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The RENEB operational basis : complement of established biodosimetric assays

Author
Organization
Project
RENEB (Realizing the European Network in Biodosimetry)
Abstract
Purpose: To set up an operational basis of the Realizing the European Network of Biodosimetry (RENEB) network within which the application of seven established biodosimetric tools (the dicentric assay, the FISH assay, the micronucleus assay, the PCC assay, the gamma-H2AX assay, electron paramagnetic resonance and optically stimulated luminescence) will be compared and standardized among the participating laboratories. Methodology: Two intercomparisons were organized where blood samples and smartphone components were irradiated, coded and sent out to participating laboratories for dosimetric analysis. Moreover, an accident exercise was organized during which each RENEB partner had the chance to practice the procedure of activating the network and to handle large amounts of dosimetric results. Results: All activities were carried out as planned. Overall, the precision of dose estimates improved between intercomparisons 1 and 2, clearly showing the value of running such regular activities. Conclusions: The RENEB network is fully operational and ready to act in case of a major radiation emergency. Moreover, the high capacity for analyzing radiation-induced damage in cells and personal electronic devices makes the network suitable for large-scale analyses of low doses effects, where high numbers of samples must be scored in order to detect weak effects.
Keywords
Biological dosimetry, dosimetry network, intercomparison, radiation emergency, DAMAGE, EMERGENCY, DOSIMETRY, NETWORK

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Citation

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Chicago
Wojcik, Andrzej, Ursula Oestreicher, Lleonard Barrios, Anne Vral, Georgia Terzoudi, Elizabeth Ainsbury, Kai Rothkamm, Francois Trompier, and Ulrike Kulka. 2017. “The RENEB Operational Basis : Complement of Established Biodosimetric Assays.” International Journal of Radiation Biology 93 (1): 15–19.
APA
Wojcik, A., Oestreicher, U., Barrios, L., Vral, A., Terzoudi, G., Ainsbury, E., Rothkamm, K., et al. (2017). The RENEB operational basis : complement of established biodosimetric assays. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 93(1), 15–19.
Vancouver
1.
Wojcik A, Oestreicher U, Barrios L, Vral A, Terzoudi G, Ainsbury E, et al. The RENEB operational basis : complement of established biodosimetric assays. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2017;93(1):15–9.
MLA
Wojcik, Andrzej, Ursula Oestreicher, Lleonard Barrios, et al. “The RENEB Operational Basis : Complement of Established Biodosimetric Assays.” INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 93.1 (2017): 15–19. Print.
@article{8507313,
  abstract     = {Purpose: To set up an operational basis of the Realizing the European Network of Biodosimetry (RENEB) network within which the application of seven established biodosimetric tools (the dicentric assay, the FISH assay, the micronucleus assay, the PCC assay, the gamma-H2AX assay, electron paramagnetic resonance and optically stimulated luminescence) will be compared and standardized among the participating laboratories.
Methodology: Two intercomparisons were organized where blood samples and smartphone components were irradiated, coded and sent out to participating laboratories for dosimetric analysis. Moreover, an accident exercise was organized during which each RENEB partner had the chance to practice the procedure of activating the network and to handle large amounts of dosimetric results.
Results: All activities were carried out as planned. Overall, the precision of dose estimates improved between intercomparisons 1 and 2, clearly showing the value of running such regular activities.
Conclusions: The RENEB network is fully operational and ready to act in case of a major radiation emergency. Moreover, the high capacity for analyzing radiation-induced damage in cells and personal electronic devices makes the network suitable for large-scale analyses of low doses effects, where high numbers of samples must be scored in order to detect weak effects.},
  author       = {Wojcik, Andrzej and Oestreicher, Ursula and Barrios, Lleonard and Vral, Anne and Terzoudi, Georgia and Ainsbury, Elizabeth and Rothkamm, Kai and Trompier, Francois and Kulka, Ulrike},
  issn         = {0955-3002},
  journal      = {INTERNATIONAL JOURNAL OF RADIATION BIOLOGY},
  language     = {eng},
  number       = {1},
  pages        = {15--19},
  title        = {The RENEB operational basis : complement of established biodosimetric assays},
  url          = {http://dx.doi.org/10.1080/09553002.2016.1235296},
  volume       = {93},
  year         = {2017},
}

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