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Indirect solid freeform fabrication of an initiator-free photocrosslinkable hydrogel precursor for the creation of porous scaffolds

(2016) MACROMOLECULAR BIOSCIENCE. 16(12). p.1883-1894
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Abstract
the present work, a photopolymerized urethane-based poly(ethylene glycol) hydrogel is applied as a porous scaffold material using indirect solid freeform fabrication (SFF). This approach combines the benefits of SFF with a large freedom in material selection and applicable concentration ranges. A sacrificial 3D poly(epsilon-caprolactone) structure is generated using fused deposition modeling and used as template to produce hydrogel scaffolds. By changing the template plotting parameters, the scaffold channel sizes vary from 280 to 360 m, and the strut diameters from 340 to 400 m. This enables the production of scaffolds with tunable mechanical properties, characterized by an average hardness ranging from 9 to 43 N and from 1 to 6 N for dry and hydrated scaffolds, respectively. Experiments using mouse calvaria preosteoblasts indicate that a gelatin methacrylamide coating of the scaffolds results in an increased cell adhesion and proliferation with improved cell morphology.
Keywords
biocompatibility, hydrogels, photopolymerization, solid freeform fabrication, tissue engineering, CALCIUM-PHOSPHATE SCAFFOLDS, RAPID PROTOTYPING TECHNIQUE, MARROW STROMAL CELLS, POLYURETHANE HYDROGELS, HYDROXYAPATITE SCAFFOLDS, INTERNAL ARCHITECTURE, MECHANICAL-PROPERTIES, GELATIN HYDROGELS, TISSUE, BONE

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Chicago
Houben, Annemie, Nele Pien, Xi Lu, Francesca Bisi, Jasper Van Hoorick, Matthieu Boone, Patrice Roose, et al. 2016. “Indirect Solid Freeform Fabrication of an Initiator-free Photocrosslinkable Hydrogel Precursor for the Creation of Porous Scaffolds.” Macromolecular Bioscience 16 (12): 1883–1894.
APA
Houben, A., Pien, N., Lu, X., Bisi, F., Van Hoorick, J., Boone, M., Roose, P., et al. (2016). Indirect solid freeform fabrication of an initiator-free photocrosslinkable hydrogel precursor for the creation of porous scaffolds. MACROMOLECULAR BIOSCIENCE, 16(12), 1883–1894.
Vancouver
1.
Houben A, Pien N, Lu X, Bisi F, Van Hoorick J, Boone M, et al. Indirect solid freeform fabrication of an initiator-free photocrosslinkable hydrogel precursor for the creation of porous scaffolds. MACROMOLECULAR BIOSCIENCE. 2016;16(12):1883–94.
MLA
Houben, Annemie, Nele Pien, Xi Lu, et al. “Indirect Solid Freeform Fabrication of an Initiator-free Photocrosslinkable Hydrogel Precursor for the Creation of Porous Scaffolds.” MACROMOLECULAR BIOSCIENCE 16.12 (2016): 1883–1894. Print.
@article{8507236,
  abstract     = {the present work, a photopolymerized urethane-based poly(ethylene glycol) hydrogel is applied as a porous scaffold material using indirect solid freeform fabrication (SFF). This approach combines the benefits of SFF with a large freedom in material selection and applicable concentration ranges. A sacrificial 3D poly(epsilon-caprolactone) structure is generated using fused deposition modeling and used as template to produce hydrogel scaffolds. By changing the template plotting parameters, the scaffold channel sizes vary from 280 to 360 m, and the strut diameters from 340 to 400 m. This enables the production of scaffolds with tunable mechanical properties, characterized by an average hardness ranging from 9 to 43 N and from 1 to 6 N for dry and hydrated scaffolds, respectively. Experiments using mouse calvaria preosteoblasts indicate that a gelatin methacrylamide coating of the scaffolds results in an increased cell adhesion and proliferation with improved cell morphology.},
  author       = {Houben, Annemie and Pien, Nele and Lu, Xi and Bisi, Francesca and Van Hoorick, Jasper and Boone, Matthieu and Roose, Patrice and Van den Bergen, Hugues and Bontinck, Dirk and Bowden, Tim and Dubruel, Peter and Van Vlierberghe, Sandra},
  issn         = {1616-5187},
  journal      = {MACROMOLECULAR BIOSCIENCE},
  keyword      = {biocompatibility,hydrogels,photopolymerization,solid freeform fabrication,tissue engineering,CALCIUM-PHOSPHATE SCAFFOLDS,RAPID PROTOTYPING TECHNIQUE,MARROW STROMAL CELLS,POLYURETHANE HYDROGELS,HYDROXYAPATITE SCAFFOLDS,INTERNAL ARCHITECTURE,MECHANICAL-PROPERTIES,GELATIN HYDROGELS,TISSUE,BONE},
  language     = {eng},
  number       = {12},
  pages        = {1883--1894},
  title        = {Indirect solid freeform fabrication of an initiator-free photocrosslinkable hydrogel precursor for the creation of porous scaffolds},
  url          = {http://dx.doi.org/10.1002/mabi.201600289},
  volume       = {16},
  year         = {2016},
}

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