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A preclinical study of an implanted device in the pulmonary veins, intended for the treatment of atrial fibrillation in an ovine model

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Abstract
Background: Atrial fibrillation is the most frequent arrhythmia in adults of which the interventional cure is hampered by high recurrence rates. Recurrence after ablation is due to an incomplete isolation of the pulmonary veins. A new ablation technique was performed, in the antra of ovine pulmonary veins, by device implantation, which was heated through a wireless heat-generating system. Methods and Results: Implants were placed transatrially in the pulmonary veins of sheep. Using a wireless heating system, the energy was afterward transferred through wires to the implanted device according to a defined protocol. The position of the implant and the applied lesions were macroscopically evaluated. Samples of the ablated tissue of the atrio-pulmonary vein junction were histologically and immunohistochemically examined. Conclusions: Six ablation procedures in four sheep were successfully performed without adverse cardiac reactions. Implantation of the device and the wireless heat generation was feasible. Sufficient heat was produced at the level of the antra of the pulmonary veins to create ablation lesions, which were histologically and immunohistochemically confirmed.
Keywords
electromagnetic heating, sheep, implant, wireless, ablation, RADIOFREQUENCY ABLATION, INITIATION, CATHETER, PROTEINS

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Chicago
Vandecasteele, Tim, Tim Boussy, Matthew Philpott, Eli Clement, Stijn Schauvliege, Wim Van Den Broeck, Gunther van Loon, Pieter Cornillie, and Glenn Van Langenhove. 2016. “A Preclinical Study of an Implanted Device in the Pulmonary Veins, Intended for the Treatment of Atrial Fibrillation in an Ovine Model.” Pace-pacing and Clinical Electrophysiology 39 (8): 822–829.
APA
Vandecasteele, Tim, Boussy, T., Philpott, M., Clement, E., Schauvliege, S., Van Den Broeck, W., van Loon, G., et al. (2016). A preclinical study of an implanted device in the pulmonary veins, intended for the treatment of atrial fibrillation in an ovine model. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 39(8), 822–829.
Vancouver
1.
Vandecasteele T, Boussy T, Philpott M, Clement E, Schauvliege S, Van Den Broeck W, et al. A preclinical study of an implanted device in the pulmonary veins, intended for the treatment of atrial fibrillation in an ovine model. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY. 2016;39(8):822–9.
MLA
Vandecasteele, Tim, Tim Boussy, Matthew Philpott, et al. “A Preclinical Study of an Implanted Device in the Pulmonary Veins, Intended for the Treatment of Atrial Fibrillation in an Ovine Model.” PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY 39.8 (2016): 822–829. Print.
@article{8507235,
  abstract     = {Background: Atrial fibrillation is the most frequent arrhythmia in adults of which the interventional cure is hampered by high recurrence rates. Recurrence after ablation is due to an incomplete isolation of the pulmonary veins. A new ablation technique was performed, in the antra of ovine pulmonary veins, by device implantation, which was heated through a wireless heat-generating system. 
Methods and Results: Implants were placed transatrially in the pulmonary veins of sheep. Using a wireless heating system, the energy was afterward transferred through wires to the implanted device according to a defined protocol. The position of the implant and the applied lesions were macroscopically evaluated. Samples of the ablated tissue of the atrio-pulmonary vein junction were histologically and immunohistochemically examined. 
Conclusions: Six ablation procedures in four sheep were successfully performed without adverse cardiac reactions. Implantation of the device and the wireless heat generation was feasible. Sufficient heat was produced at the level of the antra of the pulmonary veins to create ablation lesions, which were histologically and immunohistochemically confirmed.},
  author       = {Vandecasteele, Tim and Boussy, Tim and Philpott, Matthew and Clement, Eli and Schauvliege, Stijn and Van Den Broeck, Wim and van Loon, Gunther and Cornillie, Pieter and Van Langenhove, Glenn},
  issn         = {0147-8389},
  journal      = {PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY},
  keyword      = {electromagnetic heating,sheep,implant,wireless,ablation,RADIOFREQUENCY ABLATION,INITIATION,CATHETER,PROTEINS},
  language     = {eng},
  number       = {8},
  pages        = {822--829},
  title        = {A preclinical study of an implanted device in the pulmonary veins, intended for the treatment of atrial fibrillation in an ovine model},
  url          = {http://dx.doi.org/10.1111/pace.12899},
  volume       = {39},
  year         = {2016},
}

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