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The distribution of lectins across the phylum Nematoda : a genome-wide search

Lander Bauters (UGent) , Diana Naalden (UGent) and Godelieve Gheysen (UGent)
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Abstract
Nematodes are a very diverse phylum that has adapted to nearly every ecosystem. They have developed specialized lifestyles, dividing the phylum into free-living, animal, and plant parasitic species. Their sheer abundance in numbers and presence in nearly every ecosystem make them the most prevalent animals on earth. In this research nematode-specific profiles were designed to retrieve predicted lectin-like domains from the sequence data of nematode genomes and transcriptomes. Lectins are carbohydrate-binding proteins that play numerous roles inside and outside the cell depending on their sugar specificity and associated protein domains. The sugar-binding properties of the retrieved lectin-like proteins were predicted in silico. Although most research has focused on C-type lectin-like, galectin-like, and calreticulin-like proteins in nematodes, we show that the lectin-like repertoire in nematodes is far more diverse. We focused on C-type lectins, which are abundantly present in all investigated nematode species, but seem to be far more abundant in free-living species. Although C-type lectin-like proteins are omnipresent in nematodes, we have shown that only a small part possesses the residues that are thought to be essential for carbohydrate binding. Curiously, hevein, a typical plant lectin domain not reported in animals before, was found in some nematode species.
Keywords
nematode, C-type lectin, hevein, bioinformatic analysis, C-TYPE-LECTIN, ER-ASSOCIATED DEGRADATION, CARBOHYDRATE-RECOGNITION DOMAINS, RETICULUM-ASSOCIATED DEGRADATION, SUGAR-BINDING PROPERTIES, MANNOSIDASE-LIKE PROTEIN, ROOT-LESION NEMATODE, CAENORHABDITIS-ELEGANS, ENDOPLASMIC-RETICULUM, PARASITIC NEMATODE

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Citation

Please use this url to cite or link to this publication:

Chicago
Bauters, Lander, Diana Naalden, and Godelieve Gheysen. 2017. “The Distribution of Lectins Across the Phylum Nematoda : a Genome-wide Search.” International Journal of Molecular Sciences 18 (1).
APA
Bauters, Lander, Naalden, D., & Gheysen, G. (2017). The distribution of lectins across the phylum Nematoda : a genome-wide search. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(1).
Vancouver
1.
Bauters L, Naalden D, Gheysen G. The distribution of lectins across the phylum Nematoda : a genome-wide search. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2017;18(1).
MLA
Bauters, Lander, Diana Naalden, and Godelieve Gheysen. “The Distribution of Lectins Across the Phylum Nematoda : a Genome-wide Search.” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18.1 (2017): n. pag. Print.
@article{8507156,
  abstract     = {Nematodes are a very diverse phylum that has adapted to nearly every ecosystem. They have developed specialized lifestyles, dividing the phylum into free-living, animal, and plant parasitic species. Their sheer abundance in numbers and presence in nearly every ecosystem make them the most prevalent animals on earth. In this research nematode-specific profiles were designed to retrieve predicted lectin-like domains from the sequence data of nematode genomes and transcriptomes. Lectins are carbohydrate-binding proteins that play numerous roles inside and outside the cell depending on their sugar specificity and associated protein domains. The sugar-binding properties of the retrieved lectin-like proteins were predicted in silico. Although most research has focused on C-type lectin-like, galectin-like, and calreticulin-like proteins in nematodes, we show that the lectin-like repertoire in nematodes is far more diverse. We focused on C-type lectins, which are abundantly present in all investigated nematode species, but seem to be far more abundant in free-living species. Although C-type lectin-like proteins are omnipresent in nematodes, we have shown that only a small part possesses the residues that are thought to be essential for carbohydrate binding. Curiously, hevein, a typical plant lectin domain not reported in animals before, was found in some nematode species.},
  articleno    = {91},
  author       = {Bauters, Lander and Naalden, Diana and Gheysen, Godelieve},
  issn         = {1422-0067},
  journal      = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
  keyword      = {nematode,C-type lectin,hevein,bioinformatic analysis,C-TYPE-LECTIN,ER-ASSOCIATED DEGRADATION,CARBOHYDRATE-RECOGNITION DOMAINS,RETICULUM-ASSOCIATED DEGRADATION,SUGAR-BINDING PROPERTIES,MANNOSIDASE-LIKE PROTEIN,ROOT-LESION NEMATODE,CAENORHABDITIS-ELEGANS,ENDOPLASMIC-RETICULUM,PARASITIC NEMATODE},
  language     = {eng},
  number       = {1},
  pages        = {22},
  title        = {The distribution of lectins across the phylum Nematoda : a genome-wide search},
  url          = {http://dx.doi.org/10.3390/ijms18010091},
  volume       = {18},
  year         = {2017},
}

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