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Uncertainty of fast biological radiation dose assessment for emergency response scenarios

Author
Organization
Project
RENEB (Realizing the European Network in Biodosimetry)
Abstract
Purpose: Reliable dose estimation is an important factor in appropriate dosimetric triage categorization of exposed individuals to support radiation emergency response. Materials and methods: Following work done under the EU FP7 MULTIBIODOSE and RENEB projects, formal methods for defining uncertainties on biological dose estimates are compared using simulated and real data from recent exercises. Results: The results demonstrate that a Bayesian method of uncertainty assessment is the most appropriate, even in the absence of detailed prior information. The relative accuracy and relevance of techniques for calculating uncertainty and combining assay results to produce single dose and uncertainty estimates is further discussed. Conclusions: Finally, it is demonstrated that whatever uncertainty estimation method is employed, ignoring the uncertainty on fast dose assessments can have an important impact on rapid biodosimetric categorization.
Keywords
Biodosimetry, retrospective dosimetry, radiation, triage screening, uncertainty, CHROMOSOME-ABERRATION DATA, DICENTRIC CHROMOSOMES, BIODOSIMETRY, RENEB, LABORATORIES, VALIDATION, PURPOSES, NETWORK, ASSAY

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Citation

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Chicago
Ainsbury, Elizabeth A, Manuel Higueras, Pedro Puig, Jochen Einbeck, Daniel Samaga, Joan Francesc Barquinero, Lleonard Barrios, et al. 2017. “Uncertainty of Fast Biological Radiation Dose Assessment for Emergency Response Scenarios.” International Journal of Radiation Biology 93 (1): 127–135.
APA
Ainsbury, E. A., Higueras, M., Puig, P., Einbeck, J., Samaga, D., Barquinero, J. F., Barrios, L., et al. (2017). Uncertainty of fast biological radiation dose assessment for emergency response scenarios. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 93(1), 127–135.
Vancouver
1.
Ainsbury EA, Higueras M, Puig P, Einbeck J, Samaga D, Barquinero JF, et al. Uncertainty of fast biological radiation dose assessment for emergency response scenarios. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2017;93(1):127–35.
MLA
Ainsbury, Elizabeth A, Manuel Higueras, Pedro Puig, et al. “Uncertainty of Fast Biological Radiation Dose Assessment for Emergency Response Scenarios.” INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 93.1 (2017): 127–135. Print.
@article{8507469,
  abstract     = {Purpose: Reliable dose estimation is an important factor in appropriate dosimetric triage categorization of exposed individuals to support radiation emergency response.
Materials and methods: Following work done under the EU FP7 MULTIBIODOSE and RENEB projects, formal methods for defining uncertainties on biological dose estimates are compared using simulated and real data from recent exercises.
Results: The results demonstrate that a Bayesian method of uncertainty assessment is the most appropriate, even in the absence of detailed prior information. The relative accuracy and relevance of techniques for calculating uncertainty and combining assay results to produce single dose and uncertainty estimates is further discussed.
Conclusions: Finally, it is demonstrated that whatever uncertainty estimation method is employed, ignoring the uncertainty on fast dose assessments can have an important impact on rapid biodosimetric categorization.},
  author       = {Ainsbury, Elizabeth A and Higueras, Manuel and Puig, Pedro and Einbeck, Jochen and Samaga, Daniel and Barquinero, Joan Francesc and Barrios, Lleonard and Brzozowska, Beata and Fattibene, Paola and Gregoire, Eric and Jaworska, Alicja and Lloyd, David and Oestreicher, Ursula and Romm, Horst and Rothkamm, Kai and Roy, Laurence and Sommer, Sylwester and Terzoudi, Georgia and Thierens, Hubert and Trompier, Francois and Vral, Anne and Woda, Clemens},
  issn         = {0955-3002},
  journal      = {INTERNATIONAL JOURNAL OF RADIATION BIOLOGY},
  keyword      = {Biodosimetry,retrospective dosimetry,radiation,triage screening,uncertainty,CHROMOSOME-ABERRATION DATA,DICENTRIC CHROMOSOMES,BIODOSIMETRY,RENEB,LABORATORIES,VALIDATION,PURPOSES,NETWORK,ASSAY},
  language     = {eng},
  number       = {1},
  pages        = {127--135},
  title        = {Uncertainty of fast biological radiation dose assessment for emergency response scenarios},
  url          = {http://dx.doi.org/10.1080/09553002.2016.1227106},
  volume       = {93},
  year         = {2017},
}

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