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RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA)

Ursula Oestreicher, Daniel Samaga, Elizabeth Ainsbury, Ana Catarina Antunes, Ans Baeyens UGent, Leonardo Barrios, Christina Beinke, Philip Beukes, William F. Blakely, Alexandra Cucu, et al. (2017) INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 93(1). p.20-29
abstract
Purpose: Two quality controlled inter-laboratory exercises were organized within the EU project ‘Realizing the European Network of Biodosimetry (RENEB)’ to further optimize the dicentric chromosome assay (DCA) and to identify needs for training and harmonization activities within the RENEB network. Materials and methods: The general study design included blood shipment, sample processing, analysis of chromosome aberrations and radiation dose assessment. After manual scoring of dicentric chromosomes in different cell numbers dose estimations and corresponding 95% confidence intervals were submitted by the participants. Results: The shipment of blood samples to the partners in the European Community (EU) were performed successfully. Outside the EU unacceptable delays occurred. The results of the dose estimation demonstrate a very successful classification of the blood samples in medically relevant groups. In comparison to the 1st exercise the 2nd intercomparison showed an improvement in the accuracy of dose estimations especially for the high dose point. Conclusions: In case of a large-scale radiological incident, the pooling of ressources by networks can enhance the rapid classification of individuals in medically relevant treatment groups based on the DCA. The performance of the RENEB network as a whole has clearly benefited from harmonization processes and specific training activities for the network partners.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Biological dosimetry, dicentric chromosomes, intercomparison, network, RENEB, RADIATION BIODOSIMETRY, BIOLOGICAL DOSIMETRY, EUROPEAN NETWORK, TRIAGE, CASUALTIES, MODE
journal title
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Int. J. Radiat. Biol.
volume
93
issue
1
pages
20 - 29
Web of Science type
Article
Web of Science id
000392891400004
ISSN
0955-3002
DOI
10.1080/09553002.2016.1233370
project
RENEB (Realizing the European Network in Biodosimetry)
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8507326
handle
http://hdl.handle.net/1854/LU-8507326
date created
2017-02-03 10:56:30
date last changed
2017-03-09 11:34:26
@article{8507326,
  abstract     = {Purpose: Two quality controlled inter-laboratory exercises were organized within the EU project {\textquoteleft}Realizing the European Network of Biodosimetry (RENEB){\textquoteright} to further optimize the dicentric chromosome assay (DCA) and to identify needs for training and harmonization activities within the RENEB network.
Materials and methods: The general study design included blood shipment, sample processing, analysis of chromosome aberrations and radiation dose assessment. After manual scoring of dicentric chromosomes in different cell numbers dose estimations and corresponding 95\% confidence intervals were submitted by the participants.
Results: The shipment of blood samples to the partners in the European Community (EU) were performed successfully. Outside the EU unacceptable delays occurred. The results of the dose estimation demonstrate a very successful classification of the blood samples in medically relevant groups. In comparison to the 1st exercise the 2nd intercomparison showed an improvement in the accuracy of dose estimations especially for the high dose point.
Conclusions: In case of a large-scale radiological incident, the pooling of ressources by networks can enhance the rapid classification of individuals in medically relevant treatment groups based on the DCA. The performance of the RENEB network as a whole has clearly benefited from harmonization processes and specific training activities for the network partners.},
  author       = {Oestreicher, Ursula and Samaga, Daniel and Ainsbury, Elizabeth and Antunes, Ana Catarina and Baeyens, Ans and Barrios, Leonardo and Beinke, Christina and Beukes, Philip and Blakely, William F. and Cucu, Alexandra and De Amicis, Andrea and Depuydt, Julie and De Sanctis, Stefania and Di Giorgio, Marina and Dobos, Katalin and Dominguez, Inmaculada and Duy, Pham Ngoc and Espinoza, Marco E. and Flegal, Farrah N. and Figel, Markus and Garcia, Omar and Monteiro Gil, Oct{\'a}via and Gregoire, Eric and Guerrero-Carbajal, C. and G{\"u}\c{c}l{\"u}, \.{I}nci and Hadjidekova, Valeria and Hande, Prakash and Kulka, Ulrike and Lemon, Jennifer and Lindholm, Carita and Lista, Florigio and Lumniczky, Katalin and Martinez-Lopez, Wilner and Maznyk, Nataliya and Meschini, Roberta and M{\textquoteright}kacher, Radia and Montoro, Alegria and Moquet, Jayne and Moreno, Mercedes and Noditi, Mihaela and Pajic, Jelena and Radl, Anal{\'i}a and Ricoul, Michelle and Romm, Horst and Roy, Laurence and Sabatier, Laure and Sebasti{\`a}, Natividad and Slabbert, Jacobus and Sommer, Sylwester and Stuck Oliveira, Monica and Subramanian, Uma and Suto, Yumiko and Que, Tran and Testa, Antonella and Terzoudi, Georgia and Vral, Anne and Wilkins, Ruth and Yanti, LusiYanti and Zafiropoulos, Demetre and Wojcik, Andrzej},
  issn         = {0955-3002},
  journal      = {INTERNATIONAL JOURNAL OF RADIATION BIOLOGY},
  keyword      = {Biological dosimetry,dicentric chromosomes,intercomparison,network,RENEB,RADIATION BIODOSIMETRY,BIOLOGICAL DOSIMETRY,EUROPEAN NETWORK,TRIAGE,CASUALTIES,MODE},
  language     = {eng},
  number       = {1},
  pages        = {20--29},
  title        = {RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA)},
  url          = {http://dx.doi.org/10.1080/09553002.2016.1233370},
  volume       = {93},
  year         = {2017},
}

Chicago
Oestreicher, Ursula, Daniel Samaga, Elizabeth Ainsbury, Ana Catarina Antunes, Ans Baeyens, Leonardo Barrios, Christina Beinke, et al. 2017. “RENEB Intercomparisons Applying the Conventional Dicentric Chromosome Assay (DCA).” International Journal of Radiation Biology 93 (1): 20–29.
APA
Oestreicher, U., Samaga, D., Ainsbury, E., Antunes, A. C., Baeyens, A., Barrios, L., Beinke, C., et al. (2017). RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA). INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 93(1), 20–29.
Vancouver
1.
Oestreicher U, Samaga D, Ainsbury E, Antunes AC, Baeyens A, Barrios L, et al. RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA). INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2017;93(1):20–9.
MLA
Oestreicher, Ursula, Daniel Samaga, Elizabeth Ainsbury, et al. “RENEB Intercomparisons Applying the Conventional Dicentric Chromosome Assay (DCA).” INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 93.1 (2017): 20–29. Print.