUBSETS,MACROPHAGES,DIFFERENTIATION},
  language     = {eng},
  pages        = {17},
  title        = {The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity},
  url          = {http://dx.doi.org/10.1038/ncomms13720},
  volume       = {7},
  year         = {2016},
}

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