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RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA)

Author
Organization
Project
  • RENEB (Realizing the European network in Biodosimetry (RENEB))
Abstract
Purpose: Two quality controlled inter-laboratory exercises were organized within the EU project ‘Realizing the European Network of Biodosimetry (RENEB)’ to further optimize the dicentric chromosome assay (DCA) and to identify needs for training and harmonization activities within the RENEB network. Materials and methods: The general study design included blood shipment, sample processing, analysis of chromosome aberrations and radiation dose assessment. After manual scoring of dicentric chromosomes in different cell numbers dose estimations and corresponding 95% confidence intervals were submitted by the participants. Results: The shipment of blood samples to the partners in the European Community (EU) were performed successfully. Outside the EU unacceptable delays occurred. The results of the dose estimation demonstrate a very successful classification of the blood samples in medically relevant groups. In comparison to the 1st exercise the 2nd intercomparison showed an improvement in the accuracy of dose estimations especially for the high dose point. Conclusions: In case of a large-scale radiological incident, the pooling of ressources by networks can enhance the rapid classification of individuals in medically relevant treatment groups based on the DCA. The performance of the RENEB network as a whole has clearly benefited from harmonization processes and specific training activities for the network partners.
Keywords
Biological dosimetry, dicentric chromosomes, intercomparison, network, RENEB, RADIATION BIODOSIMETRY, BIOLOGICAL DOSIMETRY, EUROPEAN NETWORK, TRIAGE, CASUALTIES, MODE

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Citation

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MLA
Oestreicher, Ursula et al. “RENEB Intercomparisons Applying the Conventional Dicentric Chromosome Assay (DCA).” INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 93.1 (2017): 20–29. Print.
APA
Oestreicher, U., Samaga, D., Ainsbury, E., Antunes, A. C., Baeyens, A., Barrios, L., Beinke, C., et al. (2017). RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA). INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 93(1), 20–29.
Chicago author-date
Oestreicher, Ursula, Daniel Samaga, Elizabeth Ainsbury, Ana Catarina Antunes, Ans Baeyens, Leonardo Barrios, Christina Beinke, et al. 2017. “RENEB Intercomparisons Applying the Conventional Dicentric Chromosome Assay (DCA).” International Journal of Radiation Biology 93 (1): 20–29.
Chicago author-date (all authors)
Oestreicher, Ursula, Daniel Samaga, Elizabeth Ainsbury, Ana Catarina Antunes, Ans Baeyens, Leonardo Barrios, Christina Beinke, Philip Beukes, William F. Blakely, Alexandra Cucu, Andrea De Amicis, Julie Depuydt, Stefania De Sanctis, Marina Di Giorgio, Katalin Dobos, Inmaculada Dominguez, Pham Ngoc Duy, Marco E. Espinoza, Farrah N. Flegal, Markus Figel, Omar Garcia, Octávia Monteiro Gil, Eric Gregoire, C. Guerrero-Carbajal, İnci Güçlü, Valeria Hadjidekova, Prakash Hande, Ulrike Kulka, Jennifer Lemon, Carita Lindholm, Florigio Lista, Katalin Lumniczky, Wilner Martinez-Lopez, Nataliya Maznyk, Roberta Meschini, Radia M’kacher, Alegria Montoro, Jayne Moquet, Mercedes Moreno, Mihaela Noditi, Jelena Pajic, Analía Radl, Michelle Ricoul, Horst Romm, Laurence Roy, Laure Sabatier, Natividad Sebastià, Jacobus Slabbert, Sylwester Sommer, Monica Stuck Oliveira, Uma Subramanian, Yumiko Suto, Tran Que, Antonella Testa, Georgia Terzoudi, Anne Vral, Ruth Wilkins, LusiYanti Yanti, Demetre Zafiropoulos, and Andrzej Wojcik. 2017. “RENEB Intercomparisons Applying the Conventional Dicentric Chromosome Assay (DCA).” International Journal of Radiation Biology 93 (1): 20–29.
Vancouver
1.
Oestreicher U, Samaga D, Ainsbury E, Antunes AC, Baeyens A, Barrios L, et al. RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA). INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2017;93(1):20–9.
IEEE
[1]
U. Oestreicher et al., “RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA),” INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, vol. 93, no. 1, pp. 20–29, 2017.
@article{8507326,
  abstract     = {Purpose: Two quality controlled inter-laboratory exercises were organized within the EU project ‘Realizing the European Network of Biodosimetry (RENEB)’ to further optimize the dicentric chromosome assay (DCA) and to identify needs for training and harmonization activities within the RENEB network.
Materials and methods: The general study design included blood shipment, sample processing, analysis of chromosome aberrations and radiation dose assessment. After manual scoring of dicentric chromosomes in different cell numbers dose estimations and corresponding 95% confidence intervals were submitted by the participants.
Results: The shipment of blood samples to the partners in the European Community (EU) were performed successfully. Outside the EU unacceptable delays occurred. The results of the dose estimation demonstrate a very successful classification of the blood samples in medically relevant groups. In comparison to the 1st exercise the 2nd intercomparison showed an improvement in the accuracy of dose estimations especially for the high dose point.
Conclusions: In case of a large-scale radiological incident, the pooling of ressources by networks can enhance the rapid classification of individuals in medically relevant treatment groups based on the DCA. The performance of the RENEB network as a whole has clearly benefited from harmonization processes and specific training activities for the network partners.},
  author       = {Oestreicher, Ursula and Samaga, Daniel and Ainsbury, Elizabeth and Antunes, Ana Catarina and Baeyens, Ans and Barrios, Leonardo and Beinke, Christina and Beukes, Philip and Blakely, William F. and Cucu, Alexandra and De Amicis, Andrea and Depuydt, Julie and De Sanctis, Stefania and Di Giorgio, Marina and Dobos, Katalin and Dominguez, Inmaculada and Duy, Pham Ngoc and Espinoza, Marco E. and Flegal, Farrah N. and Figel, Markus and Garcia, Omar and Monteiro Gil, Octávia and Gregoire, Eric and Guerrero-Carbajal, C. and Güçlü, İnci and Hadjidekova, Valeria and Hande, Prakash and Kulka, Ulrike and Lemon, Jennifer and Lindholm, Carita and Lista, Florigio and Lumniczky, Katalin and Martinez-Lopez, Wilner and Maznyk, Nataliya and Meschini, Roberta and M’kacher, Radia and Montoro, Alegria and Moquet, Jayne and Moreno, Mercedes and Noditi, Mihaela and Pajic, Jelena and Radl, Analía and Ricoul, Michelle and Romm, Horst and Roy, Laurence and Sabatier, Laure and Sebastià, Natividad and Slabbert, Jacobus and Sommer, Sylwester and Stuck Oliveira, Monica and Subramanian, Uma and Suto, Yumiko and Que, Tran and Testa, Antonella and Terzoudi, Georgia and Vral, Anne and Wilkins, Ruth and Yanti, LusiYanti and Zafiropoulos, Demetre and Wojcik, Andrzej},
  issn         = {0955-3002},
  journal      = {INTERNATIONAL JOURNAL OF RADIATION BIOLOGY},
  keywords     = {Biological dosimetry,dicentric chromosomes,intercomparison,network,RENEB,RADIATION BIODOSIMETRY,BIOLOGICAL DOSIMETRY,EUROPEAN NETWORK,TRIAGE,CASUALTIES,MODE},
  language     = {eng},
  number       = {1},
  pages        = {20--29},
  title        = {RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA)},
  url          = {http://dx.doi.org/10.1080/09553002.2016.1233370},
  volume       = {93},
  year         = {2017},
}

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