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Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation

Author
Organization
Project
RENEB (Realizing the European Network in Biodosimetry)
Abstract
Purpose: In the frame of the QA program of RENEB, an inter-laboratory comparison (ILC) of calibration sources used in biological dosimetry was achieved to investigate the influence of calibration practices and protocols on the results of the dose estimation performance as a first step to harmonization and standardization of dosimetry and irradiation practices in the European biological dosimetry network. Materials and methods: Delivered doses by irradiation facilities used by RENEB partners were determined with EPR/alanine dosimetry system. Dosimeters were irradiated in the same conditions as blood samples. A short survey was also performed to collect the information needed for the data analysis and evaluate the diversity of practices. Results: For most of partners the deviation of delivered dose from the targeted dose remains below 10%. Deviations larger than 10% were observed for five facilities out of 21. Origins of the largest discrepancies were identified. Correction actions were evaluated as satisfactory. The re-evaluation of some ILC results for the fluorescence in situ hybridization (FISH) and premature chromosome condensation (PCC) assays has been performed leading to an improvement of the overall performances. Conclusions: This work has shown the importance of dosimetry in radiobiology studies and the needs of harmonization, standardization in irradiation and dosimetry practices and educational training for biologists using ionizing radiation.
Keywords
Alanine dosimetry, biological dosimetry, calibration, inter-laboratory comparison, quality assurance, ALANINE DOSIMETRY SYSTEM, HIGH-ENERGY PHOTON, ELECTRON-BEAMS, RADIOTHERAPY, PROTOCOL, RADIOBIOLOGY, IRRADIATION, KV

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Citation

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Chicago
Trompier, François, Marion Baumann, Lleonard Barrios, Eric Gregoire, Michael Abend, Elizabeth Ainsbury, Stephen Barnard, et al. 2017. “Investigation of the Influence of Calibration Practices on Cytogenetic Laboratory Performance for Dose Estimation.” International Journal of Radiation Biology 93 (1): 118–126.
APA
Trompier, F., Baumann, M., Barrios, L., Gregoire, E., Abend, M., Ainsbury, E., Barnard, S., et al. (2017). Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 93(1), 118–126.
Vancouver
1.
Trompier F, Baumann M, Barrios L, Gregoire E, Abend M, Ainsbury E, et al. Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2017;93(1):118–26.
MLA
Trompier, François, Marion Baumann, Lleonard Barrios, et al. “Investigation of the Influence of Calibration Practices on Cytogenetic Laboratory Performance for Dose Estimation.” INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 93.1 (2017): 118–126. Print.
@article{8507150,
  abstract     = {Purpose: In the frame of the QA program of RENEB, an inter-laboratory comparison (ILC) of calibration sources used in biological dosimetry was achieved to investigate the influence of calibration practices and protocols on the results of the dose estimation performance as a first step to harmonization and standardization of dosimetry and irradiation practices in the European biological dosimetry network.
Materials and methods: Delivered doses by irradiation facilities used by RENEB partners were determined with EPR/alanine dosimetry system. Dosimeters were irradiated in the same conditions as blood samples. A short survey was also performed to collect the information needed for the data analysis and evaluate the diversity of practices.
Results: For most of partners the deviation of delivered dose from the targeted dose remains below 10\%. Deviations larger than 10\% were observed for five facilities out of 21. Origins of the largest discrepancies were identified. Correction actions were evaluated as satisfactory. The re-evaluation of some ILC results for the fluorescence in situ hybridization (FISH) and premature chromosome condensation (PCC) assays has been performed leading to an improvement of the overall performances.
Conclusions: This work has shown the importance of dosimetry in radiobiology studies and the needs of harmonization, standardization in irradiation and dosimetry practices and educational training for biologists using ionizing radiation.},
  author       = {Trompier, Fran\c{c}ois and Baumann, Marion and Barrios, Lleonard and Gregoire, Eric and Abend, Michael and Ainsbury, Elizabeth and Barnard, Stephen and Barquinero, Joan Francesc and Bautista, Juan Antonio and Brzozowska, Beata and Perez-Calatayud, Jose and De Angelis, Cinzia and Dom{\'i}nguez, Inmaculada and Hadjidekova, Valeria and Kulka, Ulrike and Mateos, Juan Carlos and Meschini, Roberta and Monteiro Gil, Oct{\'a}via and Moquet, Jayne and Oestreicher, Ursula and Montoro Pastor, Alegria and Quintens, Roel and Sebasti{\`a}, Natividad and Sommer, Sylwester and Stoyanov, Orlin and Thierens, Hubert and Terzoudi, Georgia and Villaescusa, Juan Ignacio and Vral, Anne and Wojcik, Andrzej and Zafiropoulos, Demetre and Roy, Laurence},
  issn         = {0955-3002},
  journal      = {INTERNATIONAL JOURNAL OF RADIATION BIOLOGY},
  language     = {eng},
  number       = {1},
  pages        = {118--126},
  title        = {Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation},
  url          = {http://dx.doi.org/10.1080/09553002.2016.1213455},
  volume       = {93},
  year         = {2017},
}

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