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Indirect solid freeform fabrication of an initiator-free photocrosslinkable hydrogel precursor for the creation of porous scaffolds

Annemie Houben, Nele Pien UGent, Xi Lu, Francesca Bisi, Jasper Van Hoorick UGent, Matthieu Boone UGent, Patrice Roose, Hugues Van den Bergen, Dirk Bontinck, Tim Bowden, et al. (2016) MACROMOLECULAR BIOSCIENCE. 16(12). p.1883-1894
abstract
the present work, a photopolymerized urethane-based poly(ethylene glycol) hydrogel is applied as a porous scaffold material using indirect solid freeform fabrication (SFF). This approach combines the benefits of SFF with a large freedom in material selection and applicable concentration ranges. A sacrificial 3D poly(epsilon-caprolactone) structure is generated using fused deposition modeling and used as template to produce hydrogel scaffolds. By changing the template plotting parameters, the scaffold channel sizes vary from 280 to 360 m, and the strut diameters from 340 to 400 m. This enables the production of scaffolds with tunable mechanical properties, characterized by an average hardness ranging from 9 to 43 N and from 1 to 6 N for dry and hydrated scaffolds, respectively. Experiments using mouse calvaria preosteoblasts indicate that a gelatin methacrylamide coating of the scaffolds results in an increased cell adhesion and proliferation with improved cell morphology.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
biocompatibility, hydrogels, photopolymerization, solid freeform fabrication, tissue engineering, CALCIUM-PHOSPHATE SCAFFOLDS, RAPID PROTOTYPING TECHNIQUE, MARROW STROMAL CELLS, POLYURETHANE HYDROGELS, HYDROXYAPATITE SCAFFOLDS, INTERNAL ARCHITECTURE, MECHANICAL-PROPERTIES, GELATIN HYDROGELS, TISSUE, BONE
journal title
MACROMOLECULAR BIOSCIENCE
Macromol. Biosci.
volume
16
issue
12
pages
1883 - 1894
Web of Science type
Article
Web of Science id
000390804200013
JCR category
POLYMER SCIENCE
JCR impact factor
3.238 (2016)
JCR rank
17/86 (2016)
JCR quartile
1 (2016)
ISSN
1616-5187
DOI
10.1002/mabi.201600289
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8507236
handle
http://hdl.handle.net/1854/LU-8507236
date created
2017-02-03 07:44:59
date last changed
2017-11-08 13:44:00
@article{8507236,
  abstract     = {the present work, a photopolymerized urethane-based poly(ethylene glycol) hydrogel is applied as a porous scaffold material using indirect solid freeform fabrication (SFF). This approach combines the benefits of SFF with a large freedom in material selection and applicable concentration ranges. A sacrificial 3D poly(epsilon-caprolactone) structure is generated using fused deposition modeling and used as template to produce hydrogel scaffolds. By changing the template plotting parameters, the scaffold channel sizes vary from 280 to 360 m, and the strut diameters from 340 to 400 m. This enables the production of scaffolds with tunable mechanical properties, characterized by an average hardness ranging from 9 to 43 N and from 1 to 6 N for dry and hydrated scaffolds, respectively. Experiments using mouse calvaria preosteoblasts indicate that a gelatin methacrylamide coating of the scaffolds results in an increased cell adhesion and proliferation with improved cell morphology.},
  author       = {Houben, Annemie and Pien, Nele and Lu, Xi and Bisi, Francesca and Van Hoorick, Jasper and Boone, Matthieu and Roose, Patrice and Van den Bergen, Hugues and Bontinck, Dirk and Bowden, Tim and Dubruel, Peter and Van Vlierberghe, Sandra},
  issn         = {1616-5187},
  journal      = {MACROMOLECULAR BIOSCIENCE},
  keyword      = {biocompatibility,hydrogels,photopolymerization,solid freeform fabrication,tissue engineering,CALCIUM-PHOSPHATE SCAFFOLDS,RAPID PROTOTYPING TECHNIQUE,MARROW STROMAL CELLS,POLYURETHANE HYDROGELS,HYDROXYAPATITE SCAFFOLDS,INTERNAL ARCHITECTURE,MECHANICAL-PROPERTIES,GELATIN HYDROGELS,TISSUE,BONE},
  language     = {eng},
  number       = {12},
  pages        = {1883--1894},
  title        = {Indirect solid freeform fabrication of an initiator-free photocrosslinkable hydrogel precursor for the creation of porous scaffolds},
  url          = {http://dx.doi.org/10.1002/mabi.201600289},
  volume       = {16},
  year         = {2016},
}

Chicago
Houben, Annemie, Nele Pien, Xi Lu, Francesca Bisi, Jasper Van Hoorick, Matthieu Boone, Patrice Roose, et al. 2016. “Indirect Solid Freeform Fabrication of an Initiator-free Photocrosslinkable Hydrogel Precursor for the Creation of Porous Scaffolds.” Macromolecular Bioscience 16 (12): 1883–1894.
APA
Houben, A., Pien, N., Lu, X., Bisi, F., Van Hoorick, J., Boone, M., Roose, P., et al. (2016). Indirect solid freeform fabrication of an initiator-free photocrosslinkable hydrogel precursor for the creation of porous scaffolds. MACROMOLECULAR BIOSCIENCE, 16(12), 1883–1894.
Vancouver
1.
Houben A, Pien N, Lu X, Bisi F, Van Hoorick J, Boone M, et al. Indirect solid freeform fabrication of an initiator-free photocrosslinkable hydrogel precursor for the creation of porous scaffolds. MACROMOLECULAR BIOSCIENCE. 2016;16(12):1883–94.
MLA
Houben, Annemie, Nele Pien, Xi Lu, et al. “Indirect Solid Freeform Fabrication of an Initiator-free Photocrosslinkable Hydrogel Precursor for the Creation of Porous Scaffolds.” MACROMOLECULAR BIOSCIENCE 16.12 (2016): 1883–1894. Print.